A5043111605- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Drug-Induced Adverse Reactions
- Cardiovascular Syncope and Autonomic Disorders
- Epilepsy research and treatment
- Urticaria and Related Conditions
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Fungal Infections and Studies
- Protein Tyrosine Phosphatases
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Cerebral Venous Sinus Thrombosis
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Galectins and Cancer Biology
- Polyomavirus and related diseases
- Dementia and Cognitive Impairment Research
- Autoimmune and Inflammatory Disorders Research
University Hospital in Motol
2020-2024
Charles University
2012-2024
Background The possibility to better predict the severity of disease in a patient newly diagnosed with multiple sclerosis would allow treatment strategy be personalized and lead clinical outcomes. Prognostic biomarkers are highly needed. Objective To assess prognostic value intrathecal IgM synthesis, cerebrospinal fluid serum IL-2, IL-6, IL-10, chitinase 3-like 2 neurofilament heavy chains obtained early after onset disease. Methods 58 patients first manifestation were included. After...
Alemtuzumab as a treatment of highly active multiple sclerosis causes rapid decrease in inflammatory activity due the lysis immune cells. Subsequent cytokine release determines infusion-associated reaction that is frequent adverse event alemtuzumab treatment. Recently, serious cardiovascular and thrombotic reactions following infusion have been described. In our study, dynamics coagulation parameters were analyzed 13 patients treated with alemtuzumab. An immediate, significant increase level...
Abstract Objective Refractory epilepsy may have an underlying autoimmune etiology. Our aim was to assess the prevalence of neural autoantibodies in a multicenter national prospective cohort patients with drug‐resistant undergoing surgery utilizing comprehensive clinical, serologic, and histopathological analyses. Methods We prospectively recruited for refractory focal not caused by brain tumor from centers Czech Republic. Perioperatively, we collected cerebrospinal fluid (CSF) and/or serum...
The hippocampus is implicated in amnestic mild cognitive impairment (aMCI). Furthermore, our group reported a novel method known as human variant Morris Water Maze test (hMWM) that used to measure spatial navigation performance elderly persons. We tested the hypothesis right hippocampal atrophy inversely associated with aMCI. A total of 39 participants were included (n=19 subjects aMCI, and n=20 cognitively normal controls). All study underwent neurological extensive neuropsychological...
Roztroušená skleróza je chronické autoimunitní a neurodegenerativní onemocnění, které postihuje zejména mladé ženy ve věku mezi 20 40 lety.Většina pacientů onemocní v reprodukčním věku.Tento článek poskytuje náhled do terapie pacientek plánujících těhotenství na příkladu dvou přibližuje reálnou klinickou praxi.Klíčová slova: roztroušená skleróza, těhotenství, interferon beta