A5080857276- Spectroscopy Techniques in Biomedical and Chemical Research
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Spectroscopy and Chemometric Analyses
- Genetic Neurodegenerative Diseases
- Adolescent and Pediatric Healthcare
- Bipolar Disorder and Treatment
- Neurological and metabolic disorders
- Genetics and Neurodevelopmental Disorders
- Neurological disorders and treatments
- Genetics, Bioinformatics, and Biomedical Research
- Protein Interaction Studies and Fluorescence Analysis
- Childhood Cancer Survivors' Quality of Life
- Epilepsy research and treatment
- Diet and metabolism studies
- Biomedical and Engineering Education
- Computational Drug Discovery Methods
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Cancer, Stress, Anesthesia, and Immune Response
University Hospital in Motol
2023-2024
Charles University
2024
University of Chemistry and Technology, Prague
2014-2016
Chiroptical spectroscopy is able to detect conformational changes of plasmatic biomolecules during type 1 diabetes mellitus.
Chiroptical spectroscopy is able to discriminate colon cancer patients from healthy controls.
Abstract This study presents an in-depth analysis of mitochondrial enzyme activities in Friedreich's ataxia (FA) patients, focusing on the Electron Transport Chain complexes I, II, and IV, Krebs Cycle Citrate Synthase, Coenzyme Q10 levels. It examines a cohort 34 FA comparing their clinical parameters, including disease duration cardiac markers, with those 17 healthy controls. The findings reveal marked reductions II and, specifically, highlighting impairment FA. Additionally, elevated...
Neuropsychiatric symptoms (NPS) are common in hereditary ataxias as a part of the cerebellar cognitive affective syndrome. In Friedreich ataxia (FRDA), one most ataxias, depressive were previously reported, but little is known about other NPS. We aimed to study presence and severity broad range NPS individuals with FRDA assess relationship between disease severity, cognition, quality life examine concordance reported by patients their informants. Mild Behavioral Impairment Checklist (MBI-C),...