A5073807677- Digestive system and related health
- Pancreatitis Pathology and Treatment
- Celiac Disease Research and Management
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Microbial Metabolites in Food Biotechnology
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Diet and metabolism studies
- Enzyme Production and Characterization
- Microscopic Colitis
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Nutrition and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Multiple and Secondary Primary Cancers
- Nutrition, Genetics, and Disease
- Liver Disease and Transplantation
Charles University
2007-2023
Södertörn University
2023
Comenius University Bratislava
2023
Military University Hospital Prague
2002-2018
Military University
2016-2017
Ministry of Health
2016
GTx (United States)
2016
University Gastroenterology
2016
University Hospital Kralovske Vinohrady
1991-2013
Masaryk University
2009
Background Aminosalicylates are used as standard treatment for maintaining remission in ulcerative colitis. As yet, there is no other existing alternative with proven efficacy. In light of the hypothesis that intestinal environment may contribute to pathophysiology colitis, a trial was conducted test effects probiotic an oral preparation non‐pathogenic E. coli . Methods A total 120 patients inactive colitis were included double‐blind, double‐dummy study comparing mesalazine 500 mg t.d.s....
AbstractA study was made of 28 patients with familial hyperlipoproteinemia grouped according to Fredrickson's classification. Patients type I, IV, or V suffered from attacks epigastric pain an increase in pancreatic enzymes blood some cases, but II III never had these symptoms. The incidence disturbances the secretory capacity exocrine pancreas significantly higher than those III. These findings probably represent another feature clinical manifestation hyperlipoproteinemia.Key-words:...
Objective To determine the effect of Escherichia coli Nissle (Mutaflor, Ardeypharm GmbH, Herdecke, Germany) on intestinal colonization, level endotoxin and liver functions in patients with cirrhosis. Methods Thirty-nine cirrhosis diagnosed by means biopsy clinical examinations were randomly allocated to treatment E. or placebo for 42 days. Standard examination, biochemical hematological examinations, microbiological examination stool performed before after treatment. Results In comparing...
Background The effect of probiotics in symptomatic uncomplicated diverticular disease the colon has not been followed. Design Treatment (T1) with an intestinal antimicrobial (dichlorchinolinol) and absorbent (active coal tablets) was compared same set-up supplemented non-pathogenic Escherichia coli (T2) a prospective open trial. Setting study performed at outpatient department tertiary centre. Participants Fifteen subjects (5 males, 10 females) aged 68–91 years (average 74.8 years) presented...
Fourteen 3-carboxypropionyl-tripeptide-p-nitroanilides of the general formula 3-carboxypropionyl-alanyl-alanyl-Y-p-nitroanilide (Y = glycine, norvaline, S-methylcysteine, valine, norleucine, S-ethylcysteine, methionine, leucine, isoleucine, phenylalanine, tyrosine, S-benzylcysteine, Calpha-phenylglycine, and proline) were synthesized their cleavage by elastase, trypsin, chymotrypsin (Km, kcat kcat/Km) was determined. The significance amino acid residues in position Y evaluated firstly with...
Abstract Probiotics are nonpathogenic microorganisms mostly of human origin which, when administered in adequate amounts, confer a health benefit on the host and enable to prevent or improve some diseases. may be natural temporary constituent resident intestinal microflora, but their concentration is not sufficient for therapeutic purposes. The microbiota, epithelium, mucosal immune system constitute gastrointestinal ecosystem. All three components essential complete functional developmental...
Background: Coeliac disease (CD) or gluten-sensitive enteropathy is a chronic gastrointestinal of children and adults. An experimental model using inbred germfree rats has been developed to study the effects intragastric gliadin application on intestinal mucosa. Methods: AVN strain Wistar (inbred F 87)-germfree were used. Gliadin was applied by probe from birth until day 63 (0.5–5 mg per immunization). Intraepithelial lymphocytes (IEL) separated jejunum, surface marker characterization...
Objectives: The main objective is to compare the accuracy of EUS and CEH for diagnosis pancreatic cancer (PC). secondary evaluate FNA determine what extent findings are affected by endosonographer subjectivity.Methods: A prospective single-centre study was conducted in patients with lesions detected on CT. were examined EUS, FNA. obtained results compared final that based cytology further clinical histopathological from subjects who underwent surgery. second reading images performed...
The expression of cytoplasmic c-erb B2, epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and dipeptidylpeptidase IV (DPP IV) was significantly higher in sporadic cancer the right than left colon. In addition, B2 displayed same difference adjacent (less 2 cm) distant (more 5 cm from tumour margin) mucosa. findings cannot be related to Dukes staging. It is suggested that different ontogenic development (from midgut) hindgut) colon may a possible explanation....