A5067147768- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Dementia and Cognitive Impairment Research
- Cerebral Venous Sinus Thrombosis
- Oropharyngeal Anatomy and Pathologies
- Cerebrovascular and genetic disorders
- COVID-19 and healthcare impacts
- Cardiac Imaging and Diagnostics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Research Studies
- Moyamoya disease diagnosis and treatment
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Blood Coagulation and Thrombosis Mechanisms
- Photoacoustic and Ultrasonic Imaging
University Hospital Ostrava
2014-2025
University of Ostrava
2014-2025
Heidelberg University
2023-2024
University Hospital Heidelberg
2023-2024
Bayer (Germany)
2024
Charles University
2022
University Hospital Plzen
2022
Palacký University Olomouc
2009-2022
Hospital de Egas Moniz
2022
University of Thessaly
2022
Silent infarction in the brain can be detected around 34 per cent of patients after carotid endarterectomy (CEA) and 54 angioplasty stenting (CAS). This study compared risk new infarctions undergoing CEA or CAS.Consecutive with internal artery (ICA) stenosis exceeding 70 were screened for inclusion this prospective study. Patients indications intervention, eligible both methods, allocated randomly to CAS. Neurological examination, cognitive function tests MRI undertaken before 24 h...
RNF213/Mysterin has been identified as a susceptibility gene for moyamoya disease, cerebrovascular disease characterized by occlusive lesions in the circle of Willis. The p.R4810K (rs112735431) variant is founder polymorphism that strongly associated with East Asia. Many non-p.R4810K rare variants RNF213 have white patients, although ethnic mutations not investigated this population. In present study, we screened 19 Slovakian and Czech patients. A total 69 coding exons were directly...
BACKGROUND:The aim of the study was to investigate role von Willebrand factor (vWF), vWF-cleaving protease, ADAMTS13, composition thrombus, and patient outcome following mechanical cerebral artery thrombectomy in patients with acute ischemic stroke. MATERIAL AND METHODS:A prospective cohort included 131 stroke (<6 hours) or without intravenous thrombolysis. Interventional procedure parameters, hemocoagulation markers, vWF, histological examination extracted thrombi were performed. The...
Introduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed outcomes and safety EVT c-ICA-O. Methods: Retrospective multicenter cohort study an AIS c-ICA-O, within 24-h since last-seen-well. Comparisons were made between best medical (BMT). The primary outcome was 3-months modified Rankin Scale (mRS) ordinal shift. Secondary included 3-month...
<h3>Aims</h3> Optic nerve sheath diameter (ONSD) enlargement is detectable in patients with increased intracranial pressure. The aim was to detect an of the ONSD using optic sonography acute intracerebral haemorrhage (ICH) within 6 h onset symptoms. <h3>Methods</h3> Thirty-one ICH patients, 15 age-matched ischaemic stroke and 16 healthy volunteers were enrolled consecutively this prospective bi-centre observational study. All underwent brain CT, transcranial colour-coded duplex (TCCS) at...
Background and Purpose— Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, large infarct core. Sphenopalatine ganglion (SPG) stimulation enhance collateral flow stabilize the blood-brain barrier offers an alternative, potentially more widely deliverable, therapy. Methods— In a randomized, sham-controlled, double-masked trial at 41 centers in 7 countries,...
Objectives The aim of this retrospective study was to compare intracranial arterial stenosis in patients with stroke using 3 different methods: transcranial color-coded duplex sonography, computed tomographic (CT) angiography, and digital subtraction angiography a common clinical practice. Methods Sixty-seven (47 male 20 female; age range, 23–79 years; mean ± SD, 62.0 9.5 years) were enrolled over 40 months. All underwent examinations the arteries CT angiography. Findings divided into 4...
BACKGROUND:We investigated the properties and effects of 5 mechanical thrombectomy procedures in patients with acute ischemic stroke. The relationships between type procedure, time required, success recanalization, clinical outcome were analyzed. MATERIAL AND METHODS:This prospective comparative analysis included 500 stroke large-vessel occlusion. We compared contact aspiration (ADAPT, n=100), stent retriever first line (SRFL, n=196), Solumbra technique (n=64), plus implantation (n=81), a...
<i>Background:</i> The early recanalization (ER) of an occluded cerebral artery is important for clinical improvement in acute ischemic stroke. aim the study was to assess possible association between prior use antiplatelets (AP) and ER middle (MCA) after intravenous thrombolysis (IVT). <i>Methods:</i> In 146 consecutive stroke patients presenting with MCA treated IVT, incidence symptomatic intracerebral hemorrhage (SICH) were compared according presence or absence AP...
ABSTRACT Acute occlusion of cervical or intracranial arteries is the most common cause ischemic stroke (IS). The aims current study were to compare occurrence acute pathologic findings in using transcranial color‐coded sonography (TCCS) and computed tomographic angiography (CTA) performed within 3 hours IS onset assess correlation between vascular on admission patient's clinical state months after IS. Forty‐five consecutive patients with an included prospective during 18‐month period. All...
Acute ischemic stroke (AIS) due to anterior circulation tandem lesion (TL) remains a technical and clinical challenge for endovascular treatment (EVT). Conflicting results from observational studies missing evidence the randomized trials led us report recent real-world multicenter experience evaluate possible predictors of good outcome after EVT.We analyzed all AIS patients with TL enrolled in prospective national study METRICS (Mechanical Thrombectomy Quality Indicators Study Czech Stroke...
Objective: To identify predictors of good outcome in acute basilar artery occlusion (BAO). Background: Acute ischemic stroke (AIS) caused by BAO is often associated with a severe and persistent neurological deficit high mortality rate. Methods: The set consisted 70 consecutive AIS patients (51 males; mean age 64.5±14.5 years) BAO. role the following factors was assessed: baseline characteristics, risk factors, pre-event antithrombotic treatment, at time estimated to therapy procedure...
Background and aim In-stent restenosis (ISR) belongs to an infrequent but potentially serious complication after carotid angioplasty stenting in patients with severe stenosis. Some of these might be contraindicated repeat percutaneous transluminal or without (rePTA/S). The purpose the study is compare safety effectiveness endarterectomy stent removal (CEASR) rePTA/S ISR. Methods Consecutive ISR (≥80%) were randomly allocated CEASR group. incidence intervention, stroke, transient ischaemic...
Jana Janoutová, Ondřej Machaczka, Martina Kovalová, Anna Zatloukalová, Petr Ambroz, Veronika Koutná, Eva Mrázková, Michal Bar, Martin Roubec, Petra Bártová, Richard Novobilský, Sabela, Pavlína Kušnierová, David Stejskal, Lucie Faldynová, Sylwia Walczysková, Vališ, Lukáš Školoudík, Šolínová, Vladimír Janout
<h3>BACKGROUND AND PURPOSE:</h3> Recanalization is the important outcome measure for acute stroke therapy. Several methods of recanalization assessment are used in clinical practice, but few studies have addressed their reliability. We, therefore, sought to assess interobserver reliability diagnosis intracranial artery following intervention by using TIMI criteria. <h3>MATERIALS METHODS:</h3> The digital angiography scans all patients with ischemic during 2009 undergoing DSA and endovascular...
Background Despite all the gains that have been achieved with endovascular mechanical thrombectomy revascularization and intravenous thrombolysis logistics since 2015, there is still a subgroup of patients salvageable brain tissue for whom persistent emergent large vessel occlusion portends catastrophic outcome. Objective To test safety efficacy microsurgical intervention in acute ischemic stroke symptomatic middle cerebral artery after failure thrombectomy. Methods A prospective two-center...
To compare safety and utility of intraarterial revascularization with use stents to no in patients who either failed respond intravenous thrombolysis (IVT) or have contraindications IVT.The case-control study was approved by local ethics committees; all signed informed consent. One hundred thirty-one (74 men; mean age, 65.9 years ± 12.3; range, 25-86 years) acute ischemic stroke (AIS) due middle cerebral artery (MCA) occlusion were enrolled; 75 underwent IVT. No further recanalization...
Embolization from atherosclerotic carotid plaques is the most common cause of ischemic stroke; therefore, identification high-risk by sonography important. The aim this study was to investigate agreement between 2 investigators in evaluation sonographic parameters relating plaque stability.The following were assessed: echogenicity, homogeneity, surface, maximum content, and total volume. Serial 2-dimensional (2D) image sequences obtained. Linear motion probe automatically synchronized with...
Sonolysis is a new therapeutic procedure for arterial recanalization. The aim of this study was to confirm the safety and efficacy endovascular sonolysis by using EkoSonic Endovascular System in subjects with acute ischemic stroke.Patients stroke occlusion middle cerebral artery or basilar were enrolled consecutively prospective study. control group (44 MCA 12 BA occlusions) selected from historical controls. started within 8 hours after onset. NIHSS score at hospital admission, 24 hours, 7...
Accurate assessment of carotid stenosis severity is important for proper patient management. The present study aimed to compare the evaluation using four duplex sonography (DUS) measurements, including peak systolic velocity (PSV), PSV ratio in and distal (PSVICA/ICA ratio), end-diastolic (EDV), B-mode, with computed tomography angiography (CTA), evaluate impact plaque morphology on correlation between DUS CTA.Consecutive patients ≥40% examined CTA were included. Plaque was also determined...