Antonio Núñez

ORCID: 0000-0003-1295-1594
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About
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Research Areas
  • Embedded Systems Design Techniques
  • Low-power high-performance VLSI design
  • Advancements in PLL and VCO Technologies
  • Parallel Computing and Optimization Techniques
  • Semiconductor materials and devices
  • Advancements in Semiconductor Devices and Circuit Design
  • Interconnection Networks and Systems
  • Radio Frequency Integrated Circuit Design
  • VLSI and Analog Circuit Testing
  • Advanced Vision and Imaging
  • Advanced Image Processing Techniques
  • VLSI and FPGA Design Techniques
  • Video Coding and Compression Technologies
  • Semiconductor Lasers and Optical Devices
  • Analog and Mixed-Signal Circuit Design
  • Image and Signal Denoising Methods
  • 3D IC and TSV technologies
  • Silicon Carbide Semiconductor Technologies
  • Auction Theory and Applications
  • GaN-based semiconductor devices and materials
  • Advanced Data Compression Techniques
  • Public-Private Partnership Projects
  • Transportation Planning and Optimization
  • Electromagnetic Compatibility and Noise Suppression
  • Multimedia Communication and Technology

Universidad de Las Palmas de Gran Canaria
2011-2024

Universidad Autónoma de Madrid
1997-2024

Universitat de les Illes Balears
2021-2024

Instituto Federal do Maranhão
2024

College of the Mainland
2024

Universidade Federal de São Carlos
2024

California State Polytechnic University
2022

University of Oklahoma
2021

Universidad Autónoma Metropolitana
2021

Digital Video (Italy)
2018

The identification of specific protein markers for colorectal cancer would provide the basis early diagnosis and detection, as well clues understanding molecular mechanisms governing progression. In this report, we describe proteomic analysis samples corresponding to seven patients. We have used highly sensitive two-dimensional differential gel electrophoresis (2-D DIGE) coupled with mass spectrometry (MS) proteins differentially expressed in tumoral neighboring normal mucosa. detected...

10.1002/pmic.200401196 article EN PROTEOMICS 2005-05-27

The COVID-19 outbreak has affected the sports field unprecedentedly. emergency alert deprived athletes of training in a suitable environment, as they are faced with cancellations relevant events their careers. This situation can cause stress levels and other emotional disorders similar to those experienced by during periods injury. Since relationship between psychological factors injuries is well-studied, Global Psychological Model Sports Injury (MGPLD) applied this historical for athletes....

10.3389/fpubh.2020.561198 article EN cc-by Frontiers in Public Health 2021-01-08

Because of its high content in receptors and signaling proteins, the analysis membrane fractions is critical for study neoplastic diseases as colorectal cancer. Here, we have used new saturation labeling 2D-DIGE proteome cancer mucosal tissues. Samples from 6 patients (tumoral normal paired biopsies) were included this study. Twelve analytical gels performed considered quantitative statistical analysis. A spot pattern analysis, by using an unsupervised clustering algorithm, allowed...

10.1021/pr800152u article EN Journal of Proteome Research 2008-08-16

10.1016/j.econlet.2008.07.017 article EN Economics Letters 2008-07-28

System-level simulation and design space exploration (DSE) are key ingredients for the of multiprocessor system-on-chip (MP-SoC) based embedded systems. The efforts in this area, however, typically use ad-hoc software infrastructures to facilitate support system-level DSE experiments. In paper, we present a new, generic MP-SoC infrastructure, called NASA (Non Ad-hoc Search Algorithm). This highly modular framework uses well-defined interfaces easily integrate different tools as well...

10.1109/estmed.2010.5666979 article EN 2010-10-01
Natan M. Bornstein Jeffrey L. Saver Hans‐Christoph Diener Philip B. Gorelick Ashfaq Shuaib and 95 more Yoram Solberg Thomas Devlin Thomas Leung Carlos A. Molina David Školoudík Jan Fiksa Derk Krieger Grethe Andersen J. Berrouschot Carsten Hobohm Dietmar Schneider B. Griewing Matthias Endres Karl-Georg Hausler Hubert Kimmig Peter A. Ringleb Christian Weimar Matthias Schilling Martin Köhrmann Andreas Hetzel Manfred Kaps Raymond Tak Fai Cheung Piotr Sobolewski Walenty Nyke Anna Członkowska Adam Stępień Brola Waldemar Agnieszka Słowik Stelmasiakiem Zbigniewem I Lubiński Pedro Cardona Portela Tomas Segure Joan Martí–Fàbregas Marı́a Pilar Alonso Antonio Núñez Miguel Blanco Miguel Anna Campello Joaquin Arenillas Nash Marshall David Chiu Harish Shownkeen Marilyn Rymer Souvik Sen Martin Roubec Martin Kuliha Ctirad Lakomý David Tyl David Kemlink Ondřej Doležal Petra Reková Veronika Krejčí Anders Christensen Bo Belhage Christian Maschmann C Larsen Frank Pott Hanne Christensen Jakob Marstrand Jens Kjellberg Nielsen Per Meden Svend Prytz Sverre Rosenbaum Jens Sörensen Kaare Meier Kare Schmift Ettrup Kristina Dupont Hougaard Paul Von Wietzel Anett Stoll Hans Schwetlick Hendirk Pradel Alexander Hemprich Andreas Schulz Bernhard Frerich Carsten Hobohm Christopher M. Weise Dominik Michalski Felix Schaller Franziska Schiefke Jens Helmrich Johann Pelz Martin Schnieder Martin Schneider Peter Matzen Rudiger Langos Stephan Müller-Duerwald Sven Lukhaup Ute Bauer Wolfgang Kloppig Erich Hiermann Gregor Mucha Hassan Soda Renate Weinhardt Teresa Mucha Volker Ziegler Alexander Abbushi

Background and Purpose— Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, large infarct core. Sphenopalatine ganglion (SPG) stimulation enhance collateral flow stabilize the blood-brain barrier offers an alternative, potentially more widely deliverable, therapy. Methods— In a randomized, sham-controlled, double-masked trial at 41 centers in 7 countries,...

10.1161/strokeaha.118.024582 article EN Stroke 2019-05-23

A recent study has shown that losartan, an AT-1-receptor antagonist, interacts with thromboxane A2 (TxA2)/prostaglandin H2 (PGH2) receptors in human platelets. The aim of this was to analyze the ability different angiotensin II (Ang II) antagonists inhibit TxA2-dependent platelet activation. Platelets were obtained from healthy volunteers. stimulated TxA2 analogue, U46619 (10−6M). U46619-stimulated activation significantly reduced by both losartan and irbesartan a dose-dependent manner. Only...

10.1097/00005344-200006000-00012 article EN Journal of Cardiovascular Pharmacology 2000-06-01

Aplidin (plitidepsin) is an antitumoral agent that induces apoptosis via Rac1-JNK activation. A proteomic approach using 2D-DIGE technology found 52 cytosolic and 39 membrane proteins differentially expressed in wild-type Aplidin-resistant HeLa cells, of which 27 were identified by MALDI-TOF mass spectrometry database interrogation. number involved pathways to be deregulated. Alterations Rab geranylgeranyltransferase, protein disulfide isomerase (PDI), cystathionine gamma-lyase, ezrin,...

10.1021/pr060430+ article EN Journal of Proteome Research 2007-03-06

Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from are recognized hallmarks of apoptosis. However, there is no complete understanding the molecular underlying these changes. It likely that epigenetic changes methylation modifications involved in dynamics structure also nuclear described. In this report we have shown apoptosis associated with global hypomethylation deacetylation leukemia cells. Most importantly, observed a...

10.1074/jbc.m601136200 article EN cc-by Journal of Biological Chemistry 2006-03-12

A polymerase chain reaction (PCR) assay for the rapid detection and typing of molluscum contagiosum virus (MCV) was developed. The target DNA a 393 base pair (bp) segment, which is present in coding region MCV p43K gene product. Release from skin lesions performed by using simple procedure that provided suitable template amplification, allowed directly clinical material. PCR yielded unique bp product when used as template. This not shown with other viruses bacterial pathogens causing...

10.1002/(sici)1096-9071(199612)50:4<342::aid-jmv10>3.0.co;2-k article EN Journal of Medical Virology 1996-12-01

A recent study has shown that losartan, an AT 1 -receptor antagonist, interacts with thromboxane 2 (TxA )/prostaglandin H (PGH ) receptors in human platelets. The aim of the present was to analyse ability different angiotensin II (Ang II) antagonists inhibit TxA -dependent platelet activation. Platelets were obtained from healthy volunteers and stimulated analogue, U46619 (10 -6 mol/L). U46619-stimulated activation significantly reduced by losartan a dose-dependent manner. Only maximal doses...

10.3317/jraas.2000.022 article EN Journal of the Renin-Angiotensin-Aldosterone System 2000-06-01

Abstract This study assumes that consumer expenditures occur in a stepwise fashion which income is fist allocated to budget categories and then optimum quantities within each category. With this assumption, model was developed estimate the price icome elasticities of demand all items one category—like food—and cross‐price these with others. The approach permits specify changes expenditure levels on from cross‐section information flexibility money. empirically applied Argentine consumption data.

10.2307/1239158 article EN American Journal of Agricultural Economics 1972-08-01

Nowadays, most of the image contents are recorded in high resolution (HR). Nevertheless, there is still a need low (LR) content presentation when recapturing unviable. As becomes commonplace (with HDTV penetration US estimated at 65% for 2010) viewers expectations on quality and become higher higher. Thus, order to meet today¿s consumer LR has be enhanced before being displayed. Content pre-processing/upscaling methods include interpolation Super-Resolution Image Reconstruction (SRIR). SRIR...

10.1109/tce.2011.5955206 article EN IEEE Transactions on Consumer Electronics 2011-05-01

In this article, we present a flexible and extensible system-level MP-SoC design space exploration (DSE) infrastructure, called NASA. This highly modular framework uses well-defined interfaces to easily integrate different simulation tools as well combinations of search strategies in simple plug-and-play fashion. Moreover, NASA deploys so-called dimension-oriented DSE approach, allowing designers configure the appropriate number of, well-tuned possibly different, algorithms simultaneously...

10.1145/2536747.2536749 article EN ACM Transactions on Embedded Computing Systems 2013-11-01

In this paper, the architecture and implementation of a complex fast Fourier transform (CFFT) processor using 0.6 /spl mu/m gallium arsenide (GaAs) technology are presented. This computes 1024-point FFT 16 bit data in less than 8 mu/s, working at frequency beyond 700 MHz, with power consumption 12.5 W. The is based on COordinate Rotation DIgital Computer (CORDIC) algorithm, which avoids use conventional multiplication-and-accumulation (MAC) units, but evaluates trigonometric functions only...

10.1109/92.661241 article EN IEEE Transactions on Very Large Scale Integration (VLSI) Systems 1998-03-01

Oncogenic Ras signaling has been long known to play an important role in tumorigenesis and human cancer. In this report, we have used the sensitive 2-D-DIGE coupled MS for identification of proteins differentially expressed at cell membrane level between oncogenic H-RasV12-transformed wild-type p38α-deficient mouse embryo fibroblasts (MEFs). Following trifluoroethanol solubilization, 76 were found be regulated. After PMF, 63 spots containing 42 different unequivocally identified by MALDI-TOF...

10.1002/pmic.200500350 article EN PROTEOMICS 2006-03-13

New generation electronic system-level design tools are the key to overcome complexity and increasing productivity gap in development of future multiprocessor systems-on-chip. This paper presents a SystemC-based simulation environment, called CASSE, which helps modeling analysis complex SoCs. CASSE combines application modeling, architecture mapping within unified with aim ease speed up these steps. The main contribution this tool is enable fast at very beginning process, helping space...

10.1109/date.2006.243831 article EN 2006-01-01

In vitro studies have suggested that losartan interacts with the thromboxane (TxA2)/ prostaglandin H2 (PGH2) receptor in human platelets, reducing TxA2-dependent platelet activation. The aim of this study was to evaluate effect different angiotensin II type 1 antagonists stroke-prone spontaneously hypertensive rats (SHRSP). level activation assessed by determining P-selectin expression platelets flow cytometry. ex vivo adhesion also analyzed. number expressed SPSHR significantly increased (%...

10.1097/00005344-200104000-00007 article EN Journal of Cardiovascular Pharmacology 2001-04-01
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