A5065848391- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Optical Imaging and Spectroscopy Techniques
- Cerebrospinal fluid and hydrocephalus
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Disease Prevention
- Cerebral Venous Sinus Thrombosis
- Blood Pressure and Hypertension Studies
- Neurosurgical Procedures and Complications
- Intensive Care Unit Cognitive Disorders
- Heart Rate Variability and Autonomic Control
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrest and Resuscitation
- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Organ Donation and Transplantation
- Sepsis Diagnosis and Treatment
- Radiation Dose and Imaging
- Peripheral Artery Disease Management
- Traumatic Brain Injury Research
- Cerebrovascular and genetic disorders
- Vasculitis and related conditions
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015-2024
Universidade de São Paulo
2014-2024
Brigham and Women's Hospital
2023-2024
Circadian (United States)
2023-2024
Hospital Sírio-Libanês
2023
Instituto Butantan
2023
Universidade Nove de Julho
2020-2021
Emory University
2012-2015
Ricardo (United Kingdom)
2015
Federal Police of Brazil
2013
Background: We validated a new noninvasive tool (B4C) to assess intracranial pressure waveform (ICPW) morphology in set of neurocritical patients, correlating the data with ICPW obtained from invasive catheter monitoring. Materials and Methods: Patients undergoing (ICP) monitoring were consecutively evaluated using B4C sensor. Ultrasound-guided manual internal jugular vein (IJV) compression was performed elevate ICP baseline. values, amplitudes, time intervals (P2/P1 ratio time-to-peak...
Abstract Analysis of intracranial pressure waveforms (ICPW) provides information on compliance. We aimed to assess the correlation between noninvasive ICPW (NICPW) and invasively measured (ICP) NICPW prognostic value in this population. In cohort, acute brain-injured (ABI) patients were included within 5 days from admission six Intensive Care Units. Mean ICP (mICP) values P2/P1 ratio derived analyzed correlated with outcome, which was defined as: (a) early death (ED); survivors spontaneous...
Patients with ischemic heart failure (iHF) have a high risk of neurological complications such as cognitive impairment and stroke. We hypothesized that iHF patients higher incidence impaired dynamic cerebral autoregulation (dCA). Adult healthy volunteers were included. Cerebral blood flow velocity (CBFV, transcranial Doppler, middle artery), end-tidal CO2 (capnography), arterial pressure (Finometer) continuously recorded supine for 5 min at rest. Autoregulation index (ARI) was estimated from...
We aimed to assess cerebral autoregulation (CA) and neurovascular coupling (NVC) in stroke patients of differing severity comparing responses healthy controls explore the association between CA NVC with functional outcome. Patients admitted middle artery (MCA) were recruited. Stroke was defined by National Institutes Health Scale (NIHSS) scores: ≤4 mild, 5–15 moderate ≥16 severe. Transcranial Doppler ultrasound Finometer recorded MCA blood flow velocity (CBFv) pressure, respectively, over 5...
The relationship between dynamic cerebral autoregulation (dCA) and functional outcome after acute ischemic stroke (AIS) is unclear. Previous studies are limited by small sample sizes heterogeneity.
: One of the possible mechanisms by which new coronavirus (SARS-Cov2) could induce brain damage is impairment cerebrovascular hemodynamics (CVH) and intracranial compliance (ICC) due to elevation pressure (ICP). The main objective this study was assess presence CVH ICC alterations in patients with COVID-19 evaluate their association short-term clinical outcomes.
Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility. In an international, multi-centre study, we evaluated the influence of multiple analytical methods on reproducibility DCA. Fourteen participating centers analyzed repeated measurements from 75 healthy subjects, consisting five minutes spontaneous fluctuations in blood pressure (BP) and flow velocity (CBFv) signals, based their usual analysis. DCA- were grouped into three broad categories, depending...
Background: Morphological alterations in intracranial pressure (ICP) pulse waveform (ICPW) secondary to hypertension (ICP >20 mmHg) and a reduction compliance (ICC) are well known indicators of neurological severity. The exclusive exploration modifications ICPW after either the loss skull integrity or surgical procedures for resolution is not common approach studied. present study aimed assess morphological among neurocritical care patients with defects decompressive craniectomy (DC) by...
Critical closing pressure (CrCP) and resistance-area product (RAP) have been conceived as compasses to optimize cerebral perfusion (CPP) monitor cerebrovascular resistance, respectively. However, for patients with acute brain injury (ABI), the impact of intracranial (ICP) variability on these variables is poorly understood. The present study evaluates effects a controlled ICP variation CrCP RAP among ABI.Consecutive neurocritical monitoring were included along transcranial Doppler invasive...
Different methods to calculate dynamic cerebral autoregulation (dCA) parameters are available. However, most of these demonstrate poor reproducibility that limit their reliability for clinical use. Inter-centre differences in study protocols, modelling approaches and default parameter settings have all led a lack standardisation comparability between studies. We evaluated dCA by assessing systematic errors surrogate data resulting from different techniques.Fourteen centres analysed 22...
We tested the influence of blood pressure variability on reproducibility dynamic cerebral autoregulation (DCA) estimates. Data were analyzed from 2nd CARNet bootstrap initiative, where mean arterial (MABP), flow velocity (CBFV) and end tidal CO2 measured twice in 75 healthy subjects. DCA was by 14 different centers with a variety analysis methods. Intraclass Correlation (ICC) values increased significantly when subjects low power spectral density MABP (PSD-MABP) removed for all gain, phase...
Cerebral perfusion pressure (CPP) is normally expressed by the difference between mean arterial blood (MAP) and intracranial (ICP) but comparison of separate contributions MAP ICP to human cerebral flow autoregulation has not been reported. In patients with acute brain injury (ABI), internal jugular vein compression (IJVC) was performed for 60 s. Dynamic (dCA) assessed in recordings middle artery velocity (MCAv, transcranial Doppler), invasive measurements ICP. Patients were separated...
We investigated the effect of handgrip (HG) maneuver on time-varying estimates dynamic cerebral autoregulation (CA) using autoregressive moving average technique.Twelve healthy subjects were recruited to perform HG during 3 minutes with 30% maximum contraction force. Cerebral blood flow velocity, end-tidal CO₂ pressure (PETCO₂), and noninvasive arterial (ABP) continuously recorded baseline, recovery. Critical closing (CrCP), resistance area-product (RAP), index (ARI) obtained.PETCO₂ did not...
<b><i>Background:</i></b> Acute ischaemic stroke (AIS) patients often show impaired cerebral autoregulation (CA). We tested the hypothesis that CA impairment and other alterations in haemodynamics are associated with subtype severity. <b><i>Methods:</i></b> AIS (<i>n</i> = 143) were amalgamated from similar studies. Data baseline (&#x3c; 48 h onset) physiological recordings (beat-to-beat blood pressure [BP], flow velocity (CBFV)...
Cognitive impairment and elevated arterial stiffness have been described in patients with hypertension, but their association has not well studied. We evaluated the correlation of different cognitive domains hypertension compared those normotension. 211 (69 normotension 142 hypertension). Patients were age matched distributed according to blood pressure: normotension, stage 1, 2. function was assessed using Mini-Mental State Examination, Montreal Assessment, a battery neuropsychological...
The incidence of neurological complications, including stroke and cognitive dysfunction, is elevated in patients with heart failure (HF) reduced ejection fraction. We hypothesized that the cerebrovascular response to isometric handgrip (iHG) altered HF. Adults HF healthy volunteers were included. Cerebral blood velocity (CBV; transcranial Doppler, middle cerebral artery) arterial pressure (BP; Finometer) continuously recorded supine for 6 min, corresponding 1 min baseline 3 iHG exercise, at...