A5017811378- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Sodium Intake and Health
- Cognitive Functions and Memory
- Cerebrovascular and genetic disorders
- Optical Imaging and Spectroscopy Techniques
- Neural and Behavioral Psychology Studies
- Pituitary Gland Disorders and Treatments
- Cardiovascular Health and Risk Factors
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Healthcare Systems and Public Health
- Catalytic Processes in Materials Science
- Catalysis and Hydrodesulfurization Studies
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Linguistics and Language Studies
- Neurological Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Older Adults Driving Studies
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2020-2024
Instituto Butantan
2023
Universidade Tecnológica Federal do Paraná
2021
Neurology, Inc
2020
Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro
2019
Most evidence of target-organ damage in hypertension (HTN) is related to the kidneys and heart. Cerebrovascular cognitive impairment are less well studied. Therefore, this study analyzed changes function patients with different stages compared nonhypertensive controls.In a cross-sectional study, 221 (71 normotensive 150 hypertensive) were compared. Patients divided into 2 according blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 1 antihypertensive drugs; HTN-2:...
Cognitive impairment and elevated arterial stiffness have been described in patients with hypertension, but their association has not well studied. We evaluated the correlation of different cognitive domains hypertension compared those normotension. 211 (69 normotension 142 hypertension). Patients were age matched distributed according to blood pressure: normotension, stage 1, 2. function was assessed using Mini-Mental State Examination, Montreal Assessment, a battery neuropsychological...
Abstract Cerebral autoregulation (AR) keeps cerebral blood flow constant despite fluctuations in systemic arterial pressure. The final common AR pathway is made up of vasomotor adjustments cerebrovascular resistance mediated by arterioles. Structural and functional changes the arteriolar wall arise with age hypertension. This study evaluated whether impaired hypertensive patients this impairment differs disease control. Three groups were prospectively compared: under treatment systolic...
ABSTRACT. Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural functional changes of the arterial wall. Objective: To evaluate whether stiffness (AS) is related cerebral blood flow its association with cognitive function in patients hypertension. Methods: 211 (69 normotensive 142 hypertensive) were included. Patients divided into 2 stages: HTN stage-1 stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) a battery...
Central nervous system changes associated to systemic arterial hypertension (SAH) are progressive and may cause negative effects on cognitive performance. The objective of this study was investigate the relation between SAH components executive functions (EF), inhibitory control (IC), updating shifting, comparing a group (without SAH) patients with SAH, in two levels severity.The protocol included following tests evaluate EF components: T.O.V.A. Test Backward Digit Span from Wechsler Adults...
The functioning of attention is complex, a primordial function in several cognitive processes and great interest to neuropsychology. Test Variables Attention (T.O.V.A) continuous computerized performance test that evaluates some components such as response time stimulus errors due inattention impulsivity.1) To evaluate the applicability T.O.V.A Brazilian adults; 2) analyze differences between genders, age ranges, levels education; 3) examine association variables other screening tests.The...
<h3>BACKGROUND AND PURPOSE:</h3> Superagers are defined as older adults with episodic memory performance similar or superior to that in middle-aged adults. This study aimed investigate the key differences discriminative networks and their main nodes between superagers cognitively average elderly controls. In addition, we sought explore sensitivity detecting these functional activities across at 3T 7T MR imaging fields. <h3>MATERIALS METHODS:</h3> Fifty-five subjects 80 years of age were...
<title>Abstract</title> Superagers, older adults with memory performance similar to middle-aged individuals, were studied identify key neural networks responsible for their brain function connectivity. Using a previously published resting-state fMRI (rs-fMRI) dataset from 31 participants (14 superagers and 17 controls) examined at 3 7 Tesla (T) scanners, we cross-validated the findings an Elastic Net regression model using Random Forest algorithm. Important nodes identified based on Mean...
Antihypertensives (AHD) can influence cerebral autoregulation (CA) and attenuate hypertrophic concentric remodelling of arterioles. The aim this study was to examine the associations between AHD, CA structural functional properties arteries.
Abstract Background Some older adults with subjective decline (SCD) had a positive amyloid biomarker indicating preclinical stage of Alzheimer’s disease. Objectives To assess the accuracy Delayed Recall Figure Memory Test (DR‐FMT) Brief Cognitive Screening Battery to predict status in SCD adults. Method The sample consisted 45 classified as and 25 cognitively unimpaired (mean age 76.4 73.5, respectively, p = 0.138). They were evaluated BCSB standard neuropsychological battery (which includes...
Arterial hypertrophy and remodeling are adaptive responses present in systemic arterial hypertension that can result silent ischemia neurodegeneration, compromising brain connections cognitive performance (CP). However, CP is affected differently over time, so traditional screening methods may become less sensitive assessing certain domains. The study aimed to evaluate whether cerebrovascular hemodynamic parameters serve as a tool for hypertensive without clinically manifest decline....
<h3>BACKGROUND AND PURPOSE:</h3> Youthful memory performance in older adults may reflect an underlying resilience to the conventional pathways of aging. Subjects having this unusual characteristic have been recently termed "superagers." This study aimed explore significance imaging biomarkers acquired by <sup>1</sup>H-MRS characterize superagers and differentiate them from their normal-aging peers. <h3>MATERIALS METHODS:</h3> Fifty-five patients than 80 years age were screened using a...
Education is considered to provide a cognitive and neurological reserve through neuronal changes or increased efficacy of processing networks.The hypothesis asserts that older individuals with greater experiential resources exhibit better functioning are able tolerate higher levels brain pathology before displaying clinical symptoms.Hypertension linked impairment.We evaluated the impact hypertension on performance in hypertensive patients high level education.In cross-sectional study 163 (61...
B: Hypertension affects the target-organs diversely. Most evidence on target-organ damage in hypertension is related to kidney and heart. The cerebrovascular cognitive impairment are less studied. O: To study function changes patients with different stages compared control pairs their correlation arterial stiffness properties assessed by non-invasive methods cerebral circulation transcranial Doppler. M: In a cross sectional 162 (42 controls 120 hypertensive) were comparatively evaluated....
Subjective cognitive decline (SCD) is defined as a self-perception of progressive impairment, which not detected objectively through neuropsychological tests. The Alzheimer's Disease Cooperative Study developed the Cognitive Function Instrument (CFI) to evaluate individuals with SCD. CFI consists two versions, namely, self-report and partner report.This study aimed translate into Brazilian Portuguese, perform cross-cultural adaptation, validate version.The translation transcultural...
Introdução: Considerando a implantação da Política Nacional de Humanização (PNH) em 2003, tem-se apontado importância revisão do atendimento oferecido serviços saúde. uma forma propor ações humanizadas é buscar aproximação dos profissionais saúde com as necessidades usuário. o presente resumo descreverá ação humanizada realizada um ambulatório especializado atenção ao idoso zona norte São Paulo durante Dia Mundial Depressão. Conforme dados Organização Saúde (OMS), pessoas mais 65 anos idade...
Age is the main risk factor for dementia, and early stages of cognitive decline may be challenging to identify. Medical care other age-related disorders such as arterial hypertension also have significant impact on reducing dementia prevalence. Patients with suboptimal blood pressure (BP) control remain an elevated cardiovascular impairment. One hundred fifty-six patients were screened: mean age 52.1 ± 11.8 years a history 10.3 8.5 compared group normotensive subjects (age 51,4 13.8 years)....
Abstract Background The term “SuperAgers” (SA) was proposed to define older adults with 80 years or more who have a memory equivalent 20‐30 younger. study aimed investigate cortical amyloid deposition and follow‐up in cohort of SA. Method We identified eleven SA seniors from an initial sample 66 sought the because they believed had exceptional memory. Nine were evaluated two time points (enrollment 1 year follow‐up). PET Pittsburgh Compound‐B labeled carbon‐11 ( 11 C‐PIB) acquired on hybrid...