Background The Montreal Cognitive Assessment (MoCA) is a brief cognitive schedule that has been developed for the screening of patients with Mild Impairment (MCI). MCI recognized as high‐risk state Alzheimer's disease. aim present study to examine reliability and validity Brazilian version MoCA test (MoCA‐BR) in sample older individuals at least 4 years education. Methods MoCA‐BR was administered 112 adults who were classified into three diagnostic groups according their (Alzheimer's...

Transcranial magnetic stimulation (TMS) is a noninvasive brain technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks specific therapy, clinical syndrome associated increased risk of dementia. This study aims assess the effects high-frequency repetitive TMS (HF rTMS) on everyday memory elderly MCI. We conducted double-blinded randomized sham-controlled trial using rTMS over left dorsolateral prefrontal cortex (DLPFC). Thirty-four outpatients meeting...

Most evidence of target-organ damage in hypertension (HTN) is related to the kidneys and heart. Cerebrovascular cognitive impairment are less well studied. Therefore, this study analyzed changes function patients with different stages compared nonhypertensive controls.In a cross-sectional study, 221 (71 normotensive 150 hypertensive) were compared. Patients divided into 2 according blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 1 antihypertensive drugs; HTN-2:...

ABSTRACT Background: At least for a subset of patients, the clinical diagnosis mild cognitive impairment (MCI) may represent an intermediate stage between normal aging and dementia. Nevertheless, patterns transition states MCI to dementia are not well established. In this study we address pattern transitions in patients with healthy controls, prior conversion Methods: 139 subjects (78% women, mean age, 68.5 ± 6.1 years; educational level, 11.7 5.4 years) were consecutively assessed memory...

ABSTRACT Background: The Rivermead Behavioural Memory Test (RBMT) assesses everyday memory by means of tasks which mimic daily challenges. objective was to examine the validity Brazilian version RBMT detect cognitive decline. Methods: 195 older adults were diagnosed as normal controls (NC) or with mild impairment (MCI) Alzheimer's disease (AD) a multidisciplinary team, after participants completed clinical and neuropsychological protocols. Results: Cronbach's α high for total sample profile...

The Computer-Administered Neuropsychological Screen for Mild Cognitive Impairment (CANS-MCI) is a computer-based cognitive screening instrument that involves automated administration and scoring immediate analyses of test sessions. objective this study was to translate culturally adapt the Brazilian Portuguese version CANS-MCI (CANS-MCI-BR) evaluate its reliability validity diagnostic MCI dementia due Alzheimer's disease.

Cognitive impairment and elevated arterial stiffness have been described in patients with hypertension, but their association has not well studied. We evaluated the correlation of different cognitive domains hypertension compared those normotension. 211 (69 normotension 142 hypertension). Patients were age matched distributed according to blood pressure: normotension, stage 1, 2. function was assessed using Mini-Mental State Examination, Montreal Assessment, a battery neuropsychological...

Abstract Cerebral autoregulation (AR) keeps cerebral blood flow constant despite fluctuations in systemic arterial pressure. The final common AR pathway is made up of vasomotor adjustments cerebrovascular resistance mediated by arterioles. Structural and functional changes the arteriolar wall arise with age hypertension. This study evaluated whether impaired hypertensive patients this impairment differs disease control. Three groups were prospectively compared: under treatment systolic...

ABSTRACT. Aging, hypertension (HTN), and other cardiovascular risk factors contribute to structural functional changes of the arterial wall. Objective: To evaluate whether stiffness (AS) is related cerebral blood flow its association with cognitive function in patients hypertension. Methods: 211 (69 normotensive 142 hypertensive) were included. Patients divided into 2 stages: HTN stage-1 stage-2. The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA) a battery...

Central nervous system changes associated to systemic arterial hypertension (SAH) are progressive and may cause negative effects on cognitive performance. The objective of this study was investigate the relation between SAH components executive functions (EF), inhibitory control (IC), updating shifting, comparing a group (without SAH) patients with SAH, in two levels severity.The protocol included following tests evaluate EF components: T.O.V.A. Test Backward Digit Span from Wechsler Adults...

The functioning of attention is complex, a primordial function in several cognitive processes and great interest to neuropsychology. Test Variables Attention (T.O.V.A) continuous computerized performance test that evaluates some components such as response time stimulus errors due inattention impulsivity.1) To evaluate the applicability T.O.V.A Brazilian adults; 2) analyze differences between genders, age ranges, levels education; 3) examine association variables other screening tests.The...

On the title page, authors' affiliations need to be reversed. The first author is affiliated Gerontology Department at School of Arts, Sciences and Humanities (EACH), University São Paulo, remaining authors are Psychogeriatric Unit, Laboratory Neuroscience (LIM 27), Institute Psychiatry, Faculty Medicine, Paulo.

Antihypertensives (AHD) can influence cerebral autoregulation (CA) and attenuate hypertrophic concentric remodelling of arterioles. The aim this study was to examine the associations between AHD, CA structural functional properties arteries.

The Rivermead Behavioral Memory Test (RBMT) is a memory test composed by 12 different tasks and yields two main scores (the screening profile scores). It considered an ecological not generally influenced educational attainment. RBMT has good accuracy to diagnose patients with MCI AD identify at higher risk progress AD, its application time-consuming what may hinder wide use in clinical settings. Therefore, the aim of this study assess if sub-tests help differentiate as compared controls that...

The Montreal Cognitive Assessment (MoCA) is a brief cognitive screening tool with high sensibility for patients Mild Impairment (MCI). MCI recognized as high-risk state or prodrome of Alzheimer's disease (AD). aim the present study to examine reliability and validity Brazilian version MoCA in older subjects. Mini-Mental State Examination (MMSE) were conducted on eighty adults divided into three groups (AD, n = 13; MCI, 36; controls, 31), based clinical neuropsychological data. Diagnostic...

Arterial hypertrophy and remodeling are adaptive responses present in systemic arterial hypertension that can result silent ischemia neurodegeneration, compromising brain connections cognitive performance (CP). However, CP is affected differently over time, so traditional screening methods may become less sensitive assessing certain domains. The study aimed to evaluate whether cerebrovascular hemodynamic parameters serve as a tool for hypertensive without clinically manifest decline....

Normal aging is associated with cognitive impairments, often overlooked in medical practice, especially milder forms, significant impact on quality of life. Such decline has not, up to date, specific treatment approach, leaving a gap the therapeutic arsenal both specialist and general practitioner. Repetitive transcranial magnetic stimulation (rTMS) promising noninvasive painless technique. It potential improve cognition elderly activating neural networks, provides an attractive option as...

Education is considered to provide a cognitive and neurological reserve through neuronal changes or increased efficacy of processing networks.The hypothesis asserts that older individuals with greater experiential resources exhibit better functioning are able tolerate higher levels brain pathology before displaying clinical symptoms.Hypertension linked impairment.We evaluated the impact hypertension on performance in hypertensive patients high level education.In cross-sectional study 163 (61...

B: Hypertension affects the target-organs diversely. Most evidence on target-organ damage in hypertension is related to kidney and heart. The cerebrovascular cognitive impairment are less studied. O: To study function changes patients with different stages compared control pairs their correlation arterial stiffness properties assessed by non-invasive methods cerebral circulation transcranial Doppler. M: In a cross sectional 162 (42 controls 120 hypertensive) were comparatively evaluated....

Patients with Mild Cognitive Impairment (MCI) are at increased risk to develop AD. Nevertheless, most of the currently available screening strategies does not show good accuracy identify this condition. The aim present study is validate a computer-based cognitive assessment battery (CANS-MCI) diagnose patients MCI. Sixty nine older adults (AD, n = 13; MCI, 25; controls, 31) were evaluated CANS-MCI. Diagnostic each test for discriminating between these diagnostic groups (MCI or controls) was...

Clinical relevance of memory complaints is still unclear. Recent data suggested only highly educated complainers have higher risk AD (van Oijen et al., 2007). The objective was to compare the relation between spontaneous and induced cognitive performance at baseline 24-month follow up. A total 119 older adults attended a health lecture (which did not deal with issues) filled out questionnaire, which included an open question about concerns (spontaneous complaint if mentioned) problem...