A5024118447- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Glycogen Storage Diseases and Myoclonus
- Acute Ischemic Stroke Management
- Optical Imaging and Spectroscopy Techniques
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Autoimmune Neurological Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- S100 Proteins and Annexins
- Neuroscience and Neural Engineering
- Cardiac Arrest and Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Non-Invasive Vital Sign Monitoring
- Genetics and Neurodevelopmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Lysosomal Storage Disorders Research
- Neurological and metabolic disorders
- Traumatic Brain Injury Research
- Neonatal and fetal brain pathology
- Thermal Regulation in Medicine
- Transplantation: Methods and Outcomes
University Medical Center Groningen
2016-2025
University of Groningen
2015-2024
Cardiff University
2018
Mental Health Research UK
2018
Radboud University Nijmegen
2011
Radboud University Medical Center
2011
Vrije Universiteit Brussel
2011
Erasmus Hospital
2010
Martini Ziekenhuis
1998-2000
The initiation of hemodialysis is associated with an accelerated decline cognitive function and increased incidence cerebrovascular accidents white matter lesions. Investigators have hypothesized that the repetitive circulatory stress induces ischemic cerebral injury, but mechanism unclear. We studied acute effect conventional on blood flow (CBF), measured by [ 15 O]H 2 O positron emission tomography–computed tomography (PET-CT). During a single session, three PET-CT scans were performed:...
Background and Purpose— Pathophysiological considerations observational studies indicate that elevated body temperature, hypoxia, hypotension, cardiac arrhythmias in the acute phase of ischemic stroke may aggravate brain damage worsen outcome. Methods— Both units were organized with same standard care multidisciplinary approach to nursing rehabilitation. A blinded observer assessed functional outcome at 3 months modified Rankin scale (mRS) Barthel Index (BI). End points (1) poor outcome,...
Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO 2 ) depending on blood flow (CBF), volume and oxygen content. We explored whether NIRS might be a more easy applicable proxy [ 15 O]H O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO CBF. In 12 patients aged ≥ 65 years, PET were performed simultaneously: before (T1), early after start (T2), at the end hemodialysis...
Abstract Background/Objective Current severe traumatic brain injury (TBI) outcome prediction models calculate the chance of unfavourable after 6 months based on parameters measured at admission. We aimed to improve current with addition continuously neuromonitoring data within first 24 h intensive care unit neuromonitoring. Methods Forty-five TBI patients intracranial pressure/cerebral perfusion pressure monitoring from two teaching hospitals covering period May 2012 January 2019 were...
Ramsay Hunt syndrome (progressive myoclonus ataxia) is a descriptive diagnosis characterized by myoclonus, ataxia, and infrequent seizures. Often the etiology cannot be determined. Recently, mutation in GOSR2 gene (c.430G>T, p.Gly144Trp) was reported 6 patients with childhood-onset progressive ataxia myoclonus.We evaluated 5 cortical areflexia.All had same homozygous GOSR2. Here we present their clinical neurophysiological data. Our (aged 7-26 years) all originated from northern Netherlands...
<h3>Objective</h3> To determine the contribution of electrophysiologic testing in diagnosis and anatomical classification myoclonus. <h3>Methods</h3> Participants with a clinical myoclonus were prospectively recruited, each undergoing videotaped examination battery tests. The its subtype was reviewed after 6 months context findings specialist review examination. <h3>Results</h3> Seventy-two patients recruited. Initial included 25 cortical myoclonus, 7 subcortical 2 spinal 15 functional...
Abstract Background Myoclonus is a brief shock‐like, involuntary movement, which can be distinguished in physiologic, essential, epileptic, and symptomatic, according to its etiology. Physiologic myoclonus typically occurs healthy people without disability or progression. Objectives We suggest new nosological entity the physiologic group: “benign idiopathic myoclonus.” Methods present cohort of patients with isolated adolescent‐onset, distal limb at rest during action, absence known cause...
There is uncertainty whether bilateral near infrared spectroscopy (NIRS) can be used for monitoring of patients with acute stroke.The NIRS responsiveness to systemic and stroke-related changes was studied overnight by assessing the effects brief peripheral arterial oxygenation mean pressure alterations in affected versus nonaffected hemisphere 9 stroke.Significantly more drops were registered compared (477 184, P<0.001). In hemispheres, nearly all (n=128; 96%) detected NIRS; hemispheres only...
North Sea Progressive Myoclonus Epilepsy is a rare and severe disorder caused by mutations in the GOSR2 gene. It clinically characterized progressive myoclonus, seizures, early-onset ataxia areflexia. As other myoclonus epilepsies, efficacy of antiepileptic drugs disappointingly limited Epilepsy. The ketogenic diet less restrictive modified Atkins have been proven to be effective drug-resistant epilepsy syndromes, including those with myoclonic seizures. Our aim was evaluate patients...
Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility. In an international, multi-centre study, we evaluated the influence of multiple analytical methods on reproducibility DCA. Fourteen participating centers analyzed repeated measurements from 75 healthy subjects, consisting five minutes spontaneous fluctuations in blood pressure (BP) and flow velocity (CBFv) signals, based their usual analysis. DCA- were grouped into three broad categories, depending...
Niemann-Pick type C (NP-C) is a rare autosomal recessive progressive neurodegenerative disorder caused by mutations in the NP-C 1 or 2 gene. Besides visceral symptoms, presentation adolescent and adult onset variants often with neurological symptoms. The most frequently reported presenting symptoms of adulthood are psychiatric (38 %), cognitive decline (23 %) ataxia (20 %). Myoclonus can be present, but its value early diagnosis evolving clinical phenotype unclear. In this paper we present...
Objective: Cerebrovascular reactivity can provide a continuously updated individualized target for management of cerebral perfusion pressure, termed optimal pressure. The objective this project was to find way improving the pressure methodology by introducing new visualization method. Data Sources: Four severe traumatic brain injury patients with intracranial monitoring. Extraction: were collected and pre-processed using ICM+ software. Synthesis: Sequential curves used create color-coded...