Abstract Analysis of intracranial pressure waveforms (ICPW) provides information on compliance. We aimed to assess the correlation between noninvasive ICPW (NICPW) and invasively measured (ICP) NICPW prognostic value in this population. In cohort, acute brain-injured (ABI) patients were included within 5 days from admission six Intensive Care Units. Mean ICP (mICP) values P2/P1 ratio derived analyzed correlated with outcome, which was defined as: (a) early death (ED); survivors spontaneous...

Critical closing pressure (CrCP) and resistance-area product (RAP) have been conceived as compasses to optimize cerebral perfusion (CPP) monitor cerebrovascular resistance, respectively. However, for patients with acute brain injury (ABI), the impact of intracranial (ICP) variability on these variables is poorly understood. The present study evaluates effects a controlled ICP variation CrCP RAP among ABI.Consecutive neurocritical monitoring were included along transcranial Doppler invasive...

Abstract Neurocritical patients frequently exhibit abnormalities in cerebral hemodynamics (CH) and/or intracranial compliance (ICC), all of which significantly impact their clinical outcomes. Transcranial Doppler (TCD) and the cranial micro-deformation sensor (B4C) are valuable techniques for assessing CH ICC, respectively. However, there is a scarcity data regarding predictive value these determining patient We prospectively included neurocritical undergoing pressure (ICP) monitoring within...

Cerebral perfusion pressure (CPP) is normally expressed by the difference between mean arterial blood (MAP) and intracranial (ICP) but comparison of separate contributions MAP ICP to human cerebral flow autoregulation has not been reported. In patients with acute brain injury (ABI), internal jugular vein compression (IJVC) was performed for 60 s. Dynamic (dCA) assessed in recordings middle artery velocity (MCAv, transcranial Doppler), invasive measurements ICP. Patients were separated...

Abstract Background : Analysis of intracranial pressure waveforms (ICPW) provides information on compliance. We aimed to assess the correlation between noninvasive ICPW (NICPW) and invasively measured (ICP) NICPW prognostic value in this population. Methods In cohort, acute brain-injured patients were included within 5 days from admission six Intensive Care Units. ICP values P2/P1 ratio derived analyzed correlated with outcome, which was defined as: a) early death (ED); survivors spontaneous...

Torque Teno virus (TTV) is a recently discovered with high prevalence worldwide, that has been associated vascular diseases. The aim of this study to investigate the TTV molecular DNA in intracranial aneurysm (IA) artery walls.Samples IA walls were collected after microsurgical clipping from 35 patients (22 ruptured/13 unruptured cases). samples submitted extraction using EasyMag automatized extractor and performed Qiagen Minikit 250. underwent PCR examination primers for β-globin as...

Subarachnoid hemorrhage (SAH) prognosis remains poor. Vasospasm mechanism might be associated with inflammation. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) have been studied as inflammation markers prognostic predictors.We aimed to investigate NLR PLR in admission predictors of angiographic vasospasm functional outcome at 6 months.This cohort study included consecutive aneurysmal SAH patients admitted a tertiary center. Complete blood count was recorded before...

Temporary arterial occlusion (TAO) is a widespread practice in the surgical treatment of intracranial aneurysms. This study aimed to investigate TAO's role during ruptured aneurysm clipping as an independent prognostic factor on short- and long-term outcomes.This prospective cohort included 180 patients with aneurysms indication microsurgical treatment. Patients who died first 12 hours after admission were excluded.TAO was associated intraoperative rupture (IOR) (odds ratio - OR = 10.54; 95%...

This study aims to describe the late clinical outcomes of patients with severe traumatic brain injury (sTBI) and risk factors associated it. Patients were enrolled between April 2012 January 2015 followed until 2022. The inclusion criteria age 16-65 years, Glasgow Coma Scale ≤8 on admission, diagnosis blunt TBI Marshall diffuse type II initial computerized tomography (CT), alive at discharge. Clinical, laboratory, radiological data from admission collected. Outcome Extended (GOSE),...

To evaluate the risk factors for poor outcomes after surgical and endovascular treatment of aneurysmal subarachnoid hemorrhage (aSAH).Patients with ≥ 18-years age aSAH were included, while patients who died within 12 h admission or lost follow-up excluded. All participants underwent standardized clinical radiological assessment on reassessed at discharge 6-months using Glasgow Outcome Scale (GOS).Death was associated female gender, anterior communication artery (ACoA) aneurysm location...

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Abstract Background Aneurysmal subarachnoid hemorrhages (aSAHs) account for 5% of all strokes, an appalling number when it comes to the second most common cause death worldwide. The basis treatment is clinical support and either endovascular or surgical intervention. purpose present study analyze if time from onset thunderclap headache until intervention related degree disability after 6 months. Methods In prospective observational study, data were collected patients (n = 223) admitted...

<title>Abstract</title> Background Neurocritical patients frequently exhibit abnormalities in cerebral hemodynamic (CH) impairment and/or intracranial compliance (ICC), all of which significantly impact their clinical outcomes. Transcranial Doppler (TCD) and the cranial micro-deformation sensor (B4C) are valuable techniques for assessing CH ICC, respectively. However, there is a scarcity data regarding predictive value these determining patient Methods We prospectively included neurocritical...

Abstract Objective The present study aims to assess and compare the prognostic value of these two scales for predicting mortality. Method We reviewed 172 patients with aneurysmal subarachnoid hemorrhage, who were followed-up 6 months. Fisher modified evaluated prediction mortality using logistic regressions. Results scale was associated (odds ratio [OR]: 2; 95% confidence interval [CI]: 1.09–4.05) in multivariate analysis. not analysis (OR: 1.39; CI: 0.9–2.29), nor univariate 1.24; 95%CI:...

Abstract Introduction Pathological processes in the arterial wall that result vessel dilation are cause of intracranial aneurysms (IAs), and risk factors for their formation progression not well established. Ferritin is associated with inflammation angiogenesis; it has protective antioxidative activity, controls cell differentiation. Vitamin B12 related to neurological hematological disorders; can be used as differential diagnosis tool, acts control homocysteinemia, a predictor worse...

Abstract Introduction Intracranial aneurysm (IA) is a major healthcare concern. The use of statin to reduce serum cholesterol has shown evidence cardiovascular risk in various diseases, but the impact on IA not been described. This study aims determine whether use, and levels interfere with outcomes after event. Methods A cohort patients was analyzed. Patients social demographics data were collected. Modified Rankin scale (mRS) score 6 months follow-up endpoint. regarding statins presence or...