A5048245914- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Nanoparticle-Based Drug Delivery
- Schizophrenia research and treatment
- Visual perception and processing mechanisms
- Dementia and Cognitive Impairment Research
- Traditional Chinese Medicine Analysis
- Mitochondrial Function and Pathology
- Animal Virus Infections Studies
- Botulinum Toxin and Related Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Heart Rate Variability and Autonomic Control
- Viral gastroenteritis research and epidemiology
- Transcranial Magnetic Stimulation Studies
- Genetic Associations and Epidemiology
- Tactile and Sensory Interactions
- Cervical and Thoracic Myelopathy
- Electroconvulsive Therapy Studies
Tianjin Medical University
2015-2025
Chinese Academy of Agricultural Sciences
2024
Harbin Veterinary Research Institute
2024
Anhui Medical University
2021-2023
California Institute for Biomedical Research
2023
Guilin University of Electronic Technology
2023
Tianjin Medical University General Hospital
2019-2022
Northwestern Polytechnical University
2022
Nanjing University
2018-2021
SLAC National Accelerator Laboratory
2019
The human brain has been described as a large, sparse, complex network characterized by efficient small-world properties, which assure that the generates and integrates information with high efficiency. Many previous neuroimaging studies have provided consistent evidence of ‘dysfunctional connectivity’ among regions in schizophrenia; however, little is known about whether or not this dysfunctional connectivity causes disruption topological properties functional networks. To end, we...
Abstract Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may disturbed functional connectivity between different brain regions. Furthermore, recent resting‐state magnetic resonance imaging (fMRI) also shown low‐frequency (<0.08 Hz) fluctuations (LFF) of blood oxygenation level‐dependent signals were abnormal in several areas AD patients. However, few investigated LFF By using fMRI, this study sought investigate connectivities throughout entire early...
Using resting-state functional magnetic resonance imaging, we examined the connectivity throughout entire brain in schizophrenia. The abnormalities were identified by comparing correlation coefficients of each pair 116 regions between 15 patients and controls. Then, global distribution abnormal connectivities was examined. Experimental results indicated, general, a decreased schizophrenia during rest, such widely distributed rather than restricted to few specific regions. provide...
Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic factor in the progression AD. The targeted delivery antioxidants mitochondria injured neurons brain promising therapeutic strategy for A safe effective drug system (DDS) which able cross blood-brain barrier (BBB) target neuronal necessary. Recently, bioactive materials-based DDS has been widely investigated...
Early visual deprivation can lead to changes in the brain, which may be explained by either of two hypotheses. The general loss hypothesis has been proposed explain maladjustments, while compensatory plasticity a superior ability use remaining senses. Most previous task-based functional MRI (fMRI) studies have supported hypothesis, but it difficult provide evidence support since blind cannot execute tasks. study resting state fMRI data an opportunity simultaneously detect aspects blind. In...
We used a newly reported regional homogeneity approach to measure the temporal of blood oxygen level-dependent signal for exploring brain activity schizophrenia in resting state. The results showed decreased schizophrenia, which distributed over bilateral frontal, temporal, occipital, cerebellar posterior, right parietal and left limbic lobes, similar findings previous state functional studies. regions that are believed be involved psychopathology pathophysiology schizophrenia. Our indicate...
Early deafness can reshape deprived auditory regions to enable the processing of signals from remaining intact sensory modalities. Cross-modal activation has been observed in during non-auditory tasks early deaf subjects. In hearing subjects, visual working memory evoke cortex, which further contributes behavioural performance. however, whether and how participate remains unclear. We hypothesized that may be involved contribute superior performance this study, 41 subjects (22 females 19...
CRISPR-Cas9 system has been widely used for efficient genome editing. Although the structures of Cas9 protein in complex with single-guided RNA (sgRNA) and target DNA have resolved, molecular details about formation endonuclease R-loop structure remain elusive. Here we examine cleavage activities Streptococcus pyogenes (SpyCas9) its mutants using various sequences study conformational dynamics during binding single-molecule fluorescence energy transfer (smFRET) technique. Our results show...
How pain emerges in the human brain remains an unresolved question. Neuroimaging studies have suggested that several areas subserve perception because their activation correlates with perceived intensity. However, painful stimuli are often intense and highly salient; therefore, using both intensity- saliency-matched control is crucial to isolate pain-selective responses. Here, we used these intensity/saliency-matched non-painful test whether information can be isolated functional magnetic...
Despite widely reported gender differences in both brain structure and function, very few studies have examined the relationship between structural functional genders. Here, different imaging measures including (i.e. gray matter volume (GMV)) regional homogeneity (ReHo) connectivity (FC)) were employed to detect human based on univariate multivariate approaches with a sample of 290 healthy adults (155 females). The analyses revealed that detected (i.e., GMV) (ReHo or FC) measures, mainly...
Studies have indicated that the dorsal attention network (DAN) and ventral (VAN) functionally interact via several fronto-parietal connector hubs. However, anatomical connectivity profiles of these hubs, coupling between functional connectivities them, are still unknown. In present study, we found hubs anatomically bridged DAN VAN based on multimodal magnetic resonance imaging data from Human Connectome Project (HCP) Consortium an independent Chinese cohort. The three had unique patterns...
With the rapid development of machine learning techniques, multivariate pattern analysis (MVPA) is becoming increasingly popular in field neuroimaging data analysis. Several software packages have been developed to facilitate its application studies. As most these are based on command lines, researchers required learn how program, which has greatly limited use MVPA for without programming skills. Moreover, lacking a graphical user interface (GUI) also hinders standardization studies and,...
Structural covariance refers to the concurrent changes in one morphological measure between two brain regions. of cortical measures such as thickness (CT), surface area (SA), and volume (CV) have been applied identify structural differences patients with neuropsychiatric disorders healthy controls. However, precise relationships patterns different remain largely unknown. Here, we optimized preprocessing calculation approaches covariances investigated both global (whole-brain-level) regional...