A5100711316- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immune Response and Inflammation
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Protease and Inhibitor Mechanisms
- 14-3-3 protein interactions
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Powdery Mildew Fungal Diseases
- NF-κB Signaling Pathways
- Spinal Hematomas and Complications
- Nerve injury and regeneration
- Lung Cancer Research Studies
First Hospital of Jiaxing
2025
Jiaxing University
2025
Shanghai Jiao Tong University
2015-2024
Sun Yat-sen University
2024
Shanghai First People's Hospital
2021-2024
Fujian Medical University
2022-2024
Union Hospital
2024
Tongren Hospital
2017-2023
Renji Hospital
2014-2022
Ministry of Health of the Russian Federation
2022
The lncRNA LINC00460 plays crucial roles in several epithelial cancers, although its mechanisms of action differ greatly different cellular contexts. In this study, we aimed to determine the potential clinical applications and elucidate by which affects development progression head neck squamous cell carcinoma (HNSCC).The biological functions were assessed cancer lines. subcellular localization was evaluated nuclear/cytoplasmic fractionation fluorescence situ hybridization. RNA pull-down...
In our previous studies, enhancer of zeste homolog 2 (EZH2) has been proven to be a key oncogenic driver in oral squamous cell carcinoma (OSCC). However, the regulatory mechanisms on EZH2 remain poorly understood OSCC. Here, through multi-transcriptomics, bioinformatics analysis, and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), co-expression network long noncoding RNA RC3H2 (RC3H2), microRNA-101-3p (miR-101-3p), were screened validated as competing endogenous...
Abstract Colorectal cancer (CRC) is one of the most common neoplasms worldwide. However, mechanisms underlying its development are still poorly understood. Thyroid hormone Receptor Interactor 13 (TRIP13) a key mitosis regulator, and recent evidence has shown that it an oncogene. Here, we report TRIP13, which overexpressed in CRC, correlated with CEA (carcino-embryonic antigen), CA19-9 (carbohydrate antigen 19-9) pTNM (pathologic primary tumor, lymph nodes, distant metastasis) classification....
// Yan Li 1,* , Dan Xu Chunyang Bao Yuannv Zhang 1 Di Chen Fangyu Zhao Jie Ding 2 Linhui Liang Qifeng Wang Liu Jinjun Ming Yao Shenglin Huang and Xianghuo He 1,2 State Key Laboratory of Oncogenes Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School Medicine, Shanghai, China Fudan Center Institutes Biomedical Sciences, Department Oncology, Medical College, University, * These authors contributed equally to this work Correspondence: He, email: Huang, Keywords :...
In recent years, the application of functional genetic immuno-oncology screens has showcased striking ability to identify potential regulators engaged in tumor-immune interactions. Although these have yielded substantial data, few studies attempted systematically aggregate and analyze them.In this study, a comprehensive data collection tumor immunity-associated was performed. Large-scale genomic sets were exploited conduct integrative analyses.We identified 105 regulator genes that could...
Abstract To address the limitations of traditional photothermal therapy (PTT)/ photodynamic (PDT) and real-time cancer metastasis detection, a pH-responsive nanoplatform (NP) with dual-modality imaging capability was rationally designed. Herein, 1 H,1 H-undecafluorohexylamine (PFC), served as both an oxygen carrier 19 F magnetic resonance (MRI) probe, photosensitizer indocyanine green (ICG) were grafted onto peptide hexahistidine (H 6 ) to form H -PFC-ICG (HPI). Subsequently, heat shock...
Thyroid nodules (TNs) are highly prevalent worldwide and have a pattern of female predominance. Bisphenol A (BPA) is an endocrine disruptor that can lead to adverse effects in human health. However, epidemiologic studies revealing the association between BPA exposure TNs limited results inconsistent. We aimed examine urinary women who more susceptible TNs.We conducted case-control study with 1416 aged 18 years or older (705 cases, 711 controls). All participants underwent thyroid...
Long non-coding RNA (lncRNA) zinc finger protein 667-antisense 1 (ZNF667-AS1) is closely related to the advancement of a variety cancers, but its functional role in colorectal cancer remains unclear. This study was designed explore function and molecular mechanisms lncRNA ZNF667-AS1 cancer. Reverse transcriptase real-time quantitative polymerase chain reaction (RT-qPCR) used for detection proline-rich nuclear receptor co-activator 2 (PNRC2) expression level. Cell counting kit-8 (CCK-8),...
MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate gene expression at the posttranscriptional level and play an important role in carcinogenesis. Herein, we characterized global of miRNA distal gastric adenocarcinomas determined if circulating miRNAs could be used as biomarkers for adenocarcinoma. We a microarray screening system to detect dysregulated adenocarcinoma tissues. The subset five aberrantly expressed (miR-375, -196b, -204, -18b, -93) were further...
Many reports suggest that the discovery of microRNAs (miRNAs) might provide a novel therapeutical target for many diseases, even human cancers; however, there are no on role miR-597 in cancers. In present study, by detecting mRNA expression with qRT-PCR, compared adjacent normal tissues we found was significantly downregulated breast cancer tissues. By using MTT assay, cell wound-healing assay and invasion demonstrated mimics were able to suppress proliferation, migration invasion....
Increasing evidence has indicated the prognostic value of miR-433 across a series malignancy types. However, underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In present work, we found that was downregulated CRC tissues and cell lines. Ectopic expression obviously suppressed proliferation, invasion metastasis activity cells vitro vivo. CREB1, CCAR1 JNK1 were highly expressed negatively correlated with CRC. patients higher or presented worse outcome...
Background: Carcinoembryonic antigen (CEA) is the most common serum tumor marker in colorectal cancer (CRC). Nevertheless, few previous studies demonstrated impacts of postoperative CEA and post-preoperative increment on prognosis CRC. Methods: Patients with stage II III CRC were included from January 2009 to December 2015. All clinical follow-up data collected. divided into four different groups according levels trends. Chi-square test was used analyze relationship between variables...
Oxidative stress induced disc cell apoptosis plays an important role in intervertebral (IVD) degeneration. The present study aims to investigate effects of resveratrol (RV), a natural polyphenol compound, on sodium nitroprusside (SNP) nucleus pulposus (NP) and related mechanism. Rat NP cells were pretreated with RV, N-acetyl cysteine (NAC) carboxy-PTIO (PTIO) before SNP treatment. Cell Counting Kit-8 assay was carried out for viability evaluation. Annexin V/propidium iodide (PI), Hoechst...
Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix (MMPs) to limit degradation the extracellular matrix. Low levels TIMP3 have been demonstrated in cancer tissues at advanced clinical stages, with positive distant metastasis and chemotherapeutic resistance. We examined role osteosarcoma (OS) cell invasiveness chemoresistance. was overexpressed or knocked down human OS lines Saos2 MG63. Cell migration invasion capacities were then evaluated using Transwell assays, resistance...
Aim: To explore the biological functions and clinicopathologic significance of long noncoding RNA KTN1-AS1 in head neck squamous cell carcinoma (HNSCC). Materials & methods: We assessed effects identified target miRNA by bioinformatics analysis, luciferase reporter, pull-down immunoprecipitation assays. The features its were analyzed HNSCC. Results: KTN1-AS1, a competing endogenous RNA, promoted proliferation, migration, invasion epithelial–mesenchymal transition sponging miR-153-3p...
Background and aim: The miR-196a2 gene contains a C/T polymorphism (rs11614913). Its presence could change the conformation of secondary structure RNA, directly affect binding to target mRNAs miRNA maturation process. Both which eventually alter protein expression contributed cancer susceptibility. This study assessed whether rs11614913 single nucleotide (SNP) an individual's susceptibility esophageal squamous cell carcinomas (ESCC).Methods: SNP was genotyped by polymerase chain reaction...
The aim of the present study was to examine protective effects and mechanism sika deer (Cervus nippon Temminck) velvet antler polypeptides (VAPs) against MPP+ exposure in SH‑SY5Y human neuroblastoma cell line. cytotoxicity VAPs on cells were determined using an MTT assay. Cell apoptosis mitochondrial membrane potential detected Hoechst 33342 Rhodamine123 staining, respectively. Endoplasmic reticulum (ER) stress‑related reactive oxygen species (ROS) production 2',7'‑dichlorodihydrofluorescein...