A5009931827- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Lung Cancer Research Studies
- Laser-Matter Interactions and Applications
- Cancer Genomics and Diagnostics
- Non-Destructive Testing Techniques
- Photonic Crystal and Fiber Optics
- Cancer-related gene regulation
- Dermatologic Treatments and Research
- Welding Techniques and Residual Stresses
- Epigenetics and DNA Methylation
- Sepsis Diagnosis and Treatment
- Advanced Fiber Laser Technologies
- Cardiac Fibrosis and Remodeling
- Laser Applications in Dentistry and Medicine
- Peptidase Inhibition and Analysis
- Posttraumatic Stress Disorder Research
- Medical and Biological Ozone Research
- Child Abuse and Trauma
- Signaling Pathways in Disease
- Gynecological conditions and treatments
Shanghai Ninth People's Hospital
2018-2024
Shanghai Jiao Tong University
2014-2024
Shenyang Pharmaceutical University
2023-2024
Nanjing Medical University
2022-2024
Institute of Psychology, Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Wenzhou City People's Hospital
2019-2024
Beijing Institute of Neurosurgery
2024
Capital Medical University
2024
Weifang Medical University
2019-2023
The lncRNA LINC00460 plays crucial roles in several epithelial cancers, although its mechanisms of action differ greatly different cellular contexts. In this study, we aimed to determine the potential clinical applications and elucidate by which affects development progression head neck squamous cell carcinoma (HNSCC).The biological functions were assessed cancer lines. subcellular localization was evaluated nuclear/cytoplasmic fractionation fluorescence situ hybridization. RNA pull-down...
Abstract Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs PTK7 cancers. In this study, we showed that was significantly correlated with the Wnt/β-Catenin pathway aggressive clinicopathologic features human head neck squamous cell carcinoma (HNSCC). Meanwhile, animal experiments enhanced chemoresistance lung metastasis of HNSCC vivo. addition,...
In our previous studies, enhancer of zeste homolog 2 (EZH2) has been proven to be a key oncogenic driver in oral squamous cell carcinoma (OSCC). However, the regulatory mechanisms on EZH2 remain poorly understood OSCC. Here, through multi-transcriptomics, bioinformatics analysis, and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), co-expression network long noncoding RNA RC3H2 (RC3H2), microRNA-101-3p (miR-101-3p), were screened validated as competing endogenous...
Cisplatin resistance is a major therapeutic challenge in advanced head and neck squamous cell carcinoma (HNSCC). Here, we aimed to investigate the key signaling pathway for cisplatin HNSCC cells. Vomeronasal type-1 receptor 5 (VN1R5) was identified as resistance-related protein highly expressed cisplatin-resistant cells tissues. The long noncoding RNA (lncRNA) lnc-POP1-1 confirmed be downstream target induced by VN1R5. VN1R5 transcriptionally regulated expression activating specificity 1...
Abstract CD 147/basigin ( BSG ) is highly upregulated in many types of cancer, our previous study has found that 147/ expressed head and neck squamous cell carcinoma HNSCC stem cells, but its role the underlying mechanism still unknown. In this study, we investigated 147 progression . Real‐time PCR , western blot immunohistochemistry were used to detect expression total 189 tissues compared with normal tissues. addition, proliferation, colony formation, cycle apoptosis, migration invasion as...
Anlotinib is a new multi-target tyrosine kinase inhibitor (TKI) and has been shown to have antitumor effects synergistic with immunotherapy only in animal studies the 2nd-line treatment small clinical trials. A real-world study large sample compare efficacy safety of anlotinib plus immune checkpoint inhibitors (ICIs) ICIs alone multiline advanced non-small cell lung cancer (NSCLC) was urgently needed.The data 535 NSCLC patients were collected from January 1, 2018, December 31, 2021. The...
The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, it has become increasingly apparent that molecular dysregulation is considerable importance for cellular signaling pathways. Recently, RNA-binding motif protein 47 (RBM47) been suggested to function as a regulator acting an RNA binding (RBP), but its role in HCC remains ambiguous. Here, HCC, we identified RBM47 had inhibitory influence on vitro accordingly...
Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor in oral maxillofacial regions, long noncoding RNAs (lncRNAs) play crucial roles occurrence progression of HNSCC. The lncRNA lnc-H2AFV-1 was found to be upregulated HNSCC tissues; however, function regulating proliferation potential molecular mechanism unclear. present study evaluated expression tissues using quantitative real-time PCR (qPCR) associated abundant with size. Functionally, significantly promoted...
Aim: To explore the biological functions and clinicopathologic significance of long noncoding RNA KTN1-AS1 in head neck squamous cell carcinoma (HNSCC). Materials & methods: We assessed effects identified target miRNA by bioinformatics analysis, luciferase reporter, pull-down immunoprecipitation assays. The features its were analyzed HNSCC. Results: KTN1-AS1, a competing endogenous RNA, promoted proliferation, migration, invasion epithelial–mesenchymal transition sponging miR-153-3p...
Abstract Background We aimed to demonstrate the regulatory effect of long non‐coding RNA (lncRNA) ENAH‐202 on oral squamous cell carcinoma (OSCC) development as well its molecular mechanism. Methods detected expression in OSCC tissues and lines by quantitative real‐time PCR (qPCR). The biological function was assessed vitro vivo using CCK‐8, colony formation assays, transwell xenograft formation, tail vein injection. further mechanism which promoted progression identified pull‐down, LS‐MS/MS...
The trimethylation on histone H3 lysine 27 (H3k27me3), a transcriptionally repressive epigenetic mark of permissive chromatin, can be removed by the demethylase 6a (Kdm6a). However, physiological function H3k27me3 and Kdm6a circadian genes remains largely elusive. With ChIP-Seq mRNA microarray assays, critical role is identified for in regulation to impact expression Crytochrome 1 (Cry1) hypothalamus diet induced obesity mice. More importantly, both conditional knockout pharmacological inhibition
Alectinib is a second generation of ALK-tyrosine kinase inhibitors (ALK-TKIs), which has attracted much attention in the treatment ALK-positive non-small cell lung cancer (NSCLC). At present, there are few reports on efficacy and safety alectinib Chinese population. Moreover, biomarkers reflecting prognosis exceedingly needed. This study assessed patients with NSCLC analyzed prognostic factors.Patients who were confirmed by histopathology or cytology at Affiliated Cancer Hospital Nanjing...
Analytical method for eddy current evaluation is an attractive field of learning the concept electromagnetic phenomena. This paper proposes analytical approach to a transverse displacement sensor with rectangular testing coil. So
Abstract As a new type of displacement sensor, grating eddy current sensor (GECDS) combines traditional sensors and structure in one. The GECDS performs wide range measurement without precision reduction. This paper proposes an analytical modeling approach for the GECDS. solution model is established Cartesian coordinate system, solving domain limited to finite extents by using truncated region eigenfunction expansion method. Based on second order vector potential, expressions...
The present study aimed to discover potential biomarkers for predicting the prognosis of acute respiratory distress syndrome (ARDS) in conjunction with lung ultrasound (LUS). Blood samples from 112 ARDS patients were collected compare their partial oxygen pressure (PaO2)/fraction inspired (FiO2), positive end-expiratory (PEEP), lactic acid, sequential organ failure assessment (SOFA) score, clinical pulmonary infection score (CPIS) and APACHE II score. Kaplan-Meier plots log-rank test...
Cervical cancer is a common malignant gynecological tumor for females all over the world. Circular RNAs (circRNAs) are being found to have relevance various human cancers, including cervical cancer. This study designed explore role and mechanism of circRNA DDB1- CUL4-associated factor 1 (circVPRBP, also known as hsa_circ_0065898) on progression CircVPRBP, microRNA-106b-5p (miR-106b-5p), tripartite motif-containing protein 3 (TRIM3) levels were determined by real-time quantitative PCR. Cell...
N7-methylguanosine (m7G) modification is closely related to the occurrence of tumors. However, m7G circRNAs in oral squamous cell carcinoma (OSCC) remains be investigated. Methylated RNA immunoprecipitation sequencing (MeRIP-seq) was used measure methylation levels and identify sites human OSCC normal tissues. The host genes differentially methylated expressed were analyzed by Gene Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses, circRNA-miRNA-mRNA networks...