A5102993263- Synthesis and biological activity
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Gastric Cancer Management and Outcomes
- Insect Resistance and Genetics
- Lung Cancer Treatments and Mutations
- Protein Tyrosine Phosphatases
- Metastasis and carcinoma case studies
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- RNA regulation and disease
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Insect and Pesticide Research
- Paraoxonase enzyme and polymorphisms
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Domain Adaptation and Few-Shot Learning
- Silk-based biomaterials and applications
- Cancer, Stress, Anesthesia, and Immune Response
- Seismic and Structural Analysis of Tall Buildings
- Macrophage Migration Inhibitory Factor
- Cynara cardunculus studies
- Neurological diseases and metabolism
- Biopolymer Synthesis and Applications
Wuhan University of Technology
2023
University College London
2021-2022
Taiyuan University of Technology
2021
Fujian Agriculture and Forestry University
2019-2021
Institute of Oceanology
2017-2019
Chinese Academy of Sciences
2015-2019
Qingdao National Laboratory for Marine Science and Technology
2017-2019
China Pharmaceutical University
2019
University of Cologne
2014-2017
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2014-2017
Feature Pyramid Networks (FPN) is a popular feature extraction. However, FPN and its variants do not investigate the influence of resolution information semantic in object detection. Thus, cannot detect some objects on challenging images. In this paper, based FPN, we propose to use gaussian kernel function assign different weight values for images The proposed method, called Weighted Network (WFPN), shows significant improvement over traditional pyramids several applications. Using WFPN...
Natural products offered more opportunities to develop new drugs and leading compounds as potent PTP1B inhibitors for treating T2DM.
Poly(ADP-ribose) polymerase-1 (PARP-1) is a new potential target for anticancer drug discovery. A series of bromophenol–thiosemicarbazone hybrids as PARP-1 inhibitors were designed, synthesized, and evaluated their antitumor activities. Among them, the most promising compound, 11, showed excellent selective inhibitory activity (IC50 = 29.5 nM) over PARP-2 > 1000 potent activities toward SK-OV-3, Bel-7402 HepG2 cancer cell lines 2.39, 5.45, 4.60 μM), along with inhibition tumor growth in an...
Anlotinib is a new multi-target tyrosine kinase inhibitor (TKI) and has been shown to have antitumor effects synergistic with immunotherapy only in animal studies the 2nd-line treatment small clinical trials. A real-world study large sample compare efficacy safety of anlotinib plus immune checkpoint inhibitors (ICIs) ICIs alone multiline advanced non-small cell lung cancer (NSCLC) was urgently needed.The data 535 NSCLC patients were collected from January 1, 2018, December 31, 2021. The...
The western flower thrips, Frankliniella occidentalis (Pergande) is a highly invasive pest that able to exploit many crops across wide range of environmental conditions. Five full-length cDNAs heat shock protein (HSP) genes (Fo-HSP90, Fo-HSP70, Fo-HSP60, Fo-HSP40 and Fo-HSP28.9) were cloned from F. occidentalis, their expression profiles investigated under conditions thermal stress insecticide exposure, at different stages during development, using real-time quantitative PCR. All five gene...
Poly- γ -glutamic acid ( -PGA), naturally secreted from various strains of Bacillus , has anti-inflammatory activity. In inflammatory bowel disease (IBD), inflammation is promoted and sustained by angiogenesis; however, the role played -PGA in this condition unclear. Therefore, we evaluated effects on angiogenesis a dextran sulfate sodium- (DSS-) induced mouse colitis model. Experimental was male C57BL/6 mice administering 3% DSS. Disease activity index (DAI), histopathological scores,...
Although mitochondria are ubiquitous, each mitochondrial disease has surprisingly distinctly different pattern of tissue and organ involvement. Congruently, mutations in genes encoding for tRNA synthetases result the development a very flamboyant group diseases. Mutations some these genes, including aspartyl-tRNA synthetase (DARS2), lead to onset white matter disease-leukoencephalopathy with brainstem spinal cord involvement, lactate elevation (LBSL) characterized by progressive spastic...
The m-AAA protease preserves proteostasis of the inner mitochondrial membrane. It ensures a functional respiratory chain, by controlling turnover complex subunits and allowing translation, but other functions in mitochondria are conceivable. Mutations genes encoding have been linked to various neurodegenerative diseases humans, such as hereditary spastic paraplegia spinocerebellar ataxia. While essential for neuronal survival established, its role adult glial cells remains enigmatic. Here,...
To identify the genetic cause of autosomal dominant spinocerebellar ataxia type 28 (SCA28) with ptosis in 2 Belgian families without AFG3L2 point mutations and further extend clinical spectrum SCA28 through study a brain autopsy, advanced MRI, cell-based functional assays exploring underlying disease mechanism.Two large were clinically examined detail. Linkage analysis multiplex amplicon quantification performed. A autopsy was obtained. Brain MRI voxel-based morphometry diffusion tensor...
Diabetes mellitus, including type 1 and 2 diabetes mellitus (2-DM) are the main threats to human health in worldwide. Protein tyrosine phosphatase 1B (PTP1B) is a promising molecular level legitimate therapeutic target effective management of 2-DM. For search potent PTP1B inhibitors, much investigation has revealed large number small-molecule compounds obtained from natural sources or prepared by synthesis/semi-synthesis with various skeletons anti-PTP1B activities treatment Although some...
A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g–4i, 5h, 6d, 7a, 7b) showed potent activity the tested five human lines. Wound-healing demonstrated compound 4g can be used as a inactivating invasion metastasis by inhibiting migration cells. The structure–activity relationships (SARs) had been...
A series of bromophenol hybrids with N-containing heterocyclic moieties were designed, and their anticancer activities against a panel five human cancer cell lines (A549, Bel7402, HepG2, HCT116 Caco2) using MTT assay in vitro explored. Among them, thirteen compounds (17a, 17b, 18a, 19a, 19b, 20a, 20b, 21a, 21b, 22a, 22b, 23a, 23b) exhibited significant inhibitory activity the tested lines. The structure-activity relationships (SARs) derivatives discussed. promising candidate compound 17a...
This work analyzes the impact of transceivers' relative locations on physical layer security achieved by directional modulation with a random frequency diverse array (DM-RFDA). Based adopted path loss model, we first derive probability non-zero secrecy capacity, denoted pn, at legitimate receiver for an eavesdropper fixed location. We then examine how far need to push away from transmitter in order guarantee pn ≥ δ, where δ is given value determining certain level security. The results...
A series of novel fluorinated anticancer agents containing the indolin-2-one moiety were designed, synthesized and evaluated for their activities <italic>in vitro</italic>.
Liriomyza huidobrensis, L. trifolii and sativae (Diptera: Agromyzidae) are serious horticultural pests. The three species very similar difficult to discriminate from each other. In this study, we report the mitochondrial genome of huidobrensis compare with sativae. is 16,239 bp long, it contains 37 genes one A + T-rich region as do sequenced liriomyza species. sequence structure H51-H100 in srRNA significantly different that greatest differences among leafminers located including ND2, ND3,...
Abstract Luteolin is a flavonoid in many fruits and vegetables. Although luteolin has important biological functions, including antioxidant, anti‐inflammatory, antimicrobial, neuroprotective activities, little known about the functions of olfactory system. Various odorants can be detected distinguished by using several molecular processes, binding to odorant receptors, activation adenylyl cyclase (AC), changes cyclic adenosine monophosphate (cAMP) Ca 2+ levels sensory neurons, as well...
The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated, and therapy strategy for stage IB GC patient required further investigation.A total 380 patients with pT2 after radical surgery were retrospectively analyzed, including 185 superficial (sMP) group 195 deep (dMP) group.The overall survival (OS) significantly better sMP than dMP (P = 0.007). In multivariate analysis, invasion, pN stage, age, primary location, positive...