A5084865095- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
Nanjing Medical University
2020-2023
Jiangsu Cancer Hospital
2020-2023
Systemic immune-inflammation index (SII), calculated by immunoinflammatory cell counts of peripheral blood, is considered a predictor survival outcome in several solid tumors, including gastric cancer (GC). However, there no study focusing on the prognostic value SII early stage GC. This aims to compare prediction capabilities inflammatory indices, nutritional and tumor markers further verify superior I-II GC patients after surgery.In this study, 548 (358 training group 190 validation group)...
To investigate the connection between mutant KRAS/NRAS/BRAF and clinicopathological characteristics in therapy-naïve synchronous metastatic colorectal cancer (mCRC) Chinese populations when compared with all wild type (KRAS/NRAS/BRAF type).A total of 200 patients mCRC (TNM stage: TanyNanyM1) were retrospectively collected as study objects. Primary tumor tissues from analyzed through next-generation sequencing panel to assess mutated regions KRAS/NRAS/BRAF.The distribution frequency gene...
To investigate the clinical and pathological features of multiple primary malignant neoplasms (MPMNs) cases.The data 24 105 tumour patients admitted to Jiangsu Cancer Hospital in 2018 were retrospectively reviewed, 270 with MPMNs selected as research subjects. Among them, 101 cases synchronous carcinoma (SC) 92 metachronous (MC) divided into groups for statistical analysis. Univariate multivariate cox regression analyses conducted using SPSS 22.0 software.Among cases, there was a...
Abstract Objective: This study aims to investigate the potential enhancement of diagnostic accuracy in gastric cancer through combined detection serum tumor markers (CST4, CEA, CA72-4, CA125, CA19-9). Additionally, we examine CST4 levels both preoperative and postoperative patients evaluate correlation between burden. Results: In cancer, positive rates CST4, CA19-9 were notably higher (20.34%, 20.76%, 14.41%, 8.9%, 11.44%, respectively) compared those control group (4.35%, 4.35%, 0%, 1.45%,...
Background: Tumor mutation burden (TMB) assessed by tumor-related gene panels (CRGP), microsatellite instability (MSI), and mismatch repair (MMR) has been proven to be associated with prognosis, these factors are prognostic indicators in predicting the benefits of immune checkpoint blockade (ICB) solid tumors. However, whether TMB calculated CRGPs, MSI, MMR is overall survival (OS) patients colorectal cancer (CRC) remains explored. Methods: The threshold panel-TMB was explored a panel 645...
The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated, and therapy strategy for stage IB GC patient required further investigation.A total 380 patients with pT2 after radical surgery were retrospectively analyzed, including 185 superficial (sMP) group 195 deep (dMP) group.The overall survival (OS) significantly better sMP than dMP (P = 0.007). In multivariate analysis, invasion, pN stage, age, primary location, positive...
Abstract Purpose: The purpose of this study was to evaluate the value circulating cell-free DNA (cfDNA) as a biomarker for predicting efficacy first-line chemotherapy in patients with metastatic colorectal cancer (mCRC). Methods: A total 118 mCRC who received Jiangsu Cancer Hospital from July 2018 April 2020 were enrolled. CfDNA quantitatively detected plasma collected before and during chemotherapy. Correlations between cfDNA baseline levels clinicopathological characteristics, kinetics...
Abstract We retrospectively enrolled 325 gastric cancer (GC) patients to investigate the associations of programmed death ligand‐1 (PD‐L1) expression with clinicopathological characteristics by different scoring methods and cutoff values. PD‐L1 was evaluated tumor proportion score (TPS) combined positive (CPS). The rate TPS ≥1%, CPS ≥1, ≥5 ≥10 in our study were 12.0%, 87.4%, 69.8% 42.2%, respectively. Multivariate analysis showed that related high Ki67 (OR = 2.658, 95% CI: 1.401–5.045, p...
Abstract Background The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated. Methods A total 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 superficial (sMP) group and 195 deep (dMP) group. Results overall survival (OS) significantly better for sMP than dMP (P=0.007). In multivariate analysis, invasion, pN stage, age, primary location, positive expression p53, elevated maximal LDH,...
Background: This study investigated the survival difference and clinicopathological characteristics according to depth of tumor muscularis propria involvement in gastric cancer (GC) found biomarkers reinforce prognostic therapy-guided ability TNM staging system. Methods: A total 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 superficial (sMP) group 195 deep (dMP) group. Findings: The overall (OS) sMP was significantly better than dMP (P=0·007). In...