A5100740929- Gut microbiota and health
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Cell death mechanisms and regulation
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Gastrointestinal Tumor Research and Treatment
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- RNA regulation and disease
- Intensive Care Unit Cognitive Disorders
- Ocular Oncology and Treatments
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- RNA Interference and Gene Delivery
- Bioactive Compounds and Antitumor Agents
- Metastasis and carcinoma case studies
- Oral microbiology and periodontitis research
- Brain Tumor Detection and Classification
- Photodynamic Therapy Research Studies
Chongqing Medical University
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
First Affiliated Hospital of Harbin Medical University
2021-2023
Xiamen University
2023
Shandong First Medical University
2023
Harbin Medical University
2021-2023
Nanjing Medical University
2021-2023
Fujian Medical University
2023
Jiangsu Cancer Hospital
2023
Zhangjiakou Academy of Agricultural Sciences
2023
Pyroptosis, an inflammatory form of programmed cell death, is the initiating event sepsis and results in immune imbalance by releasing IL‐1 β IL‐18 early stages. Studies show that enhancing autophagy via genetic manipulation can inhibit pyroptosis prolong survival a animal model, indicating possible therapeutic strategy against sepsis. However, almost no study so far has achieved inhibition pharmacological induction disease model. To this end, we established vitro model stimulating primary...
Objective This study explored the potential molecular mechanisms of ursolic acid (UA) in bladder cancer treatment using network pharmacology and docking. Methods The Traditional Chinese Medicine Systems Pharmacology UniProt databases were used to screen targets UA. Relevant target genes extracted GeneCards database. All data pooled intercrossed obtain common UA cancer. Gene Ontology functional annotation Kyoto Encyclopedia Genes Genomes pathway enrichment analyses performed. Molecular...
Retinal vessel segmentation in fundus images plays an essential role the screening, diagnosis, and treatment of many diseases. The acquired generally have following problems: uneven illumination, high noise, complex structure. It makes very challenging. Previous methods retinal vascular mainly use convolutional neural networks on U Network (U-Net) models, they limitations shortcomings, such as loss microvascular details at end vessels. We address convolution by introducing transformer into...
Ovarian cancer (OC) is a type of with high prevalence and shocking mortality in women around the world. Radioresistance major reason for OC relapse. Mounting studies have shown significant function dysregulated microRNAs (miRNAs) progression cellular response to irradiation. The present study inquired about mechanism microRNA (miR)-4478 regulating radiosensitivity cells. Results showed that miR-4478 was downregulated OC, low level indicated disappointing prognosis patients. Besides, cells...
Upregulation of Sirtuin Type 1 (SIRT1), a nicotinamide adeninedinucleotide (NAD+)-dependent deacetylase, has been proved to protect against ample ocular diseases, while its effect on retinitis pigmentosa (RP) not illustrated. The study was aimed explore the impacts resveratrol (RSV), SIRT1 activator, photoreceptor degeneration in rat model RP induced by N-methyl-N-nitrosourea (MNU), an alkylation. rats were phenotypes via intraperitoneal injection MNU. electroretinogram conducted and...
Purpose: The calcium-sensing receptor (CaSR) acts as a major modulator of tissue responses related to calcium homeostasis and expresses highly in the mammalian intestine. Endotoxemia tends impair intestinal barrier function poses significant obstacles clinical treatment. This work is designed decipher whether CaSR can protect lipopolysaccharide (LPS)-induced dysfunction neonatal rats by targeting metabolites. Patient Methods: In this study, we utilized gas chromatography (GC) combined with...
Background: Accumulating evidence suggests a connection between the gut microbiota and neonatal diseases. Hypoxia may play an important role in intestinal lesions neonates. Objective: This study aims to determine whether differs intrauterine hypoxic rats healthy controls identify factors that influence changes microbiota. Methods: We constructed hypoxia model collected contents of newborn normal within 4 h on seventh day after birth. They were divided them into first-day group (INH1),...
ABSTRACT Hypoxia, which activates the hypoxia inducible factor 1α (HIF‐1α), is an essential feature of retinoblastoma (RB) and contributes to poor prognosis resistance conventional therapy. In this study, effect HIF‐1α knockdown by small interfering RNA (siRNA) on cell proliferation, apoptosis, apoptotic pathways human Y‐79 RB cells was first investigated. Exposure induced increased expression both in mRNA protein levels. Then, siRNA resulted inhibition proliferation apoptosis under normoxic...
Abstract Objective: This study aims to investigate the potential enhancement of diagnostic accuracy in gastric cancer through combined detection serum tumor markers (CST4, CEA, CA72-4, CA125, CA19-9). Additionally, we examine CST4 levels both preoperative and postoperative patients evaluate correlation between burden. Results: In cancer, positive rates CST4, CA19-9 were notably higher (20.34%, 20.76%, 14.41%, 8.9%, 11.44%, respectively) compared those control group (4.35%, 4.35%, 0%, 1.45%,...
Background: Growing evidence points to an association between the gut microbiota and neonatal diseases. Calcium-sensing receptor (CaSR) is a major modulator of tissue responses associated with calcium homeostasis highly expressed in mammalian gut. CaSR may affect composition balance intestinal microenvironment. Methods: Neonatal rats were randomized control, lipopolysaccharide (LPS), agonist, inhibitor groups. The contents collected within 24 hours or 7 days after intervention. Then, 16S...
Objective To study the role of HRAD17 in DNA damage and apoptosis induced by ionizing radiation. Methods Plasmids including pDOR-neo vector,pDORHRAD17s(sense) pDOR-HRAD17a(anti-sense) were transfected into mouse fibroblasts(NIH3T3) human uterine cervix cancer cells(HeLa).Positive clones screened G418.After 48 h serume-free culture,all kinds cells exposed to 10 Gy γ-rays(at 2.54 Gy/min) immediately cultured with serum.The isolated fixed 70% ethanol,with collected at 0,6,12,24,36...