A5100414473- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- Optimism, Hope, and Well-being
- Health and Wellbeing Research
- HIV-related health complications and treatments
- Perfectionism, Procrastination, Anxiety Studies
- Renal and related cancers
- TGF-β signaling in diseases
- PI3K/AKT/mTOR signaling in cancer
- Enhanced Recovery After Surgery
- Tissue Engineering and Regenerative Medicine
- Pediatric health and respiratory diseases
- Ferroptosis and cancer prognosis
- Pulmonary Hypertension Research and Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Medical Research and Treatments
- RNA Interference and Gene Delivery
- Uterine Myomas and Treatments
- Moyamoya disease diagnosis and treatment
Xiangya Hospital Central South University
2025
Central South University
2015-2025
Binzhou Medical University
2021-2023
Binzhou University
2021-2023
First People’s Hospital of Jingmen
2022
Harbin Medical University
2016-2020
National Health and Family Planning Commission
2020
The Seventh Affiliated Hospital of Sun Yat-sen University
2020
Sun Yat-sen University
2019-2020
Third Affiliated Hospital of Harbin Medical University
2020
Ferroptosis is a type of iron‑dependent regulated cell death that differs from apoptosis, autophagy or necrosis. p23 serves as co‑chaperone and performs unique biological function in various diseases by binding to client proteins modulate their functions; however, its effect on ferroptosis remains largely unknown. In the present study, effects cerebral ischemia/reperfusion (I/R) injury (CIRI) oxygen‑glucose deprivation/reoxygenation blood‑brain barrier (BBB) brain microvascular endothelial...
Background: Rheumatoid arthritis (RA) is a inflammatory disease that characterized with the destruction of synovial joint, which could induce disability. Inflammatory response mediated RA. It has been reported MiR-128-3p significantly increased in RA, while potential role was still unclear.Methods: T cells peripheral blood mononuclear cell (PBMC) were isolated from people RA and normal person used. Real-time PCR performed to detect expression MiR-128-3p, protein tumor necrosis...
Background/Aims: The etiology of asthma, which is a complicated disorder with various symptoms, including wheezing, coughing, and airflow obstruction, remains poorly understood. In addition, the effects microRNAs (miRs) have not been explored. This study explored effect microRNA-200a (miR-200a) on airway smooth muscle cells (ASMCs) remodeling in asthmatic mice. Furthermore, we speculated that miR-200a achieves its by targeting FOXC1 via PI3K/AKT signaling pathway based differentially...
miRNA-200c can not only inhibit the aggressiveness of cancer cells but also increase sensitivity to antitumor drugs. However, some mechanisms are still unclear. Recent researches revealed that E-cadherin is more than an inhibitor metastasis, and it plays important roles in reversing drug resistance. We had previously found could induce expression gastric SGC7901/DDP cisplatin (DDP). This study aimed explore effects on biological characteristics regulatory pathway miRNA-200c.SGC7901/DDP its...
Objective: Sepsis poses a serious global health problem with an overall mortality rate of 30%, in which the vascular injury is major contributor. The study to determine expression profile micro-RNAs endotoxic walls and their potential roles sepsis-related injury. Design: Prospective randomized study. Setting: Laboratory investigation. Subjects: Male C57BL/6 mice, average weight 26.5 ± 1.8 g. Interventions: Endotoxemia was induced mice via lipopolysaccharide injection (20 mg/kg,...
Both HIV and antiretroviral therapy could induce vascular aging with unclear mechanisms. In this study, via microarray analysis, we identified, for the first time, that miR-34a expression was significantly increased in both HIV-infected, agents-treated vessels endothelial cells (ECs) from these vessels. cultured ECs, by HIV-Tat protein agents, lopinavir/ritonavir. agents EC senescence, which inhibited inhibition. contrast, senescence exacerbated overexpression. addition, ECs isolated...
Dysregulation of a numerous microRNAs (miRNAs) has been implicated in laryngeal squamous cell carcinoma (LSCC). Among those miRNAs, miR‑21 and miR‑221 are co‑overexpressed commonly target the phosphatase tensin homolog protein (PTEN) that is located PTEN‑Akt signaling pathway. The present study investigated whether co‑inhibition induced synergistic apoptosis human LSCC cells. Methyl thiazolyl tetrazolium (MTT) terminal deoxynucleotidyl‑transferase‑mediated deoxynucleotide triphosphate nick...
Background: Few individuals have focused on the experience of students during social events, especially among college with anxiety disorder. This study aimed to explore disorder in situations. Methods: qualitative interpretive was conducted who were diagnosed (SAD) and recruited from two colleges Heilongjiang Province, China. A total 7 participants selected by purposive sampling maximum variability. Data collected through semistructured individual interviews, data analysis performed using...
Abstract Background This study intended to investigate the potential mechanism of microRNA‐200c‐3p (miR‐200c‐3p) and miR‐485‐5p in mediating cisplatin (DDP) resistance non–small cell lung cancer (NSCLC). Methods Quantitative real‐time polymerase chain reaction (qRT‐PCR) was applied measure expression miR‐200c‐3p, miR‐485‐5p, ribonucleotide reductase regulatory subunit M2 (RRM2) messenger RNA (mRNA). 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay used analyze DDP...
Activation of the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway induces glial differentiation glioblastoma (GBM) cells, but mechanism by which microRNA (miRNA) regulate this process remains poorly understood. In study, performing miRNA genomics and loss- gain-of-function assays in dibutyryl-cAMP-treated GBM we identified a critical negative regulator, hsa-miR-1275, that modulates set genes involved cancer progression, stem cell maintenance, maturation differentiation....
MicroRNAs (miRNAs) was confirmed to play an active role in the pathogenesis of prostate cancer (PCa). The expression and biological function for miR-92a PCa remains unknown. In this study, we demonstrated that decreased tissues cells lines. Overexpression inhibited cell viability, migration invasion PC-3 while inhibition led opposite alteration viability metastasis DU-145 cells. Mechanically, interacted with 3'-UTR SOX4 through complementary sequences by luciferase reporter assay. qRT-PCR...
Ovarian cancer (OC) is a type of with high prevalence and shocking mortality in women around the world. Radioresistance major reason for OC relapse. Mounting studies have shown significant function dysregulated microRNAs (miRNAs) progression cellular response to irradiation. The present study inquired about mechanism microRNA (miR)-4478 regulating radiosensitivity cells. Results showed that miR-4478 was downregulated OC, low level indicated disappointing prognosis patients. Besides, cells...
The biological function of the intronic microRNA-28 (miR-28) may be associated with roles its host gene, LIM domain lipoma‑preferred partner (LPP). LPP has been reported to promote smooth muscle cell migration in arterial injury and atherosclerosis. However, mechanism miR‑28 atherosclerosis remains unclear. In current study, aim was validate inhibitory effect miR‑28‑5p on extracellular signal‑regulated kinase 2 (ERK2), investigate role association cardiovascular disease. Western blotting...
miR-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and thought to be a related diagnostic marker. Previous studies have indicated the effects of iodine on oncogenic activation. However, effect proliferation PTC cells associated underlying mechanisms remain unclear. We found that was downregulated smad4 upregulated patients exposed high concentration by situ hybridisation (ISH) immunohistochemical (IHC). NaI (10 −3 M) treatment Smad4 cell lines. Luciferase assay used confirm...
Chronic obstructive pulmonary disease (COPD), a progressive and irreversible respiratory disease, becomes the third leading cause of death results in enormous economic burden on healthcare costs productivity loss worldwide by 2020. Thus, it is urgent to develop effective anti-COPD drugs.In present study, two published GEO profiles were used re-analyze ascertain relationships between circulating miRNAs bronchial epithelial cells (BECs) mRNAs COPD. The microRNA levels miR-361-5p miR-196-5p...
This study intended to explore the nursing outcome-oriented intervention's effect on airway management in elderly long-term bedridden patients.A total of 120 cases patients admitted our hospital from May 2018 June 2020 were enrolled and randomly divided into observation group (n = 60) control 60). The received routine intervention, while intervention. Forced expiratory volume (FEV1), forced vital capacity (FVC), maximal voluntary ventilation (MVV) first second compared between two groups...
The fertility of females childbearing age who are cured cancer by chemotherapy is gradually declining globally. As a broad-spectrum drug in clinic, the damage cisplatin (CDDP) to female reproductive function cannot be ignored. At present, study CDDP uterus not sufficient, and exact mechanism needs further explored. Therefore, we conducted this research determine whether uterine injury CDDP-induced rats might improved human umbilical cord mesenchymal stem cells (hUMSCs) explore precise...
Objective. To explore the application effect of nursing outcome-oriented integrated zero-defect combined with respiratory function training in long-term bedridden patients stroke. Methods. A total 120 stroke were randomly divided into three groups: groups A, B, and C. Group was given training, group B nursing, C routine nursing. Rosenbek aspiration degree classification criteria used to evaluate incidence aspiration; blood oxygen saturation, arterial partial pressure, pressure compared...