Abstract Background There is mounting proof that rheumatoid arthritis (RA) and cognitive decline are related. These studies, however, have not all been uniform, others discovered such a correlation. It essential to investigate the link between RA decline. Method We conducted Mendelian randomization analysis utilizing three different publicly accessible GWAS summary datasets variety of meticulously verified instrumental variables. mostly used inverse variance weighting (IVW), as well...

Recently, much attention has been paid to the role of neuromuscular function in long-distance running performance. Complex Training (CT) is a combination training method that alternates between performing heavy resistance exercises and plyometric within one single session, resulting great improvement adaptation. The purpose this study was compare effect CT vs. (HRT) on strength power indicators, economy (RE), 5-km performance well-trained male distance runners.Twenty-eight runners (19-23...

Abstract Li, F, Newton, RU, Shi, Y, Sutton, D, and Ding, H. Correlation of eccentric strength, reactive leg stiffness with running economy in well-trained distance runners. J Strength Cond Res 35(6): 1491–1499, 2021—Neuromuscular characteristics play a critical role performance; however, their relationship (RE) remains unclear. The purpose this study was to evaluate the correlations between 1 repetition maximum (1RM) stiffness, RE at 12–16 km·h −1 among male Twenty-eight collegiate runners...

Summary Geothermal energy is regarded as a promising and attractive alternative to traditional sources, with the concept of enhanced geothermal systems (EGS) enabling viable commercial development. EGS modeling requires integration multiscale, multiphysics processes, necessitating comprehensive numerical model effectively evaluate heat extraction performance. The advantages explicitly representing fracture networks directly simulating thermal-hydrologic-mechanical (THM) coupling coupled...

Objective: Although previous epidemiological studies have reported substantial links between inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), celiac (CeD), the causal relationship two remains unknown. The purpose of current study was to evaluate bidirectional causation IBD CeD using Mendelian randomization (MR). Method: We obtained genome-wide association (GWAS) summary data (CD UC) thoroughly European ancestry from IEU GWAS database. screened eligible...

Object Though significant correlations between rheumatoid arthritis (RA) and hypothyroidism have been found in earlier observational studies, their underlying causal relationship is still unknown. Mendelian randomization (MR) was used the current study to assess bidirectional causation RA hypothyroidism. Method We gathered summary data from genome-wide association studies (GWASs) of people European descent. Then, using FinnGen consortium, we replicated our findings. Three approaches were...

Abstract Background Helicobacter pylori (H. pylori), according to a number of recent observational studies, is connected atherosclerosis (AS). However, the link between H. and AS debatable. Methods In order calculate causal relationship AS, we employed two-sample Mendelian randomization (MR) analysis. The data for were obtained from IEU GWAS database ( https://gwas.mrcieu.ac.uk/datasets/ ) Finngen https://r5.finngen.fi/ ). We selected single nucleotide polymorphisms with threshold 5 × 10 –6...

Abstract Background The interrelation between metabolic syndrome (MetS) and Parkinson’s disease (PD) likely arises from shared pathological mechanisms. This study thus aims to examine the impact of MetS its components on PD. Methods utilized data extracted National Health Nutrition Examination Survey database spanning 1999 2020. random forest algorithm was applied fill in missing data. Propensity score optimal full matching conducted. were adjusted by total weights derived both sampling...

Microinflammation is linked to an increased risk of death due cardiovascular disease (CVD) in patients with end-stage renal (ESRD). Although the fibrinogen/albumin ratio (FAR), a novel inflammatory marker, has been shown predict mortality various diseases, limited evidence available for its role ESRD. The purpose this study explore prognostic value FAR ESRD on peritoneal dialysis (PD).

Abstract Marathon performance is influenced by factors such as aerobic capacity and those related to neuromuscular function. Complex training (CPX) a multicomponent method, wherein heavy strength plyometric exercises alternate within single session an effective method improve adaptations. This study compared the effects of CPX, (HST) endurance‐strength (EST) combined with running endurance on adaptations in 38 recreational marathoners (age:31.4 ± 3.8 years, VO 2max :57.6 6.8 ml·kg −1 ·min )....

The aim of this study was to compare the difference between proximal femoral bionic nail (PFBN) and hip replacement (HR) for intertrochanteric fracture.

Objective . The metabolic effects of syndrome (MetS) on musculoskeletal metabolism are controversial. This study explored the effect MetS bone mineral density (BMD) and muscle quality index (MQI). Methods Data from NHANES database 2011 to 2014 were extracted, nonpregnant participants aged 45–59 years included. included data first weighted by complex sampling, then, BMD MQI was analyzed using multifactorial linear regression. We then performed a stratified analysis gender BMI classification....

ZeXie Decoction (ZXD) is one of the traditional Chinese medicine formulas (TCMFs) comprising Alisma orientalis (Sam.) Juzep. (ZX) and Atractylodes macrocephala Koidz. (BZ) in 5:2 ratios widely employed clinical applications since ancient times. In this study, UHPLC-QE-Orbitrap-MS was used for qualitative analysis ZXD rats' plasma after a single oral dose 750 mg/kg body weight. Afterward, UHPLC-Q-TRAP-MS/MS simultaneous three bioactive chemical compounds including alisol A, B, A 24-acetate...

Gross motor coordination (GMC) plays a crucial factor in children's development and daily activities. It encompasses various sub-capacities, such as spatial orientation, rhythm, reaction, collectively referred to basic capacities (BCC). However, children who are overweight obese (OW/OB) often display poorer GMC. This study aims examine the impact of gender weight status (BMI categories) on GMC BCC. also seeks investigate BCC BMI

Observational studies have shown a link between autoimmune diseases and schizophrenia, with conflicting conclusions. Due to the existence of confounding factors, causal schizophrenia is still unknown. We conducted comprehensive Mendelian randomization (MR) analysis ten common in individuals European descent using genome-wide association (GWASs). To evaluate relationships inverse variance weighted, MR-RAPS, Bayesian weighted MR, constrained maximum likelihood, debiased IVW, MR-Egger, median...

There is a growing body of evidence suggesting correlation between sarcopenia (SP) and cognitive impairment (CI), but with conflict. This study employed bidirectional Mendelian randomization (MR) approach to ascertain the causality SP CI.

Hepatic reactive lymphoid hyperplasia (RLH) is a rare benign tumor of the liver that exhibits similar imaging characteristics to those other hepatic malignant tumors; therefore, it requires novel biomarkers be differentiated from tumors. A 69-year-old female was found have mass in and admitted Peking Union Medical College Hospital for further evaluation. Most laboratory tests, including function biomarkers, autoimmune markers were within normal range, except positive antinuclear antibody...

ABSTRACTABSTRACTObjectives The growing global burden of pain is gradually expanding from the medical field to public health. Dietary inflammatory potential correlates with markers, and inflammation one main mechanisms pain.Methods This study explored association between dietary index (DII) NHANES database on DII (neck pain, low back joint headache or migraine) using logistic regression stratified analysis.Results results show a stronger (Q4 adjusted-OR = 1.23, 95% CI 1.08–1.40, P 0.003)...

To introduce the methods of retrograde anterolateral thigh flaps in repairing anterior knee joint wounds under concept precise flap surgery and to explore clinical effects.

To explore the situation of 8 common respiratory pathogens in children with acute infection (ARI) from 2021 to 2022.The retrospective study selected 710 ARI patients September August 2022 Maternal and Child Health Hospital Gansu Province as object, aged 0 17 years old, including 5 048 male 3 662 female children. Indirect immunofluorescence was used detect pathogens, influenza virus A (FluA), B (FluB), parainfluenza (PIV), syncytial (RSV), adenovirus (ADV), Mycoplasma pneumoniae (MP),...

Abstract Background: Protracted withdrawal symptoms(PWS) play a crucial role in relapse. While medication maintenance or behavioral therapies such as cognitive therapy (CBT) can alleviate these symptoms, their implementation is still limited. Evidence suggests that Chinese tuina / massage improve mood and sleep quality individuals experiencing PWS. However, high-quality, evidence-based studies supporting this claim are lacking. Methods analysis A prospective, parallel, three-armed,...