A5100691971- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Natural product bioactivities and synthesis
- Dementia and Cognitive Impairment Research
- Ocular Surface and Contact Lens
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Stroke Rehabilitation and Recovery
- Flavonoids in Medical Research
- Synthesis and biological activity
- Curcumin's Biomedical Applications
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Jinan University
2025
Shanghai Research Center for Acupuncture and Meridians
2020-2025
Qilu Hospital of Shandong University
2025
Qingdao Binhai University
2025
Northeast Agricultural University
2024
China Pharmaceutical University
2014-2024
State Key Laboratory of Natural Medicine
2014-2024
First Affiliated Hospital of Zhengzhou University
2024
Nanjing Medical University
2023-2024
Dalian Medical University
2024
Acute lung injury (ALI) from a variety of clinical disorders, characterized by diffuse inflammation, is cause acute respiratory failure that develops in patients all ages. Previous studies reported wogonin, flavonoid-like chemical compound which was found Scutellaria baicalensis, has anti-inflammatory effects several inflammation models, but not ALI. Here, the vivo protective effect wogonin amelioration lipopolysaccharide (LPS) -induced and assessed. In addition, vitro mechanisms were...
Emerging evidence suggests that NLRP3 inflammasome provides a link between colitis-associated colorectal cancer and inflammatory bowel diseases. Autophagy is induced in macrophages by AMPK activation regulates to maintain intracellular homeostasis. Here we report small-molecule activator (GL-V9) exerts potent anti-inflammatory effects on invitro vivo, which trigger autophagy degraded inflammasome. Treatment with GL-V9 protected against colitis tumorigenesis cancer. This may be an interesting...
Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment facilitates tumor metastasis. Clinically, it will be a promising choice to suppress metastasis by targeting microenvironment. Our previous have wogonin (a bioflavonoid isolated traditional Chinese medicine of Huang‐Qin) possesses anti‐metastatic anti‐inflammatory activity, but we little idea about its efficacy on inflammatory‐induced mechanism underlying it. In this...
Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds of immunological diseases including colitis. However, there are few drugs targeting inflammasomes in the treatment Several flavonoids have been found to affect pathway, but mechanism is still confusing. Here we report VI-16, a synthetic flavonoid compound, exerts potent anti-inflammatory effects on macrophages DSS-induced colitis mice, which intervened activation without affecting intestinal epithelial...
Abstract Background Muscle weakness is a key factor in the increase risk of falls and might also play significant role hip fracture. Computed tomography‐measured muscle size density are well‐established imaging biomarkers used studies physical function, frailty or cancer, but limited to In particular, it warranted have better understanding performance discrimination acute fractures. We aim determine age‐related differences healthy controls fracture patients. Methods Four hundred thirty‐eight...
Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which is the basis of many chronic diseases. Although regulatory mechanism has been gradually clarified after a long period research, metabolic regulation still mystery. Here, we find that ALDOA, as monitor glycolysis, regulates by sensing changes glycolytic flux to participate formation AXIN-based AMPK-activation complex on lysosomal surface. In this process, ALDOA restricts PRKN/parkin-dependent mitophagy...
Curcumin has been observed to exhibit an anti-fibrotic effect in the liver, lung and gallbladder. However, mechanisms underlying cytoprotective effects of curcumin remain be elucidated. The epithelial‑to‑mesenchymal transition (EMT) mature tubular epithelial cells kidney is considered contribute renal accumulation matrix proteins associated with diabetic nephropathy. EMT also closely progression interstitial fibrosis oxidative stress. This process may occur through abrogation high glucose...
The inflammatory microenvironment has been reported to be correlated with tumor initiation and malignant development. In the previous studies we have found that wogonoside exerts anti-neoplastic anti-inflammatory activities. this study, aimed further investigate chemopreventive effects of on colitis-associated cancer delineated potential mechanisms. azoxymethane initiated dextran sulfate sodium (AOM/DSS) promoted colorectal carcinogenesis mouse model, significantly reduced disease severity,...
Bromophenol is a type of natural marine product. It has excellent biological activities, especially anticancer activities. In our study searching for potent drugs, novel bromophenol derivative containing indolin-2-one moiety, 3-(4-(3-([1,4'-bipiperidin]-1'-yl)propoxy)-3-bromo-5-methoxybenzylidene)-N-(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-102) was synthesized, which showed activities on human lung cancer cell lines. A the mechanisms indicated that BOS-102 could significantly block...
Varicella-zoster virus (VZV) infects 85 million individuals annually and it is known for its intricate interplay with host cellular mechanisms, significantly impacting antiviral immune responses. Previous studies have highlighted the critical role of VZV glycoprotein E (gE) in virus-host interactions, but precise mechanisms remain to be elucidated. Our results demonstrate that gE interacts STING, specifically through (350-480aa) STING (151-160aa) regions. This interaction predominantly...
Identifying small pulmonary nodules during sublobar resection via video-assisted thoracoscopic surgery (VATS) poses certain challenges. Although preoperative computed tomography (CT)-guided localization is common, it invasive and may lead to complications. This study aims develop a novel, non-invasive technique for improving the accuracy of nodule VATS, with goal reducing complications associated traditional methods. We developed longitude-latitude-depth (LLD) method, novel intraoperative...
To investigate the incidence patterns and risk factors of acute abdominal pain following hepatic arterial infusion chemotherapy (HAIC) in liver cancer patients develop a preliminary prediction model for post-HAIC pain. Four hundred hepatocellular carcinoma who underwent HAIC at Affiliated Cancer Hospital Shandong First Medical University from January 2021 to March 2023 were retrospectively analyzed. The categorized into two groups (abdominal no pain) based on occurrence moderate severe...
A new species of coccoid methanogen was isolated from the surface sediments Tar Pit Lake at LaBrea Pits in Los Angeles, Calif. Surface colonies strain ZT (= OGC 1T) (T = type strain) were tan, circular, clear, and convex with entire edges. The cells irregular, nonmotile, (diameter, 0.4 to 2.0 µm) grew by producing methane H2-CO2 or formate but not methanol, methylamines, acetate. They exhibited a negative Gram reaction, had protein cell walls, susceptible lysis sodium dodecyl sulfate. over...
The present study was designed to implement an interprofessional simulation-based education program for nursing students and evaluate the influence of this on students' attitudes toward knowledge about operating room nursing. Nursing were randomly assigned either or traditional course group. A before-and-after conducted using Readiness Interprofessional Learning Scale. Responses open-ended question categorized thematic content analysis. measured. from group showed statistically different...
Disease-modifying antirheumatic drugs (DMARDs) are the first line medications to treat rheumatoid arthritis (RA), a chronic and systemic autoimmune disease affecting multiple joints. Sinomenine (SIN) is thought natural DMARD (nDMARD) effectively utilized RA in clinic for several decades China. Here we reported that it not methotrexate (MTX), representative drug of DMARDs, but SIN protected joints from destruction alleviate symptoms mice with arthritis, indicating underlying mechanism...