A5100343252- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- dental development and anomalies
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Multiple Sclerosis Research Studies
- Periodontal Regeneration and Treatments
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Mesenchymal stem cell research
- Sirtuins and Resveratrol in Medicine
- Herpesvirus Infections and Treatments
- Genetics and Neurodevelopmental Disorders
- Nuts composition and effects
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
Hunan University of Traditional Chinese Medicine
2023-2025
Beijing Institute of Genomics
2017-2024
Chinese Academy of Sciences
2017-2024
Fujian University of Traditional Chinese Medicine
2020-2024
Women's Hospital, School of Medicine, Zhejiang University
2023
The First People’s Hospital of Lianyungang
2023
Xuzhou Medical College
2022
Jinan University
2021
Second Affiliated Hospital of Nanjing Medical University
2021
Tianjin Hospital
2020
Tuberculosis (TB) has been the leading lethal infectious disease worldwide since 2014, and about one third of world's population latent TB infection (LTBI). It is largely attributed to difficulties in diagnosis treatment LTBI patients. Exosomes offer a new perspective on investigation process infection. In this study, we performed small RNA sequencing explore profiles serum exosomes derived from patients healthy controls (HC). Our results revealed distinct miRNA profile three groups. We...
Background . Mesenchymal stem cell‐derived exosomes (MSC‐exos) have been recognized as a promising therapeutic strategy for neonatal hypoxic‐ischemic brain damage (HIBD). Recently, microglial pyroptosis was shown to play vital role in the progression of HIBD. However, whether MSC‐exos improve HIBD by regulating remains unknown. Methods. Exosomes were isolated from human umbilical cord mesenchymal cells (huMSCs) and identified transmission electron microscopy (TEM), western blot, nanoparticle...
Curcumin has been observed to exhibit an anti-fibrotic effect in the liver, lung and gallbladder. However, mechanisms underlying cytoprotective effects of curcumin remain be elucidated. The epithelial‑to‑mesenchymal transition (EMT) mature tubular epithelial cells kidney is considered contribute renal accumulation matrix proteins associated with diabetic nephropathy. EMT also closely progression interstitial fibrosis oxidative stress. This process may occur through abrogation high glucose...
Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support an appropriate immunological adjuvant. In study, we investigate potential totally synthetic palmitoyl-tailed helper-cytotoxic-T-lymphocyte chimeric epitopes (Th-CTL lipopeptides) to induce herpes simplex virus type 1 (HSV-1)-specific T-cell responses. As model antigen, HSV-1...
Tuberculosis (TB) has exceeded HIV as the most lethal infectious disease globally for two consecutive years. Moreover, one third of world's population is estimated to have latent tuberculosis infection (LTBI). This mainly because difficulties associated with diagnosis and treatment both TB LTBI patients. Exosomes provide a promising research tool they are released from various cells containing valuable biochemical information related disease. In this study, we performed RNA-sequencing...
Background: Arsenic compounds have modest cytotoxic activity in solid tumors. We investigated if arsenic sulfide (As 4 S ) combination with other distinct agents could enhance its activity. Methods: used gastric and colon cancer cell lines to study the synergistic effect of As BRD4 inhibitor JQ1, or chemotherapy drug cisplatin irinotecan COX2 celecoxib. mechanism these novel combinations. Results: found that when was combined cisplatin, celecoxib, dramatically enhanced both lines. JQ1...
We studied the phenotype and distribution of "naturally" occurring CD4(+) CD25(+) T regulatory cells (CD4(+) nT(reg) cells) resident in rabbit conjunctiva, main T-cell inductive site ocular mucosal immune system, we investigated their suppressive capacities using herpes simplex virus type 1 (HSV-1)-specific effector (T(eff)) induced during infection. The expression CD4, CD25, CTLA4, GITR, Foxp3 was examined by reverse transcription-PCR, Western blotting, fluorescence-activated cell sorter...
Ouabain has been used for the treatment of heart failure and atrial fibrillation. Its potential anticancer effect also attracted great interest. The aim present study was to evaluate ouabain investigate its molecular target. effects on viability induction cellular death OS‑RC‑2 renal cancer cells were examined using MTT assay acridine orange/ethidium bromide staining. levels Ca2+ reactive oxygen species determined Fura‑3‑acetoxymethyl ester dichloro‑dihydro‑fluorescein diacetate probes,...
Gastric and colon cancers have been the leading causes of cancer mortality in world with limited therapy. Small molecules binding to bromodomains bromodomain-containing protein 4 (BRD4) exert strong antitumor activities against hematological malignancies, while generally efficacy advanced solid tumors. Here, we found that bromodomain extra-terminal (BET)-bromodomain inhibitor JQ1, when combined arsenic sulfide (As4S4, abbreviated as AS), synergistically decreased expression nuclear factor...
Gastric carcinogenesis is a multistep process and the second-highest cause of cancer death worldwide with high incidence invasion metastasis. MicroRNAs (miRNAs) engage in complex interactions machinery that controls transcriptome concurrently target multiple mRNAs. Recent evidence has shown miRNAs are involved progression, including promoting cell-cycle, conferring resistance to apoptosis, enhancing invasiveness Here, we aim elucidate roles miRNAs, especially microRNA-4665-3p (miR-4665-3p),...
Metastasis is the major cause of death and failure cancer chemotherapy in patients with breast (BC). Activation TGF-β/lncRNA-MALAT1/miR-200c has been reported to play an essential role during metastasis BC cells. The present study aimed validate suppression BC-cell migration invasion by baicalin explore its regulatory effects on signaling pathway. We found that treatment inhibited cell viability invasion. Mechanistically, significantly downregulated expression TGF-β, ZEB1, N-cadherin...
The eukaryotic chaperonin family is vital for cell survival. dysregulation of chaperonin-containing TCP-1 subunit 3 (CCT3) implicated in several types malignant tumors' development. However, its functional role melanoma remains unknown. Here we elucidate the contribution to CCT3 progression. results indicated that highly expressed tissues, and overexpression correlated with clinical stage patients. Knockdown by shRNA cells inhibited proliferation cycle progression induced apoptosis vitro. In...