A5015669481- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Alzheimer's disease research and treatments
- Organ Transplantation Techniques and Outcomes
- Traditional Chinese Medicine Analysis
- Myasthenia Gravis and Thymoma
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Telomeres, Telomerase, and Senescence
- Cardiac Fibrosis and Remodeling
- Chronic Lymphocytic Leukemia Research
- Peripheral Neuropathies and Disorders
- Congenital heart defects research
- Diabetes and associated disorders
- Cardiac Imaging and Diagnostics
- RNA Interference and Gene Delivery
- Cholinesterase and Neurodegenerative Diseases
- Immunodeficiency and Autoimmune Disorders
- Mesenchymal stem cell research
Hunan Academy of Traditional Chinese Medicine
2019-2025
Hunan University
2023-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2020-2025
Nanjing Sport Institute
2018-2024
Hunan University of Traditional Chinese Medicine
2023-2024
Capital Medical University
2020-2022
Beijing Children’s Hospital
2022
Dalian Medical University
2004-2016
Chongqing Medical University
2004-2016
Second Affiliated Hospital of Chongqing Medical University
2004-2016
Administration of cardiac progenitor cells (CPCs) 4 hours after reperfusion ameliorates left ventricular function in rats with acute myocardial infarction (MI). Clinically, however, this approach is not feasible, because expansion autologous CPCs MI requires several weeks. Therefore, we sought to determine whether are beneficial the more clinically relevant setting an old (scar).One month coronary occlusion/reperfusion, received intracoronary infusion vehicle or enhanced green fluorescent...
purpose. Evidence supports the immune system activity accompanying glaucomatous neurodegeneration. This study aimed to determine in vitro effects of reactive oxygen species (ROS) on phenotype and antigen-presenting function retina optic nerve head glia. methods. Cultures rat glia were treated with a mixture ROS-generating compounds for 24 48 hours. Pretreated glial cells then coincubated syngeneic CD4+ T ROS generation cell viability assessed use dihydroethidium calcein assays, respectively....
The aims of this study were to determine whether IL-17(+) T cells present in CD4 and CD8 interphotoreceptor retinoid-binding protein (IRBP)-specific the role antigen-specific nonspecific pathogenesis experimental autoimmune uveitis (EAU).B6 mice immunized with uveitogenic peptide IRBP1-20. In vivo-primed separated stimulated immunizing peptide. Intracellular expression IFN-gamma IL-17 by was assessed, pathogenic activity activated determined.A subset autoreactive IRBP-specific expressed...
Abstract Background Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced B-cell-dominated diseases that affect neuromuscular junction. Several subtypes of CD4 + T cells, including helper (Th) 17 follicular Th regulatory cells (Tregs), contribute to pathogenesis MG. However, increasing evidence suggests CD8 also play a critical role in treatment Main body Herein, we review literature on MG, focusing their potential effector roles,...
The pathogenesis of Alzheimer's disease (AD), a degenerative the central nervous system, remains unclear. main manifestations AD include cognitive and behavioral disorders, neuropsychiatric symptoms, neuroinflammation, amyloid plaques, neurofibrillary tangles. However, current drugs for once dementia stage has been reached only treat symptoms do not delay progression, research development targeted have bottleneck. Thus, other treatment options are needed. Bioactive ingredients derived from...
ABSTRACT HuangqiGuizhiWuwu decoction (HGWD) possesses a complex and diverse chemical composition, rendering the identification of its components challenging. In this study, UPLC fingerprinting profile HGWD was elucidated method determining multiple in proposed. Common peaks were selected from 12 batches HGWD, Chinese herbal chromatographic fingerprint similarity evaluation system (2012) employed for analyses. The corresponding to common identified using UPLC‐Q‐TOF‐MS. Chemical analyses...
Currently, flow cytometry and immunomagnetic bead purification are the most commonly used cell sorting methods. We performed this study because there few reports that directly compare efficiency influence on functions of these two The in vitro cultured third-generation bone marrow mesenchymal cells from newborn Sprague-Dawley rats were sorted purified using sterile beads to obtain CXCR4-positive stem (CXCR4+-MSCs). yield purity (detected by cytometry), viability MTT method), chemotactic...
Abstract We previously demonstrated that cultures of rat uveitogenic T cells rapidly become dominated by CD4+ cells, but activation CD8+ autoreactive also occurred during the in vitro culture vivo-primed cells. In present study, we show commonly used peptide, interphotoreceptor retinoid-binding protein (IRBP) 1–20, generated both and C57BL/6 (B6) mouse this 20-mer contains at least two distinct antigenic epitopes. To determine whether CD8 response was Ag-specific IRBP1–20-specific recognize...
Results in previous reports have demonstrated that immunization of the EAU-prone B6 mouse activates both CD4 and CD8 IRBP-specific T cells. The purpose this study was to investigate structural functional differences between autoreactive cells activated by uveitogenic peptide.Purified isolated from mice immunized with an peptide, interphotoreceptor retinoid-binding protein (IRBP)1-20, were stimulated vitro various doses immunizing peptide. determined for cytokine production, expression Foxp3,...
Although statins impart a number of cardiovascular benefits, whether statin therapy during the peri-infarct period improves subsequent myocardial structure and function remains unclear. Thus, we evaluated effects atorvastatin on cardiac function, remodeling, fibrosis, apoptosis after infarction (MI). Two groups rats were subjected to permanent coronary occlusion. Group II (n = 14) received oral (10 mg/kg/d) daily for 3 wk before 4 MI, while group I 12) equivalent doses vehicle. Infarct size...
Abstract Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a pathologically similar disease used to model MS in rodents, are typical CD4 + T cell-dominated diseases. interleukin (IL)17 cells (Th17 cells) have been well studied shown that they play critical role the pathogenesis of MS/EAE. However, studies suggested CD8 IL17 (Tc17 phenotype cytokine transcription factor profiles those Th17 found be crucial diseases, including MS/EAE, psoriasis, type I diabetes,...
A telomerase-like primer extension activity has been detected in chromatographic fractions derived from Schizosaccharomyces pombe extracts. This acts preferentially on dG-rich oligodeoxynucleotides, is sensitive to RNase pretreatment and requires all four deoxynucleotides for optimal polymerization. The products are also truncated by the inclusion of any one dideoxynucleotides, consistent with presence bases S.pombe telomeric repeats. intensity distribution dideoxynucleotide termination...