A5045238753- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Antiplatelet Therapy and Cardiovascular Diseases
- Histone Deacetylase Inhibitors Research
- Transplantation: Methods and Outcomes
- Inflammatory mediators and NSAID effects
- Neutropenia and Cancer Infections
- Estrogen and related hormone effects
- Polyomavirus and related diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- NF-κB Signaling Pathways
- Bone and Joint Diseases
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2006-2013
Steroid-resistant (SR) acute graft-versus-host disease (aGVHD) lacks standard second-line treatment. Mesenchymal stromal cells (MSCs) have potential efficacy in SR aGVHD. We aimed to assess the and safety of MSCs combined with basiliximab calcineurin inhibitor as therapy for
Quercetin is one of the naturally occurring dietary flavonol compounds. It present abundantly in plants and has chemopreventive anticancer effects. To investigate its mechanism, we examined activity quercetin against acute leukemia cell line, HL-60. Our results showed that inhibited proliferation induced apoptosis a time- dose-dependent manner. Furthermore, down-regulated expression anti-apoptosis protein Bcl-2 up-regulated pro-apoptosis Bax. Caspase-3 was also activated by quercetin, which...
We conducted a prospective, randomized, open-label, multicenter study to compare busulfan plus fludarabine (BuFlu) with cyclophosphamide (BuCy) as the conditioning regimen in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML) first complete remission (CR1). Totally 108 AML-CR1 patients undergoing allo-HSCT were randomized into BuCy (busulfan 1.6 mg/kg, q12 hours, -7 ~ -4d; 60 mg/kg.d, -3 -2d) or BuFlu -5 -2d; 30 mg/m2.d, -6 group. Hematopoietic...
Compared with HLA-matched sibling donor (MSD) transplant, the outcomes of haploidentical (HID) transplant for refractory acute leukemia need to be further explored. In this study, we compared HID MSD leukemia.This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Two hundred and seventy-eight patients were enrolled in including 119 group 132 group. Sequential intensified conditioning was employed all patients, lymphocyte infusion (DLI) administered...
Objective: To analyze the relationship between platelet parameters and bacterial types in patients with bacteremia. Methodology: Data from 265 positive blood cultures were collected. Clinical procalcitonin (PCT) recorded. Results: In bacteremia, gram-negative (G-) bacteria accounted for 56% of cases, gram-positive (G +) 44% cases. white cell counts (WBC), neutrophil (NEUT), percentage neutrophils (NEUT%), PCT increased, lymphocyte (LYM) lymphocytes (LYM%) decreased. The differences...
Purpose: Quiescent leukemia stem cells (LSC) are important resources of resistance and relapse in chronic myelogenous (CML). Thus, strategies eradicating CML LSCs required for cure. In this study, we discovered that AXL tyrosine kinase was selectively overexpressed primary CD34+ cells. However, the role its ligand Gas6 secreted by stromal regulation self-renewal capacity has not been well investigated.Experimental Design: The function evaluated flow cytometer, CFC/replating, long-term...
Acute myeloid leukemia (AML) is one of the most common malignancies hematopoietic progenitor cell in adults. Quercetin has gained recognition over years because its anti-cancer effect with minimal toxicity. Herein, we aim to investigate anti-leukemia mechanism quercetin and decipher signaling pathway HL-60 leukemic cells. We observed that induces apoptosis autophagic death, which both pathways play an important role suppressing viability Phosphorylated AMPK (p-AMPK) protein expressions are...
Imatinib revolutionized the treatment of chronic myeloid leukemia (CML), but drug resistance and disease recurrence remain a challenge. In this study, we suggest novel strategy based on blocking protein neddylation to address BCR-ABL point mutations stem cells (LSC) that lie at root imatinib-resistant recurrences. On basis finding NEDD8-activating enzyme subunit NAE1 is overexpressed in CML cells, hypothesized function certain neddylation-dependent substrates might be targeted therapeutic...
// Li Xuan 1 , Zhiping Fan Yu Zhang Hongsheng Zhou Fen Huang Min Dai Danian Nie 2 Dongjun Lin 3 Na Xu Xutao Guo Qianli Jiang Jing Sun Yang Xiao 4 Qifa Liu Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Yat-Sen Memorial 510120, the Third Affiliated 510630, General Hospital Military Command, 510010, Correspondence to: Liu, email: liuqifa628@163.com Keywords: donor lymphocyte infusion, refractory advanced acute leukemia, relapse, allogeneic...
Haploidentical donor (HID) allogeneic hematopoietic stem cell transplantation (HSCT) is an alternative curative treatment for patients with severe aplastic anemia (SAA) who do not have suitable matched related donors (MRD). The aim of this study was to compare the therapeutic outcomes HID-HSCT those MRD-HSCT SAA.A total 235 SAA underwent (116) or (119) at 11 centers from January 2007 2016 were included. Complications and survival evaluated compared between 2 groups.The HID group had a lower...
Purpose: Leukemia stem cells (LSCs) are an important source of tyrosine kinase inhibitor resistance and disease relapse in patients with chronic myelogenous leukemia (CML). Targeting LSCs may be attractive strategy to override this thorny problem. Given that EZH2 was overexpressed primary CML CD34+ cells, our purpose study evaluate the effects targeting on clarify its underlying mechanism.Experimental Design: Human retrovirally BCR-ABL-driven mouse models were employed suppression by GSK126-...
BackgroundBronchiolitis obliterans syndrome (BOS) after allo-HSCT is a devastating complication with limited therapeutic options. We aimed to assess the efficacy and safety of mesenchymal stem cells (MSCs) in BOS allo-HSCT.MethodsThis multicenter prospective cohort study enrolled 81 recipients whose were diagnosed within 6 months. The choice prednisone azithromycin combined or without MSCs was based on patient preferences (MSC n = 49, non-MSC 32). primary endpoint response rate at 3 months,...
Leukemia stem cells are dependent on the super-enhancer–associated oncogene XBP1, suggesting a potential targeting strategy in relapsed CML.
Resistance to chemotherapy is still a challenge for the treatment of acute myeloid leukemia. Combination use histone deacetylase inhibitors (HDACIs) and proteasome may provide potential way overcome drug resistance. One HDACIs, valproic acid (VPA), inhibitor, bortezomib (BOR), were assessed. Co-exposure cells VPA BOR inhibited proliferation, arrested cell cycle in G0-G1 phase induced apoptosis both HL60 HL60A cells. These events accompanied by inhibition cyclin D1 human telomerase reverse...
We conducted a phase II, noncomparative, multicenter study to assess the efficacy and safety of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) expanded in vitro for patients with aplastic anemia (AA) refractory immunosuppressive therapy. Seventy-four from seven centers received BM-MSCs at dose 1-2 × 106 cells/kg per week 4 weeks. Responses were assessed 0.5, 1, 2, 3, 6, 9, 12 months after first infusion. Patients response 1 month continued receive four infusions. All...
We performed a prospective study to evaluate the efficacy and safety of secondary antifungal prophylaxis (SAP) for patients with history invasive pulmonary aspergillosis (IPA) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this study, prophylactic agents used were chosen based on treatment response initial therapy. One hundred thirty-six undergoing allo-HSCT prior IPA enrolled multicenter study. The SAP included itraconazole 24, voriconazole 74, caspofungin 32,...