A5029779558- Hematopoietic Stem Cell Transplantation
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Genetics, Bioinformatics, and Biomedical Research
- Gene expression and cancer classification
- Mesenchymal stem cell research
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Periodontal Regeneration and Treatments
- Immune Response and Inflammation
- AI in cancer detection
- Bone and Joint Diseases
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- Immune cells in cancer
- Proteoglycans and glycosaminoglycans research
- Menopause: Health Impacts and Treatments
- Flavonoids in Medical Research
- Cardiac Ischemia and Reperfusion
- Angiogenesis and VEGF in Cancer
- Estrogen and related hormone effects
Third Affiliated Hospital of Guangzhou Medical University
2015-2025
Obstetrics and Gynecology Hospital of Fudan University
2018-2025
Guangzhou Medical University
2015-2025
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Fuzhou Maternity and Child Health Care Hospital
2019-2022
ABSTRACT Objective To determine the optimal luteinising hormone (LH) level on trigger day and its impact pregnancy outcomes in gonadotropin‐releasing (GnRH) antagonist protocols using a data‐driven approach. Design Retrospective cohort study. Setting Third Affiliated Hospital of Guangzhou Medical University. Population Overall, 6107 vitro fertilisation/intra‐cytoplasmic sperm injection fresh embryo transfer cycles with GnRH‐antagonist were performed between January 1, 2018 February 2023....
ABSTRACT Objective To clarify the protective effects of gonadotropin‐releasing hormone analogues (GnRHas) on cyclophosphamide (CTX)‐induced oocyte number loss and development potential damage. Design Mice model study. Setting Laboratory‐based animal study conducted in controlled research facilities. Population Female C57/BL6 mice subjected to CTX‐induced ovarian Methods The GnRHa CTX were evaluated terms hormones, count slices, established three‐dimensional–constructed ovaries, vitro...
Abstract Peritoneal metastasis is a common issue in the progression of high-grade serous ovarian cancers (HGSOCs), yet underlying mechanism remains unconfirmed. We demonstrated that ZEB2, transcription factor epithelial–mesenchymal transition (EMT), was upregulated ascites cells from HGSOC patients and CD133 + cancer stem-like (CSLCs) epithelial (EOC) cell lines. SiRNA-mediated knockdown ZEB2 EOC decreased percentage CSLCs reduced colony forming potential, invasion capacity expression...
Ovarian cancer (OV) is regarded as one of the most lethal malignancies affecting female reproductive system, with individuals diagnosed OV often facing a dismal prognosis due to resistance chemotherapy and presence an immunosuppressive environment. T cells serve crucial mediator for immune surveillance elimination. This study aims analyze mechanism cell-associated markers in create prognostic model clinical use enhancing outcomes patients.
Metastasis is the major cause of death and failure cancer chemotherapy in patients with breast (BC). Activation TGF-β/lncRNA-MALAT1/miR-200c has been reported to play an essential role during metastasis BC cells. The present study aimed validate suppression BC-cell migration invasion by baicalin explore its regulatory effects on signaling pathway. We found that treatment inhibited cell viability invasion. Mechanistically, significantly downregulated expression TGF-β, ZEB1, N-cadherin...
Ovarian cancer (OC) is one of the leading lethal gynecologic cancers women around world. More than 70% patients are diagnosed with stage III or IV poor outcome. This partly because lacking early effective screening techniques and potential biomarkers OC. CXC chemokines in tumor microenvironment (TME) their interaction relative receptors can excite downstream signaling pathways to influence progression. However, role OC has not been identified.ONCOMINE, GEPIA, Kaplan-Meier plotter,...
Abstract Aplastic anemia (AA) is a blood disorder resulted from over-activated T-cell related hematopoietic failure, with the characterization of hypocellularity and enhanced adipogenic differentiation mesenchymal stroma cells (MSCs) in bone marrow (BM). However, little known about relationship between immune imbalance polarized abnormity BM microenvironment this disease entity. In present study, we differentiated BM-MSCs into osteoblastic or lineages to mimic osteo-adipogenic...
The generation of hematopoietic stem cells (HSCs) and blood from human embryonic (hESCs) is a major goal for regenerative medicine; however, the differentiation mechanisms are largely undefined. Here, we aimed to identify regulated genes functional modules related early endothelial-to-hematopoietic transition (EHT) using comprehensive bioinformatics analyses. Undifferentiated hESCs (hESC-H9), CD34+ 10-day differentiated hESC-H9 cells, umbilical cord were isolated collected. Cells these three...
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Abstract STUDY QUESTION Does vitrification cryopreservation of embryos for more than 5 years affect the pregnancy outcomes after frozen embryo transfer (FET)? SUMMARY ANSWER Vitrification good-quality blastocysts is associated with a decrease in implantation rate (IR) and live birth (LBR). WHAT IS KNOWN ALREADY Previous studies have predominantly focused on cryopreserved relatively short durations (less years), yet impact extended duration remains controversial issue. There relative scarcity...
Can a simplified ovarian hyperstimulation syndrome (OHSS) risk assessment index be developed and validated with sufficient discrimination of moderate/severe OHSS from those without OHSS?
Objective In the present study, we investigated effects of advanced oxidation protein products(AOPP) on reactive oxygen species(ROS) production in murine osteoblastic MC3T3-E1 cells by NADPH oxidase enzymes pathway. Methods Experiments were divided into three groups, including control group, rats albumin(RSA) and AOPP group. Different concentrations added to culture medium. The ROS was measured fluorescence intensity intracellular fluoroprobe(DCFD). In order verify effect enzyme ROS,...
Objective To investigate the feasibility of human umbilical vein endothelial cells (hUVECs) and bone marrow mesenchymal stem (BMSCs) forming vascular network like structure in three-dimensional co-cultured system. Methods Green fluorescent protein red to were used transfect 4th generation respectively, which implanted into typeⅠ rat tail collagen co-culture dish including a volume fraction 5% extracellular matrix (ECM) fatal bovine serun (FBS) medium 1 ml. Through confocal laser...
Objective: Cyclophosphamide (CTX), which is commonly used in clinical chemotherapy, has a damaging effect on ovarian follicles. This study aimed to establish new method count the number of follicles mouse ovaries using benzyl alcohol-benzyl benzoate (BABB)-based tissue-clearing technology and evaluate follicle-damaging effects different doses CTX. Methods: C57BL/6 mice were divided into four groups administered intraperitoneal injections 0, 40, 80, or 120 mg/kg The serum levels estradiol...
Abstract Purpose The mechanism of lymph node metastasis (LNM) cervical squamous cell carcinoma (CSCC) remains unconfirmed. Here we investigate the effects and mechanisms midkine (MDK) on CSCC LNM. Methods expression MDK in normal tissue was analyzed. In vivo vitro experiments explored A retrospective study 134 53 healthy controls relationship serum-MDK(s-MDK) clinicopathological characteristics performed to evaluate clinical value s-MDK Results highly expressed overexpression associated with...