A5041699764- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Ovarian function and disorders
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Renal and related cancers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Assisted Reproductive Technology and Twin Pregnancy
- Circadian rhythm and melatonin
- CRISPR and Genetic Engineering
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Geophysical Methods and Applications
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Seed Germination and Physiology
- Seismic Waves and Analysis
- Effects and risks of endocrine disrupting chemicals
- Geophysical and Geoelectrical Methods
Third Affiliated Hospital of Guangzhou Medical University
2015-2025
Guangzhou Medical University
2015-2025
East China Mineral Exploration & Development Bureau
2023
Sun Yat-sen University
2014-2015
The First Affiliated Hospital, Sun Yat-sen University
2015
Actl6a (actin-like protein 6A, also known as Baf53a or Arp4) is a subunit shared by multiple complexes including esBAF, INO80, and Tip60-p400, whose main components (Brg1, Ino80, p400, respectively) are crucial for the maintenance of embryonic stem cells (ESCs). However, whether how functions in ESCs has not been investigated. originate from epiblast (EPI) that derived inner cell mass (ICM) blastocysts, which give rise to primitive endoderm (PrE). The molecular mechanisms EPI/PrE...
Benzo(a)pyrene (BaP) was detected in human follicular fluid at concentrations of approximately 5 nM smokers and 7 cases assisted reproductive failure. However, whether low concentration BaP affects germinal vesicle (GV) oocyte maturation remains unclear. Here, we investigated the effects on GV both mice humans. In mice, oocytes were treated with or 50 BaP, while exposed to BaP. Our results demonstrated that exposure significantly inhibited first polar body extrusion during maturation....
Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It hard to uncover the real function testis specific gene in vitro since model not yet mature. With development CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9) system, we can now rapidly generate knockout mouse models genes study vivo. SYCP3-like X-linked 2 (SLX2) germ cell component, which contains Cor1 domain and belongs XLR (X-linked, lymphocyte regulated)...
Abstract STUDY QUESTION Is there a difference in the cumulative live birth rate (CLBR) after fresh testicular sperm aspiration (TESA) compared with use of either pre-frozen or oocyte freezing for couples experiencing ejaculation failure on day retrieval? SUMMARY ANSWER After adjusting confounding factors, and thawing oocytes appeared to be as effective TESA achieving CLBRs temporary failure. WHAT IS KNOWN ALREADY Male patients may concerned about their partner’s retrieval, which case they...
Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive researches, how internal external factors affecting hatch are still largely unclear.The effects parental genetic material oxygen concentration on were examined. Fertilized parthenogenetic mouse preimplantation embryos cultured in vitro under 5 20% 120 h. Zona pellucida drilling by Peizo...
Abstract STUDY QUESTION Does vitrification cryopreservation of embryos for more than 5 years affect the pregnancy outcomes after frozen embryo transfer (FET)? SUMMARY ANSWER Vitrification good-quality blastocysts is associated with a decrease in implantation rate (IR) and live birth (LBR). WHAT IS KNOWN ALREADY Previous studies have predominantly focused on cryopreserved relatively short durations (less years), yet impact extended duration remains controversial issue. There relative scarcity...
Abstract Background Approximately 5 nM -7 internal exposure concentration of BaP was detected in women who mainstream smoke or suffering assisted reproductive failure. In this study, we evaluated the effects benzo(a)pyrene (BaP) on mouse and human germinal vesicle (GV) oocyte maturation BaP. Then, tested whether nicotinic acid (NA) could restore GV meiotic failure caused by not during vitro (IVM)? Methods Clinically discarded oocytes from young (aged < 35 years) undergoing...
Abstract Accumulating evidence has demonstrated that high concentration of benzo(a)pyrene (BaP) causes oocyte and embryo developmental arrest or death resulting in early pregnancy loss. However, whether the physiological BaP exposure affects GV maturation population remains unclear. Here, we evaluate effects human ovarian follicular fluid concentrations on mouse germinal vesicle (GV) maturation. Moreover, examined nicotinic acid (NA) reversed meiotic failure caused by during vitro (IVM). We...
Abstract Background: Evaluating the efficacy and safety of ovarian stimulation protocols is beneficial for infertile patients undergoing in vitro fertilization (IVF). The mild stimulation-IVF (m-IVF) protocol using clomiphene citrate considered to have better neonatal outcomes fresh cycles; however, few studies evaluated frozen-thawed embryo transfer (FET) cycles. Therefore, we aimed compare risks following (ET) FET between m-IVF conventional IVF protocols. Methods: baseline characteristics,...
Endometriosis (EM) affects 10% women of reproductive age and alters fertility. Its management is still debated notably the timing surgery ART in infertility. Kallistatin (KS) an endogenous protein that regulates differential signaling pathways biological functions. However, function underlying molecular mechanism EM its correlation with vitro fertilization (IVF) outcome have not been determined. The purpose this study was to evaluate KS concentrations follicular fluid (FF) controls without...
Abstract Background It was known that in patients with good prognosis, day 5 good-quality blastocysts formed by available cleavage embryos (AEs) or poor-quality (PQEs) did not affect clinical outcomes. However, the outcomes of 5/6 expanded cultured who faced PQEs unclear. Methods Retrospective cohort study conducted among women aged ≤ 38 underwent vitrified-warmed single blastocyst transfers (SBTs) which originated from AEs (n = 382), 99), only without 101). Results The compared to showed...
Abstract Background: Endometriosis (EM) affects 10% of women in reproductive age and alters fertility. Its management is still debated notably the timing surgery ART infertility. Kallistatin (KS) an endogenous protein that regulates differential signaling pathways biological functions. However, function underlying molecular mechanism endometriosis its correlation with IVF outcome have not been determined. The purpose this study was to evaluate KS concentrations follicular fluid EM controls...