A5100318868- Protein Tyrosine Phosphatases
- Algal biology and biofuel production
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Catalytic C–H Functionalization Methods
- Microbial Community Ecology and Physiology
- Synthesis and biological activity
- Seaweed-derived Bioactive Compounds
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Bioactive Compounds and Antitumor Agents
- Edible Oils Quality and Analysis
- Receptor Mechanisms and Signaling
- Advanced biosensing and bioanalysis techniques
- Marine and coastal ecosystems
- Angiogenesis and VEGF in Cancer
- Radical Photochemical Reactions
- Carbohydrate Chemistry and Synthesis
- Phytoestrogen effects and research
- Free Radicals and Antioxidants
- Cell Adhesion Molecules Research
- Soybean genetics and cultivation
- Cancer Mechanisms and Therapy
Jiangnan University
2022-2025
Guangdong Ocean University
2025
Chinese Academy of Sciences
2015-2024
Institute of Oceanology
2015-2024
Tianjin Fourth Central Hospital
2024
Tianjin Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Northwest A&F University
2024
Southern Medical University
2024
Nanjing University
2024
In recent years, liquid–solid triboelectric nanogenerators (L-S TENGs) have been rapidly developed in the field of liquid energy harvesting and self-powered sensing. This is due to a number advantages inherent technology, including low cost fabricated materials, structural diversity, high charge-energy conversion efficiency, environmental friendliness, wide range applications. As phase dielectric materials typically used L-S TENG, variety organic inorganic single-phase liquids, distilled...
This report describes the synthesis of two cyclic RGD (Arg-Gly-Asp) conjugates, HYNIC-2PEG4-dimer (HYNIC = 6-hydrazinonicotinyl; 2PEG4-dimer E[PEG4-c(RGDfK)]2; and PEG4 15-amino-4,7,10,13-tetraoxapentadecanoic acid) HYNIC-3PEG4-dimer (3PEG4-dimer PEG4-E[PEG4-c(RGDfK)]2), evaluation their 99mTc complexes [99mTc(HYNIC-2PEG4-dimer)(tricine)(TPPTS)] (99mTc-2PEG4-dimer: TPPTS trisodium triphenylphosphine-3,3′,3′′-trisulfonate) [99mTc(HYNIC-3PEG4-dimer)(tricine)(TPPTS)] (99mTc-3PEG4-dimer) as...
Cardiac fibrosis is the pathological consequence of fibroblast proliferation and fibroblast-to-myofibroblast transition. As a new class endogenous noncoding RNAs, circular RNAs (circRNAs) have been identified in many cardiovascular diseases including fibrosis, generally acting as microRNA (miRNA) sponges. Here, we report that expression circRNA-circNFIB was decreased mice post-myocardial infarction heart samples, well primary adult cardiac fibroblasts treated by TGF-β. Forced circNFIB cell...
Exercise training benefits the heart. The knowledge of post-transcription regulation, especially RNA editing, in hearts remain rare. ADAR2 is an enzyme that edits adenosine to inosine nucleotides double-stranded RNA, and editing associated with many human diseases. We found was upregulated during exercise training. AAV9-mediated cardiac-specific overexpression attenuated acute myocardial infarction (AMI), MI remodeling, doxorubicin (DOX)-induced cardiotoxicity. In vitro, inhibited...
Cardiac death is a major burden for cancer survivors, yet there currently no effective treatment doxorubicin (DOX)-induced cardiotoxicity. Here, we report that circ-ZNF609 knockdown had cardioprotective effects against DOX-induced cardiomyocyte toxicity. Mechanistically, alleviated cardiotoxicity through attenuating apoptosis, reducing reactive oxygen species production, ameliorating mitochondrial nonheme iron overload. inhibition blocked the elevation of RNA N6-methyladenosine (RNA m6A)...
Current understanding of cytoplasmic signaling pathways that mediate estrogen action in human breast cancer is incomplete. Here we report treatment with 17beta-estradiol (E2) activates a novel pathway via activation sphingosine kinase (SphK) MCF-7 cells. We found E2 has dual actions to stimulate SphK activity, i.e. rapid and transient mediated by putative membrane G protein-coupled receptors (ER) delayed but prolonged relying on the transcriptional activity ER. The E2-induced consequently...
The Gq protein-coupled receptor agonists phenylephrine (PE) and endothelin-1 (ET-1) induce cardiac hypertrophy stimulate protein synthesis in cardiomyocytes. This study aims to investigate how they activate mRNA translation adult PE ET-1 do not kinase B but Ras Erk, their ability was blocked by inhibition of or MEK rapamycin, which inhibits mTOR (mammalian target rapamycin). These activated ribosomal S6 1 (S6K1) induced phosphorylation eIF4E-binding protein-1 (4E-BP1) its release from eIF4E....
FTY720, a sphingosine analog, is novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment various autoimmune diseases. Recent studies indicate an additional cytotoxic effect FTY720 its preclinical efficacy in variety cancer models, yet underlying mechanisms remain unclear. We demonstrate here first time that exhibits potent, dose- time-dependent human ovarian cells, even cells are resistant to cisplatin, commonly...
Natural products offered more opportunities to develop new drugs and leading compounds as potent PTP1B inhibitors for treating T2DM.
Poly(ADP-ribose) polymerase-1 (PARP-1) is a new potential target for anticancer drug discovery. A series of bromophenol–thiosemicarbazone hybrids as PARP-1 inhibitors were designed, synthesized, and evaluated their antitumor activities. Among them, the most promising compound, 11, showed excellent selective inhibitory activity (IC50 = 29.5 nM) over PARP-2 > 1000 potent activities toward SK-OV-3, Bel-7402 HepG2 cancer cell lines 2.39, 5.45, 4.60 μM), along with inhibition tumor growth in an...
Circular RNAs take crucial roles in several pathophysiological processes. The regulatory role and its underlying mechanisms of circ-ZNF609 the heart remains largely unknown. Here, we report that is upregulated during myocardial ischemia/reperfusion (I/R) remodeling. Knockdown protects against acute I/R injury attenuates left ventricle dysfunction after remodeling vivo. In vitro, regulates cardiomyocyte survival proliferation via modulating crosstalk between Hippo-YAP Akt signaling....
Insulin acutely activates protein synthesis in ventricular cardiomyocytes from adult rats. In this study, we have established the methodology for studying regulation of signaling pathways and translation factors that may be involved response examined effects acute insulin treatment on them. rapidly activated 70-kDa ribosomal S6 kinase (p70 S6k), effect was inhibited both by rapamycin inhibitors phosphatidylinositol 3-kinase. The activation p70 S6k is mediated a pathway involving mammalian...
Bromophenol is a type of natural marine product. It has excellent biological activities, especially anticancer activities. In our study searching for potent drugs, novel bromophenol derivative containing indolin-2-one moiety, 3-(4-(3-([1,4'-bipiperidin]-1'-yl)propoxy)-3-bromo-5-methoxybenzylidene)-N-(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-102) was synthesized, which showed activities on human lung cancer cell lines. A the mechanisms indicated that BOS-102 could significantly block...