A5040987305- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Molecular Sensors and Ion Detection
- Berberine and alkaloids research
- HER2/EGFR in Cancer Research
- Liver physiology and pathology
- Sulfur Compounds in Biology
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Sirtuins and Resveratrol in Medicine
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Bioactive natural compounds
- Autophagy in Disease and Therapy
- Histiocytic Disorders and Treatments
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Ferroptosis and cancer prognosis
- Folate and B Vitamins Research
Shandong University of Science and Technology
2024
Xinxiang Medical University
2014-2024
Fudan University
2023-2024
Jiangsu Province Hospital
2015-2024
Nanjing University of Chinese Medicine
2015-2024
Zhengzhou University
2010-2024
Materials Science & Engineering
2024
Huashan Hospital
2024
Central South University
2020-2022
Xiangya Hospital Central South University
2020-2022
Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential mechanisms require further exploration. We aimed to reveal HSYA against acute TBI by an integrated strategy combining metabolomics with network pharmacology. controlled cortical impact (CCI) rat model was established, neurological functions were evaluated. Metabolomics tissues used identify differential...
Bleeding and bacterial infections are crucial factors affecting wound healing. The usage of herbal medicine-derived materials holds great potential for promoting However, the uncertain intrinsic effective ingredients unclear mechanism action remain concerns. Herein, inspired by medicine Ligusticum wallichii, we reported synthesis tetramethylpyrazine-derived carbon quantum dots (TMP-CQDs) Of note, use TMP as precursor instead L. wallichii ensured repeatability homogeneity obtained products....
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most common AIDS-related malignancy. KS characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation accelerate Kaposin A-induced tumorigenesis. Here, we explored promotion of vIL-6-induced promotes cell proliferation, cellular transformation, vascular tube formation VEGF production in culture. enhances tumorigenesis...
Abstract Kaposi's sarcoma (KS) is an AIDS-defining cancer with aberrant neovascularization caused by KS-associated herpesvirus (KSHV). Although the interaction between HIV-1 and KSHV plays a pivotal role in promoting aggressive manifestations of KS, pathogenesis underlying AIDS-KS remains largely unknown. Here we examined Nef protein promotion oncoprotein K1-induced angiogenesis. We showed that both internalized ectopic expression endothelial cells synergized K1 to facilitate vascular tube...
Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, exact molecular function UBE2C in breast carcinoma (BRCA) remained elusive. We aimed investigate expression BRCA and its clinical significance.The 209 tissue samples 53 adjacent normal was detected using immunohistochemistry. The role analyzed. Public databases including protein atlas Oncomine were used assess BRCA. Moreover, cancer genome...
Co-infection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause of aggressive AIDS-related sarcoma (AIDS-KS) characterized by abnormal angiogenesis. The impact KSHV interaction on pathogenesis extensive angiogenesis AIDS-KS remains unclear. Here, we explored synergistic effect Tat oncogene Orf-K1 Our results showed that soluble or ectopic expression enhanced K1-induced cell proliferation, microtubule formation in chorioallantoic membrane nude mice models. Mechanistic...
Cisplatin treatment some times leads to chemoresistance, which is now acknowledged partially due the inductive expression of progesterone receptor membrane component (PGRMC)1 in ovarian cancer cells. PGRMC1 enhances autophagy, activates cytochrome p450, and inveigles signaling pathways promote cell survival reduce effect drug treatments. In this study, we give first line evidence that hyperoside inhibits viability, triggers autophagy apoptosis lines. Mechanistically, PGRMC1-dependent was...
Hedysarum multijugum Maxim.-Chuanxiong rhizoma compound (HCC) is a common herbal formula modified from Buyang Huanwu decoction. Clinical trials have demonstrated its therapeutic potential for ischemic stroke (IS). However, the mechanism of HCC remains unclear. The HCC's components were collected TCMSP database and TCM@Taiwan database. After that, targets predicted by PharmMapper. IS-related genes obtained GeneCards, OMIM protein-protein interaction (PPI) data IS String DAVID platform was...
Berberine (BBR) has been suggested to be a hepatoprotective agent for oxidative‐stress‐related liver diseases because of its antioxidant activity. However, the mechanisms BBR are still not fully understood. In present study, protective effect was evaluated, and underlying molecular were investigated in hepatic cell line L02. Results from viability apoptosis assay showed that cells exposed hydrogen peroxide (H 2 O ), pretreatment 12 μM could increase by 19.10 ± 7.40% reduce apoptotic 7.91...
Many reports suggest that the discovery of microRNAs (miRNAs) might provide a novel therapeutical target for many diseases, even human cancers; however, there are no on role miR-597 in cancers. In present study, by detecting mRNA expression with qRT-PCR, compared adjacent normal tissues we found was significantly downregulated breast cancer tissues. By using MTT assay, cell wound-healing assay and invasion demonstrated mimics were able to suppress proliferation, migration invasion....
The cooverexpression of epidermal growth factor receptor (EGFR) and human 2 (HER2) observed in many tumors their synergistic interaction the transformation cells make these receptors important targets for development new targeted therapeutics. Targeting EGFR HER2 simultaneously has been pursued as a strategy with which to potentially increase efficiency selectivity therapy certain cancers. This study was set construct bispecific energized fusion protein (Ec-LDP-Hr-AE) consisting two...
The natural compound berberine has been reported to exhibit anti-diabetic activity and improve disordered lipid metabolism. In our previous study, we found that such compounds upregulate expression of sirtuin 1—a key molecule in caloric restriction, it is, therefore, great interest examine the lipid-lowering combination with a 1 activator resveratrol. Our results showed resveratrol had enhanced hypolipidemic effects high fat diet-induced mice was able decrease accumulation adipocytes level...
Abstract Background Tumor-associated macrophages (TAMs) significantly influence the progression, metastasis, and recurrence of esophageal squamous cell carcinoma (ESCC). The aberrant expression long noncoding RNAs (lncRNAs) in ESCC has been established, yet role lncRNAs TAM reprogramming during progression remains largely unexplored. Methods TAM-related were identified by intersecting differentially expressed with immune-related performing immune infiltration analysis. profile clinical...
With a long history of application in Chinese traditional medicine, berberine (BBR) was reported to exhibit healthspan-extending properties some age-related diseases, such as type 2 diabetes and atherosclerosis. However, the antiaging mechanism BBR is not completely clear. By means hydrogen peroxide- (H2O2-) induced premature cellular senescence model, we found that low-concentration preconditioning could resist human diploid fibroblasts (HDFs) measured by senescence-associated...
A two-photon fluorescent probe <bold>NPClA</bold> was developed for imaging mitochondrial stress.
Abstract Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs NAD + -dependent deacetylases has established diverse roles in aging, metabolism disease. Here, we report that IEC Sirt6 deletion leads impaired tuft development type 2 immunity infection, thereby resulting compromised worm expulsion. Conversely, after transgenic mice exhibit enhanced remodeling process more efficient clearance....