A5056276396- Aquaculture disease management and microbiota
- interferon and immune responses
- Invertebrate Immune Response Mechanisms
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Animal Genetics and Reproduction
- Physiological and biochemical adaptations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- RNA modifications and cancer
- Extracellular vesicles in disease
- Plant and fungal interactions
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Redox biology and oxidative stress
- Immune cells in cancer
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Study of Mite Species
- Invertebrate Taxonomy and Ecology
- Natural product bioactivities and synthesis
Institute of Hydrobiology
2014-2024
Chinese Academy of Sciences
2014-2024
Hefei University of Technology
2024
Jinan Central Hospital
2024
Shandong First Medical University
2023-2024
Guangxi Medical University
2022-2024
North Sichuan Medical University
2020-2024
Shanghai Jiao Tong University
2024
Ministry of Agriculture and Rural Affairs
2022-2023
Lanzhou University
2021-2023
Bin Han and colleagues report the draft genome sequence of grass carp Ctenopharyngodon idellus, a major commercially farmed species freshwater fish. Analyses identify lineage-specific duplications that may have contributed to adaptation this vegetarian diet. The is an important fish, accounting for ∼16% global aquaculture, has Here we 0.9-Gb gynogenetic female adult 1.07-Gb wild male adult. Genome annotation identified 27,263 protein-coding gene models in genome. A total 114 scaffolds...
Many studies have investigated patterns in the near-surface soil microbial community over large spatial scales. However, less is known about variation subsurface (15-30 cm of depth) communities. Here we studied depth profiles communities high-elevation soils from Tibet. The relative abundance Acidobacteria, Chloroflexi and Alphaproteobacteria was higher layers, while Actinobacteria, Gemmatimonadetes Betaproteobacteria samples. structure distinct between surface strongly correlating with...
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine for intestinal disorders; however, their impact on barrier integrity in gut inflammation and associated metabolic diseases has not explored yet. Here, mEVs derived from bovine human breast milk exert similar protective effects epithelial tight junction functionality vitro, survive harsh gastrointestinal conditions ex vivo, reach the colon vivo. Oral administration of restores at multiple levels,...
Abstract Background Grass carp ( Ctenopharyngodon idella ) is one of the most economically important freshwater fish, but its production often affected by diseases that cause serious economic losses. To date, no good breeding varieties have been obtained using oriented cultivation technique. The ability to identify disease resistance genes in grass cultivate disease-resistant carp. Results In this study, we constructed a non-normalized cDNA library head kidney carp, and, after clustering and...
Grass carp is an important farmed fish in China that affected by serious disease, especially hemorrhagic disease caused grass reovirus (GCRV). The mechanism underlying the symptoms infected remains to be elucidated. Although GCRV can divided into three distinct subtypes, differences pathogenesis and host immune responses different subtypes are still unclear. aim of this study was provide a comprehensive insight response elucidate symptoms. Following infection carp, GCRV-I associated with...
Abstract High-throughput sequencing reveals the complex landscape of small noncoding RNAs (sRNAs). However, it is limited by requiring 5′-monophosphate and 3′-hydroxyl in for adapter ligation hindered methylated nucleosides that interfere with reverse transcription. Here we develop Cap-Clip acid pyrophosphatase (Cap-Clip), T4 polynucleotide kinase (PNK) AlkB/AlkB(D135S)-facilitated ncRNA (CPA-seq) to detect quantify sRNAs terminus multiplicities nucleoside methylations. CPA-seq identified a...
Background: In recent years, the widespread use of lipid-lowering drugs, especially statins, has attracted people’s attention. Statin may be potentially associated with a reduced risk breast cancer. Objective: To explore relationship between statin and cancer risk. And further potential role statins in adjuvant treatment Methods: Data for Mendelian randomization portion study were obtained from genome-wide association studies common cancers UK Biobank FinnGen Global Lipid Genetics...
From the dried roots of Euphorbia fischeriana, seven new diterpenoids, 3alpha,17-dihydroxy-ent-pimara-8(14),15-diene (1), 7beta,11beta,12beta-trihydroxy-ent-abieta-8(14),13(15)-dien-16,12-olide (2), 17-acetoxyjolkinolide B (3), 13beta-hydroxy-ent-abiet-8(14)-en-7-one (4), 12-deoxyphorbaldehyde-13-acetate (5) 12-deoxyphorbaldehyde-13-hexadecacetate (6), and 12-deoxyphorbol-13-(9Z)-octadecanoate-20-acetate (7), two known compounds, 12-deoxyphorbol-13-decanoate (8) prostratin (9), were...
All cultivated ammonia-oxidizing archaea (AOA) within the Nitrososphaera cluster (former soil group 1.1b) are neutrophilic. Molecular surveys also indicate existence of Nitrososphaera-like phylotypes in acidic soil, but their ecological roles poorly understood. In this study, we present molecular evidence for chemolithoautotrophic growth AOA an with pH 4.92 using DNA-based stable isotope probing (SIP). Soil microcosm incubations demonstrated that nitrification was stimulated by urea...
We described a next generation sequencing (NGS)-based approach to identify sex-specific markers and subsequently determine whether species has male or female heterogamety. To test the accuracy of this technique, we examined snakehead (Channa argus), which is economically important freshwater fish in China. Males grow faster than females, there significant interest developing methods skew breeding towards all-males increase biomass yields. NGS was conducted on DNAs individual male, reads were...
Grass carp hemorrhagic disease, caused by the grass reovirus (GCRV), is a major disease that hampers development of aquaculture in China. The mechanism underlying GCRV infection still largely unknown. Circular RNAs (circRNAs) are important regulators involved various biological processes. In present study, were infected with GCRV, and spleen samples collected at 0 (control), 1, 3, 5, 7 days post-infection (dpi). Samples used to construct sequence circRNA libraries, total 5052 circRNAs...
Qingzhuan tea (QZT), as a kind of representative dark tea, is daily necessity for people in the high-cold and high-fat diet areas northwest China, having many health effects such weight loss, lipid reduction, antioxidant ability. The production QZT has history more than 1000 years, which originated Yangloudong, Chibi City, Hubei Province. typically produced by subjecting sun-dried raw green to various processes, including pile fermentation, drying, autoclave formation, aging....
Autophagy is an essential and highly conserved process in mammals, which critical to maintaining physiological homeostasis, including cell growth, development, repair, survival. However, the understanding of autophagy fish virus replication limited. In this study, we found that grass carp reovirus (GCRV) infection stimulated spleen (Ctenopharyngodon idella). Moreover, both Western blot (WB) analysis fluorescent tracer tests showed GCRV induced enhancement activation Ctenopharyngodon idella...
Grass carp is an important aquaculture fish species in China that affected by severe diseases, especially haemorrhagic disease caused grass reovirus (GCRV). However, the mechanisms of GCRV invasion and infection remain to be elucidated. In present study, Ctenopharyngodon idellus kidney (CIK) cells were infected with GCRV, harvested at 0, 8, 24, 72 h post infection, respectively, then subjected transcriptomics sequencing. Each sample yielded more than 6 Gb clean data 40 million reads. To...
Grass carp ( Ctenopharyngodon idellus ) is an important aquaculture species in China that affected by serious diseases, especially hemorrhagic disease caused grass reovirus (GCRV). have previously shown age-dependent susceptibility to GCRV, however, the mechanism which this occurs remains poorly understood. Therefore, we performed transcriptome and metabolome sequencing on five-month-old (FMO) three-year-old (TYO) identify potential mechanism. Viral challenge experiments showed FMO fish were...
Bacterial translocation was observed in critical illness and patients with chronic diseases such as liver cirrhosis kidney disease (CKD). Hypokalemia is a common complication these diseases. Whether low potassium diet may increase intestinal permeability result bacterial lack of evidence. The present study aimed to investigate the potential effects LK on permeability.Grade 8-week-old male Bal B/C mice were randomly placed either normal (NK) mouse chow or (LK) for 28 days. Intestinal...