A5032642837- Nanoplatforms for cancer theranostics
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
- Photodynamic Therapy Research Studies
- COVID-19 and Mental Health
- RNA modifications and cancer
- Sepsis Diagnosis and Treatment
- Kruppel-like factors research
- Endoplasmic Reticulum Stress and Disease
- Tryptophan and brain disorders
- Advanced Nanomaterials in Catalysis
- Microtubule and mitosis dynamics
- Alzheimer's disease research and treatments
- Long-Term Effects of COVID-19
- Radiation Therapy and Dosimetry
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
Guangxi Medical University
2022-2024
Xiamen Medical College
2024
Shandong University
2022-2024
Jilin University
2024
Beijing Chao-Yang Hospital
2022-2023
Capital Medical University
2022-2023
Core Laboratories (United States)
2023
Abbott (United States)
2023
Lake County
2023
Zhongshan Hospital of Xiamen University
2009-2022
MicroRNAs are stable and easy to detect in plasma. The plasma levels of microRNAs often changed disease conditions, including cancer. This makes circulating a novel class biomarkers for cancer diagnosis. Analyses online microRNA data base revealed that expression level three microRNAs, microRNA-24 (miR-24), microRNA-320a (miR-320a), microRNA-423-5p (miR-423-5p) were down-regulated colorectal (CRC). However, whether the these can serve as CRC diagnosis prognosis is not determined.Plasma...
Abstract Background FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes. Recent results suggest that highly expressed in hepatocytes under stress caused by starvation, hepatosteatosis, Hepatic elicits benefits targeting adipocytes of the peripheral adipose tissue through transmembrane FGFR1-KLB complex. Ablation FGFR1 resulted increased hepatosteatosis starvation conditions abrogation anti-obesogenic action FGF21. These indicate may be...
The acquisition of ectopic fibroblast growthfactor receptor 1 (FGFR1) expression is well documented in prostate cancer progression. How it contributes to progression not fully understood, although known confer a growth advantage and promote cell survival. Here, we report that FGFR1 tyrosine kinase reprograms the energy metabolism cells by regulating lactate dehydrogenase (LDH) isozymes. increased LDHA stability through phosphorylation reduced LDHB promoting its promoter methylation, thereby...
Despite advances in cancer therapy, the existence of self-renewing stem cells (CSC) can lead to tumor recurrence and radiation resistance, resulting treatment failure high mortality patients. To address this issue, a near-infrared (NIR) laser-induced synergistic therapeutic platform has been developed by incorporating aggregation-induced emission (AIE)-active phototheranostic agents sulfur dioxide (SO2 ) prodrug into biocompatible hydrogel, namely TBH, suppress malignant CSC growth....
Abstract The induction of tumor carbonyl stress is reported to efficiently revert immune suppression in the microenvironment and enhance cancer immunotherapy. However, low oxygen concentration due inherent hypoxia limits its catalytic effect. Herein, an injectable thermosensitive hydrogel system (named APH) developed for co‐loading near‐infrared (NIR) aggregation‐induced emission (AIE) nanoparticles plasma amine oxidase (PAO) boosting enhancing antitumor immunity. Upon 808 nm NIR laser...
Abstract Compared to conventional radiotherapy (RT), FLASH‐RT delivers ultra‐high dose radiation, significantly reducing damage normal tissue while guaranteeing the effect of cancer treatment. However, recurrence and metastasis frequently occur after all RT due existence intractable stem cells (CSCs). To address this, a biomimetic nanoplatform (named TAFL) tumor‐derived exosome fusion liposomes is designed by co‐loading aggregation‐induced emission photothermal agents, TPE‐BBT, anti‐cancer...
The self-renewal and differentiation properties of cancer stem cells (CSCs) result in chemoresistance breast cancer. Even though numerous drugs have been developed to target CSCs, they suffered from inefficient delivery accumulation at the focal site. Here, a thermoresponsive hydrogel is by coencapsulating aggregation-induced emission (AIE)-active photothermal agent thioridazine (THZ), demonstrating controllable system triggered AIE augment THZ-mediated CSC ablation. Upon near-infrared laser...
The development of strategies to maintain the long-term presence reactive oxygen species in tumor sites remains an urgent issue be addressed. Here, we design platelet exosome hybrid liposome nanovesicles (named platelet-derived liposomes co-loaded with DPDPy and chloroperoxidase [DCHL]) co-loading aggregation-induced emission (AIE) photosensitizers chloroperoxidases facilitate uninterrupted singlet (1O2) generation for enhancing breast cancer immunotherapy. When DCHL enters cells, it lyses...
Background: In recent years, the widespread use of lipid-lowering drugs, especially statins, has attracted people’s attention. Statin may be potentially associated with a reduced risk breast cancer. Objective: To explore relationship between statin and cancer risk. And further potential role statins in adjuvant treatment Methods: Data for Mendelian randomization portion study were obtained from genome-wide association studies common cancers UK Biobank FinnGen Global Lipid Genetics...
MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal‐specific MAP1A and MAP1B, bridges autophagic components with microtubules mitochondria to affect autophagosomal biogenesis degradation. Mitochondrion‐associated protein LRPPRC functions as an inhibitor for autophagy initiation protect from interact each other may collaboratively regulate although the underlying mechanism yet unknown. Previously, we have reported that levels serve prognosis marker patients prostate...
BACKGROUND Autophagy has recently been found to play important roles in tumorigenesis and leucine‐rich pentatricopeptide repeat motif‐containing protein (LRPPRC) identified as an inhibitor that suppresses autophagy mitophagy maintains mitochondrial activity. The authors hypothesized LRPPRC levels can be used a biomarker for the diagnosis prognosis of prostate cancer. METHODS Immunochemistry analysis was performed evaluate 112 samples collected from patients with adenocarcinoma (PCa) 38...
Abstract Purpose: (i) To investigate the expression of E3 ligase, RNF126, in human invasive breast cancer and its links with outcomes; (ii) to test hypothesis that RNF126 determines efficacy inhibitors targeting cell-cycle checkpoint kinase, CHEK1. Experimental Design: A retrospective analysis by immunohistochemistry (IHC) compared staining 110 78 paired adjacent normal tissues clinicopathologic data. Whether controls CHEK1 was determined chromatin immunoprecipitation a promoter driven...
Abstract Background Bone metastasis is the leading cause of mortality and reduced quality life in patients with metastatic prostate cancer (PCa). Long non-coding RNA activated by DNA damage (NORAD) has been observed to have an abnormal expression various cancers. This article aimed explore molecular mechanism underlying regulatory role NORAD bone PCa. Methods clinical PCa tissues cell lines was detected application qRT-PCR. Cancer cells were then transfected plasmids expressing NORAD, after...
Article Magnetically-Driven Reconfigurable Cilium Array with Tunable Wettability for Dynamic Display and Controllable Microreactio Zijing Quan 1, Yuhan Zhang 1,*, You Pan Zhongyi Yang Chen Fawei Rui Letian Li Bo 1,2,*, Shichao Niu 1,2,3,*, Zhiwu Han 1,2,3, Luquan Ren 1,2,3 1 Key Laboratory of Bionic Engineering (Ministry Education), Jilin University, Changchun 130022, China 2 National Automotive Chassis Integration Bionics, 3 Institute Structured Architected Materials, Liaoning Academy...
Background Multiple lines of evidence indicate a connection between the pathogenesis coronavirus disease 2019 (COVID-19) and psychiatric diseases (PDs). To improve treatment management individuals with psychosis COVID-19, we evaluated biomarkers PD patients, including those schizophrenia (SCZ), bipolar disorder (BD), major depression (MDD), along COVID-19. Methods In this study, 104 inpatients concurrent COVID-19 (PD+), same patients after they had recovered from (PD-), 97 healthy controls...
The mammalian cyclin kinase subunit (Cks) family has two members, Cks1 and Cks2, which were identified based on the protein sequence homology to yeast Cks. Overexpression of Cks2 been reported be associated with high aggressiveness a poor prognosis in various malignancies, including gastric, breast prostate carcinomas. Yet, whether are overexpressed hepatocellular carcinoma (HCC) remains uncharacterized.To investigate overexpression Cks is clinically relevant HCC, expression patterns HCC...
Abstract Background A role for neural precursor cell-expressed developmentally downregulated gene 4 (NEDD4) in tumorigenesis has been suggested. However, information is lacking on its breast tumor biology. The purpose of this study was to determine the NEDD4 promotion growth and progression cancer (BC) evaluate clinicopathologic prognostic significance NEDD4. Methods impact expression BC cell determined by Cell Counting Kit-8 colony formation assays. Formalin-fixed paraffin-embedded...
Cold exposure (CE) therapy can quickly induce tumor starvation by brown adipose tissue (BAT) thermogenesis. Exploring the combined antitumor mechanism of CE and traditional therapies (such as radiotherapy (RT)) is exciting promising. In this study, we investigated effect in combination with nitric oxide (NO) gas on sensitizing tumors to RT promoting radio-immunotherapy. We first constructed a liposome (SL) loaded NO prodrug S-nitroso-N-acetylpenicillamine (SNAP). When SL injected,...
Cerebral demyelination is possibly one of the main pathological factors involved in development schizophrenia. Our previous studies have showed that Areca catechu nut extract could ameliorate cognitive decline by facilitating myelination processes frontal cortex a cuprizone (CPZ)-induced mouse model The aim present study was to evaluate effects arecoline, alkaloids A. extract, on memory impairment and cerebral CPZ-treated mice. Mice were treated with CPZ (0 or 0.2%) chow food arecoline...