A5038318418- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- IL-33, ST2, and ILC Pathways
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Glycosylation and Glycoproteins Research
- Protein Tyrosine Phosphatases
- PARP inhibition in cancer therapy
- FOXO transcription factor regulation
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Calcium signaling and nucleotide metabolism
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Immune cells in cancer
- Heat shock proteins research
- RNA modifications and cancer
Xinxiang Medical University
2016-2025
First Affiliated Hospital of Xinxiang Medical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Baker Heart and Diabetes Institute
2020
Indiana University School of Medicine
2012-2016
Indiana University – Purdue University Indianapolis
2012-2016
Hunan Normal University
2005
Autophagy plays a critical role in cell survival from prolonged starvation and recycling of aggregated proteins damaged organelles. One the essential genes involved autophagic initiation is autophagy-related 14 (Atg14), also called Barkor for Beclin 1-associated key regulator. Although its crucial process has been reported, gene regulation Atg14 metabolic functions remain unclear. In this work we have identified that regulated by forkhead box O (FoxO) transcription factors circadian rhythms...
Cholesterol homeostasis is crucial for cellular function and organismal health. The key regulator the cholesterol biosynthesis sterol-regulatory element binding protein (SREBP)-2. biochemical process physiological of SREBP-2 have been well characterized; however, it not clear how this gene epigenetically regulated. Here we identified sirtuin (Sirt)6 as a critical factor Srebp2 regulation. Hepatic deficiency Sirt6 in mice leads to elevated levels. On mechanistic level, recruited by forkhead...
Forkhead transcription factors FoxO1/3/4 have pleiotrophic functions including anti-oxidative stress and metabolism. With regard to glucose metabolism, most studies been focused on FoxO1. To further investigate their hepatic functions, we generated liver-specific knockout mice (LTKO) examined collective impacts homeostasis under physiological pathological conditions. As compared wild-type mice, LTKO had lower blood levels both fasting non-fasting conditions they manifested better pyruvate...
Sestrin proteins have been implicated in multiple biological processes including resistance to oxidative and genotoxic stresses, protection against aging-related pathologies, promotion of metabolic homeostasis; however, the underlying mechanisms are incompletely understood. Some evidence suggests that sestrins may inhibit mTORC1 (mechanistic target rapamycin complex 1) through inhibition RagA/B GTPases or activation AMPK; whether also involved mTORC2 regulation function is unclear. To...
Pyruvate dehydrogenase kinases (PDK1-4) play a critical role in the inhibition of mitochondrial pyruvate complex especially when blood glucose levels are low and can be conserved for gluconeogenesis. Under diabetic conditions, Pdk genes, particularly Pdk4, often induced, elevation Pdk4 gene expression has been implicated increased gluconeogenesis liver decreased utilization peripheral tissues. However, there is no direct evidence yet to show what extent that dysregulation hepatic genes...
Research Article25 June 2018Open Access Source DataTransparent process Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation Ming Zhao School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China Department Integrative Biology and Physiology, University Minnesota School, Minneapolis, MN, USA Search for more papers by this author Xiwen Xiong Kaiqun Ren College Hunan Normal Changsha, Hunan, Bing Xu State Key Laboratory Cancer & Institute...
Chronic exposure of pancreatic β-cells to abnormally elevated levels free fatty acids can lead β-cell dysfunction and even apoptosis, contributing type 2 diabetes pathogenesis. In β-cells, sirtuin 6 (SIRT6) has been shown regulate insulin secretion in response glucose stimulation. However, the roles played by SIRT6 lipotoxicity remain poorly understood. Our data indicated that protein mRNA were reduced islets from diabetic aged mice. High concentrations palmitate (PA) also led a decrease...
SIRT6 is a member of sirtuin family deacetylases involved in diverse processes including genome stability, metabolic homeostasis and anti-inflammation. However, its function the adipose tissue not well understood. To examine tissue, we generated two mouse models that are deficient Sirt6 using Cre-lox approach. Two commonly used Cre lines driven by either Fabp4 or Adipoq gene promoter were chosen for this study. The Sirt6-knockout mice Fabp4-Cre line (Sirt6f/f:Fabp4-Cre) had significant...
γ-Glutamine cyclotransferase (GGCT) is an enzyme involved in the metabolic cycle of glutathione (GSH). Abnormal GSH metabolism mostly related to ferroptosis. However, mechanisms supporting aberrant GGCT expression PTC remain be investigated. In this study, we found that knockdown inhibited synthesis and promoted malondialdehyde (MDA) reactive oxygen species (ROS) accumulation, thereby promoting ferroptosis papillary thyroid cancer cells. Pro-GA, specific inhibitor GGCT, subcutaneous tumor...
Radioprotection is an important approach to reduce the side-effects of radiotherapy. The radioprotective effect flavonoids Rosa roxburghii Tratt (FRT) has been confirmed, and mechanism identified as theBcl-2/caspase-3/PARP-1 signaling pathway. In this study, we investigated effects FRT on intercellular adhesion molecule (ICAM), vascular cell protein (VCAM) in addition apoptosis-related proteins such Bax/Bcl-2, p-ERK/ERK, p-p53/p53, p-p38/p38. present focused PARP-1/AIF. Ionizing radiation...
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD)+ biosynthesis. Through its NAD+-biosynthetic activity, NAMPT influences the activity of NAD+-dependent enzymes, such as sirtuins. able to modulate processes involved pathogenesis non-alcohol induced fatty liver disease (NAFLD), but roles plays development alcoholic (ALD) still remain unknown. Here, we show that ethanol treatment suppresses expression Nampt...
Abstract Dynamic regulation of intestinal epithelial cell (IEC) differentiation is crucial for both homeostasis and the response to helminth infection. SIRT6 belongs NAD + -dependent deacetylases has established diverse roles in aging, metabolism disease. Here, we report that IEC Sirt6 deletion leads impaired tuft development type 2 immunity infection, thereby resulting compromised worm expulsion. Conversely, after transgenic mice exhibit enhanced remodeling process more efficient clearance....
Human polymerase delta-interacting protein 1 (PDIP1) is a tumor necrosis factor α and interleukin 6 inducible that interacts directly with proliferating cell nuclear antigen (PCNA) the small subunit (p50) of DNA δ. PDIP1 binds PCNA p50 simultaneously stimulates δ activity in vitro presence, but not absence, PCNA. It has been suggested provides link between cytokine activation replication eukaryotes. Here these authors report cloning two rat genes homologous to human PDIP1, termed...
Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1 and Sp3 belong to the specificity protein Krüppel-like transcription families. They are ubiquitously expressed closely associated with development. We investigate role of in endothelial cells vivo evaluate whether captopril, an angiotensin-converting enzyme inhibitor (ACEI), targets Sp1/Sp3 exert its effects. Inducible endothelial-specific knockout mice generated elucidate their cells....
The loss of inhibitor differentiation-2 (ID2) could lead to the development colitis in mice, supplementation with exogenous ID2 protein might be a potential strategy ameliorate colitis. In this study, effects on Dextran sodium sulfate (DSS)-induced were investigated. Firstly, we confirmed that expression was reduced colon tissues DSS-induced mice and patients ulcerative (UC). Then, constructed recombinant plasmid containing human Id2 gene expressed it Escherichia coli ( E. ) successfully....