A5100339755- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Ultrasound and Hyperthermia Applications
- Nutritional Studies and Diet
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Mass Spectrometry Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Treatment of Major Depression
- Fatty Acid Research and Health
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Analytical Chemistry and Chromatography
- Renal Transplantation Outcomes and Treatments
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Schizophrenia research and treatment
- Lung Cancer Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological Disease Mechanisms and Treatments
- Advanced Proteomics Techniques and Applications
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
Capital Medical University
2015-2024
Xizang Minzu University
2024
Affiliated Hospital of Qingdao University
2024
Qingdao University
2024
Beijing Anding Hospital
2024
Nanjing University
2023
Beijing Chao-Yang Hospital
2015-2023
Beijing Chaoyang Emergency Medical Center
2022
First Affiliated Hospital of Zhengzhou University
2020-2021
Capital University
2019-2020
Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential mechanisms require further exploration. We aimed to reveal HSYA against acute TBI by an integrated strategy combining metabolomics with network pharmacology. controlled cortical impact (CCI) rat model was established, neurological functions were evaluated. Metabolomics tissues used identify differential...
A mass spectrometric platform was built for in-depth profiling of mutational landscape cis -diol metabolites from the healthy to primary liver cancer (PLC) patients. This method enabled more precise PLC diagnosis than protein marker-based methods.
A selective, robust ultrahigh performance liquid chromatography tandem mass spectrometry method was developed for the first time simultaneous determination of next-generation antitumor tyrosine kinase inhibitors in rat plasma using protein precipitation extraction.
Anlotinib is an oral small molecule inhibitor of multiple receptor tyrosine kinases (RTKs), which was approved by the National Medical Products Administration (NMPA) China in 2018 for third-line treatment non-small cell lung cancer (NSCLC). Here, first time, longitudinal pharmacometabonomics explored predicting malignant tumor patient responses to anlotinib, including metabolic phenotype variation, drug efficacy, and toxicity. A total 393 plasma samples from 16 subjects collected a phase I...
Abstract Background and objective Definity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as perflutren, microspheres, which initially designed to enhance echocardiographic images. With no pharmacologic action, can increase the backscatter resulting enhanced signals. The this study was determine pharmacokinetics (PKs), Pharmacodynamics (PDs) safety in healthy male female Chinese volunteers. Methods A simple GC-MS method developed...
□ A rapid and sensitive analytical method of liquid chromatography combined with tandem mass spectrometry (LC–MS/MS) was established for simultaneous quantitative analysis hydrazine, methylhydrazine, 1,1-dimethylhydrazine in rat plasma. Plasma samples were pretreated protein precipitation optimized derivatization procedure. Separation achieved using acetonitrile water containing 5 mM ammonium acetate as gradient elution. The transition ion-pairs (m/z) monitored three hydrazine derivatives...
Sonazoid is an ultrasound contrast agent based on microbubbles (MB) containing perfluorobutane (PFB) gas. approved in Japan, Korea and Norway for contrast-enhanced ultrasonography of focal liver lesions breast (Japan only). The objective this study was to determine the pharmacokinetics (PKs) safety Chinese healthy volunteers (HVs) evaluate potential ethnic differences PKs between Caucasian HVs. administered as intra-venous bolus injection at clinical dose 0.12 μL or 0.60 MB/kg body weight...
Background: The present study was designed to examine the association of circulating cholesterol with cognitive function in non-demented community aging adults. Methods: This a cross-sectional including 1754 Chinese adults aged 55-80 years. between serum levels and examined. Participants were categorized into four groups according quartile TC (total cholesterol), High Density Lipoprotein Cholesterol (HDL-c), Low (LDL-c) HDLc/ LDL-c ratio. difference performance among compared. Logistic...
Amino acid analysis or metabonomics requires large-scale sample collection, which makes storage a critical consideration. However, functional amino acids are often neglected in metabolite stability studies because of the difficulty detecting and accurately quantifying them with most methods. Here, we investigated related amines human serum following different preprocessing pre-storage procedures. Serum samples were collected subjected to three conditions; cold (4°C), room temperature (22°C),...
Metabolic pathway disturbances associated with drug-induced liver injury remain unsatisfactorily characterized. Diagnostic biomarkers for hepatotoxicity have been used to minimize and increase the clinical safety. A metabolomics strategy using rapid-resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS) analyses multivariate statistics was implemented identify potential hydrazine-induced hepatotoxicity. The global serum urine of 30 hydrazine-treated rats at 24 or 48 h...
Abstract In‐depth profiling of embryogenesis‐associated endogenous and exogenous metabolic changes can reveal potential bio‐effects resulting from human‐made chemicals underlying mechanisms. Due to the lack potent tools for monitoring spatiotemporal distribution bio‐transformation behavior dynamic metabolites at single‐cell resolution, however, how what extent environmental may influence or interfere embryogenesis largely remain unclear. Herein, a zero‐sample‐loss micro‐biopsy‐based mass...
Robust UPLC/MS/MS method was firstly developed and validated; arachidonic acid cascade metabolites have been shown to be associated with anlotinib longitudinal metabolomics.
This study was designed to examine whether AD pathological phenotype in APPswe/PS1dE9 (APP/PS1) mice exposed continuous high-fat diet predispose these murine models metabolic dysfunction and neuropathological impairments. One-month old male APP/PS1 C57BL/6J were provided with 60% for 6.5 months. After dietary intervention, phenotyping, cognitive behaviors, AD-related brain changes insulin signaling compared. high fat induced hyperglycemia, hypercholesterolemia, aggravated inflammatory stress...
Xuefu Zhuyu decoction (XFZYD) performs multiple functions for traumatic brain injury (TBI) treatment. However, its clinical application is limited by the incomplete exploration of targets and inadequate discussion mechanisms. We aimed to investigate metabolic alterations XFZYD in acute chronic stages TBI. Sprague-Dawley rats were randomly divided into sham, controlled cortical impact (CCI) group. Behavioral histopathological tests used evaluate neuroprotective effects. Coagulation assays...
Aim: Olanzapine (OLZ) is the first-line, cost-effectiveness treatment for schizophrenia in China. A quantitative ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method determination of OLZ human plasma was developed. Results: LC separation achieved on Waters XBrige C18 column. ESI+ involved and multiple reaction monitoring transitions were at m/z 313.2→256.1 316.2→256.1 IS (d3-OLZ). The linear range 0.1-20 ng/ml with LLOQ 0.1 ng/ml. Accuracy precision within...
Neurotransmitters (NTs) are specific endogenous metabolites that act as "messengers" in synaptic transmission and widely distributed the central nervous system. Olanzapine (OLZ), a first-line antipsychotic drug, plays key role sedation hypnosis, but, it presents clinical problems with narrow therapeutic window, large individual differences serious adverse effects, well an unclear mechanism vivo. Herein, simultaneous targeted NT quantification nontargeted metabolomics method was developed...
What is known and objective Gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, exhibited a wide interindividual variability in pharmacokinetics. In present study, we aimed to evaluate impact single-nucleotide polymorphisms metabolizing enzymes transporters on gefitinib disposition healthy Chinese subjects. Methods Fourteen polymorphisms, including ATP-binding cassette (ABC) cytochrome P450 enzymes, were genotyped by Sanger sequencing, concentration was measured...
Olanzapine, a second-generation atypical antipsychotic drug, is widely used for schizophrenia and moderate to severe mania associated with bipolar disorders. This open-label, randomized, single-dose, 2-sequence, 2-period crossover, comparative pharmacokinetic study assessed the bioequivalence of 5 mg olanzapine administered in tablet (R) or disintegrating (T) formulation healthy Chinese volunteers under both fasting fed conditions. Numbers enrolled subjects were 30 24 treatments,...
The correlation between dietary fatty acid (FA) intake and serum lipid profile levels with cognition in the aged population has been reported by previous studies. However, association of FA subjects type 2 diabetes mellitus (T2DM) is seldom reported. A cross-sectional study was conducted to explore profiles Chinese T2DM. total 1,526 were recruited from communities. Fasting blood samples collected for parameter measurement. food frequency questionnaire (FFQ) method applied a survey. Cognition...
The level of glycated hemoglobin (HbA1c ) has been recognized as an important indicator long-term glycemic control. However, the HbA1c measurement is not currently included a diagnostic determinant in China. Current study aims to assess candidate modified International Federation Clinical Chemistry reference method for forthcoming standardization measurements China.The concentration was measured using high-performance liquid chromatography-electrospray ionization-mass spectrometry...