A5022277953- Nanocluster Synthesis and Applications
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Advanced Nanomaterials in Catalysis
- Epigenetics and DNA Methylation
- vaccines and immunoinformatics approaches
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Sirtuins and Resveratrol in Medicine
- Inflammasome and immune disorders
- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- Circular RNAs in diseases
- Cleft Lip and Palate Research
- Effects of Radiation Exposure
Inner Mongolia University
2025
Henan Provincial People's Hospital
2020-2024
Zhengzhou University
2020-2024
Henan University
2020-2021
Zhengzhou Central Hospital
2020
Xinxiang Medical University
2017
Abstract Gemcitabine is the first-line chemotherapy drug for cholangiocarcinoma (CCA), but acquired resistance has been frequently observed in CCA patients. To search potential long noncoding RNAs (lncRNAs) involved gemcitabine resistance, two resistant cell lines were established and dysregulated lncRNAs identified by lncRNA microarray. Long intergenic non-protein coding RNA 665 (LINC00665) found to rank top 10 upregulated our study, high LINC00665 expression was closely associated with...
Silicon has an ultra-high theoretical specific capacity, making it ideal material to replace traditional graphite anodes. However, the volume expansion of silicon leads its poor cycling stability. In this work, a high-compacted density silicon-carbon anode (PMMA@Si/C) is presented. The structure poly(methyl methacrylate) (PMMA) mixed with creates pre-positioned space on surface, providing room for during cycling. It was also blended commercial and after carbonization carbon layer formed...
Cholangiocarcinoma (CCA) is a malignant tumor in the world. LncRNA HOX transcript antisense intergenic RNA (HOTAIR) was identified as crucial regulator various cancers including CCA. This study aimed to unravel functions of HOTAIR and its biological mechanism CCA, hinting for new therapeutic targets The levels HOTAIR, miR-204-5p HMGB1 CCA tissues cell lines (HuB28 HuCCT1) were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Western blot conducted detect protein LC3-I,...
Platinum (Pt)-based chemotherapy drugs such as cisplatin are the first line and core options for treatment of ovarian cancer (OC), while resistance has a worse prognosis low 5 year survival rate patients. Chemotherapeutic synthesized from nanomaterials have shown great potential in biomedicine; however, research into their application OC is rarely discussed. This study proposed to elucidate anti-tumor effects polyethylenimine (PEI)-caged platinum nanoclusters (Pt NCs) on cisplatin-resistant...
With a long history of application in Chinese traditional medicine, berberine (BBR) was reported to exhibit healthspan-extending properties some age-related diseases, such as type 2 diabetes and atherosclerosis. However, the antiaging mechanism BBR is not completely clear. By means hydrogen peroxide- (H2O2-) induced premature cellular senescence model, we found that low-concentration preconditioning could resist human diploid fibroblasts (HDFs) measured by senescence-associated...
Abstract Background Epithelial ovarian cancer (OC) is the fourth leading cause of cancer-related deaths in women, with a 5-year survival rate 30%-50%. Platinum resistance chief culprit for high recurrence and mortality rates. Several studies confirm that metabolic regulation ubiquitinating enzymes plays vital role platinum OC. Methods In this study, we selected ubiquitin-conjugating enzyme E2S (UBE2S) as candidate gene validation. The levels UBE2S expression were investigated using TCGA,...
Background: Ovarian cancer (OV) is one of the most common gynecological malignancies worldwide, and its immunotherapy has considerable prospects. Multiple members CMTM family were aberrantly expressed in human cancers controlled key malignant biological processes immune regulation development. However, little known about function this gene ovarian cancer, especially terms immunity. Methods: GEPIA, Oncomine, HPA, Kaplan-Meier plotter, cBioPortal, GeneMANIA, TIMER used to analyze differential...
The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). activated β-catenin. aim this study was track AEC at different phases injury following thoracic irradiation examine expression β-catenin, let-7 identify their role in differentiation. Results showed that coexpression prosurfactant protein C (proSP-C, an...
According to the 2020 GLOBOCAN Global Cancer Women's Data, ovarian cancer is eighth most common tumor in humans. Still, its mortality rate ranks first among all gynecological tumors, with a 5-year survival of 30% 50%. Widespread clinical use platinum-based drugs has improved outcomes patients cancer, but organ toxicity and drug resistance hinder their anticancer effects. In particular, platinum an important reason for cancer's high recurrence mortality. With development chemotherapeutic...
The role of type II alveolar epithelial stem cells (AEC II) for repair in radiation-induced lung fibrosis (RILF) remains largely unknown, mainly because AEC phenotype's spontaneous change vitro. Cell differentiation status is determined by Lin28 and let-7 miRNAs see-saw-pattern. Lin28, a repressor cell marker, activated β-catenin. expression β-catenin regulated GSK-3β/TGF-β1 signaling. To understand the true RILF, we freshly isolated primary directly from thoracically irradiated lungs. We...
Adequate prognostic prediction of Uterine Corpus Endometrial Carcinoma (UCEC) is crucial for informing clinical decision-making. However, there a scarcity research on the utilization nomogram evaluation model that incorporates pyroptosis-related genes (PRGs) in UCEC.
In the past few years, platinum nanomaterials (Pt NMs) have gained attraction owing to their ability address drawbacks of classical Pt-based chemotherapy drugs including drug resistance and clinical side effects, which been preliminarily used in lung cancer, liver gynecological etc. order investigate effect Pt NMs on hematopoietic tumors, ultra-small nanoclusters NCs) were employed clarify targeting recognition, cellular uptake, effective therapy vivo for chronic myeloid leukemia (CML)...
Background: At the pan-cancer level, exploring expression and prognostic significance of a gene, such as UBE2S, will help to gain insight into role gene its feasibility for cancer screening, prognosis assessment even therapy. Methods: The Cancer Genome Atlas, Human Protein Kaplan-Meier, Tumor Immunology Estimation Resource other databases were used analyze UBE2S at immune microenvironment. Immunohistochemistry samples tumor tissue collected in our clinic taken verification. Results: is...
Osteosarcoma, a prevalent primary bone cancer in children, exhibits poor prognosis due to the high prevalence of drug resistance. The objective this study was investigate potential fluorescent ultrafine polyethylenimine-coated caged platinum nanoclusters (PEI-Pt NCs) as an antitumor agent osteosarcoma. focus involved utilization osteosarcoma cells (U2-OS and MG-63) normal control (hBMSC) subjects investigation. capacity PEI-Pt NCs enter observed through implementation confocal microscopy....
Dysregulation of the adipo-osteogenic differentiation balance mesenchymal stem cells (MSCs), which are common progenitor adipocytes and osteoblasts, has been associated with many pathophysiologic diseases, such as obesity, osteopenia, several neurodegenerative disorders. Growing evidence suggests that lipid metabolism is crucial for maintaining cell homeostasis differentiation, however, detailed underlying mechanisms largely unknown. In this study, we demonstrate CYP46A1 genes key...
Abstract Background: Uterine Corpus Endometrial Carcinoma (UCEC) is difficult to evaluate the prognosis. The prognostic evaluation model based on pyroptosis-related genes (PRGs) has shown good predictive power for prognosis in tumors, but there no relevant research UCEC. Methods: Based gene expression data and clinical information of UCEC patients from TCGA database, PRGs related were screened out. PRGs, a was established. Comprehensive analysis characteristics performed. potential molecular...