A5100730384- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Renal cell carcinoma treatment
- Porphyrin and Phthalocyanine Chemistry
- Colorectal Cancer Treatments and Studies
- NF-κB Signaling Pathways
- Gut microbiota and health
- Advanced Biosensing Techniques and Applications
- Cancer Cells and Metastasis
- Effects of Radiation Exposure
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Protein Tyrosine Phosphatases
- Yersinia bacterium, plague, ectoparasites research
- Biotin and Related Studies
- Probiotics and Fermented Foods
Qinghai Provincial Peoples Hospital
2023-2025
Southern Medical University
2015-2025
Second Affiliated Hospital of Zhejiang University
2025
Nanfang Hospital
2025
Anhui University of Science and Technology
2025
Henan Provincial People's Hospital
2011-2023
Henan University
2020-2023
Zhengzhou University
2017-2023
Affiliated Hospital of Jining Medical University
2021
Emerging evidence has indicated that long non‐coding RNA plays an important role in carcinogenesis at the transcriptional and post‐translational levels. The regulation of carcinogenesis‐related effectors is potent determination tumor initiation progression. In current study, FOXD 2‐ AS 1 was found to interact with micro (miR)‐185‐5p modulate proliferation, migration, invasion colorectal cancer ( CRC ) cells. Interestingly, expression cell division control 42 significantly influenced by...
Abstract Background & Aims Elevation of high‐mannose glycans is a common feature malignant cells and has been suggested to be the basis for alternative cancer therapy several years. Here we want investigate antitumour effect pseudomonas aeruginosa‐mannosesensitive haemagglutinin ( PA ‐ MSHA ), genetically engineered heat‐inactivated strain with mannose‐sensitive binding activity, on hepatocellular carcinoma HCC ). Methods Tumourigenicity metastatic potentials were studied after treatment...
Exploring the variability of intestinal flora patients with hepatic blastocysticercosis and searching for members microflora that may play a role in disease process by means macro-genome sequencing technology. A case-control study was used to include fecal samples from vesicular schistosomiasis admitted Qinghai Provincial People's Hospital between October 2023 January 2024 individuals attending health checkups. The experimental group (AE group) consisted 10 liver control (NC 9 Macrogenomic...
Developing a simple analytical method suitable for therapeutic drug monitoring in clinical setting is key to establishing guidelines on accurate dose administration and the advancement of precision medicine. We devised rapid through combination streptavidin-modified microparticles time-resolved fluorescence immunoassay monitoring. The performance this was investigated validated using samples. By determination doxorubicin concentration, proposed assay has shown satisfactory linear range...
Introduction The prognosis for epithelial ovarian cancer (EOC) is exceedingly poor, with patients diagnosed stage III/IV tumours typically offered cytoreductive surgery in conjunction chemotherapy as a standard treatment option. This approach intended to reduce the risk of and address cancers that are not amenable surgical intervention. A promising alternative important option neoadjuvant (NACT) interstitial tumour surgery. combination immunotherapy has recently demonstrated remarkable...
Objective: To explore the regulatory mechanism of voltage-dependent anion channel 1(VDAC1) on proliferation, migration and invasion lung adenocarcinoma(LUAD) cells. Methods: This study employed a combination bioinformatics experimental validation methods, conducting analysis cytological in central laboratory School Medicine, Anhui University Science Technology from February 2023 to August 2024.Clinical histological specimen was performed using immunohistochemistry, retrospective conducted 5...
The purpose of this study was to evaluate the anti–head and neck squamous cell carcinoma (anti‐HNSCC) activity by C6 ceramide multikinase inhibitor PKC412. Experiments were performed on HNSCC lines (SQ20B SCC‐9) primary human oral cells. Results showed that PKC412 inhibited proliferation without provoking apoptosis activation. Cotreatment significantly augmented PKC412‐induced lethality in decreased Akt–mammalian target rapamycin (mTOR) activation cells, facilitated with cotreatment...
The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). activated β-catenin. aim this study was track AEC at different phases injury following thoracic irradiation examine expression β-catenin, let-7 identify their role in differentiation. Results showed that coexpression prosurfactant protein C (proSP-C, an...
The role of type II alveolar epithelial stem cells (AEC II) for repair in radiation-induced lung fibrosis (RILF) remains largely unknown, mainly because AEC phenotype's spontaneous change vitro. Cell differentiation status is determined by Lin28 and let-7 miRNAs see-saw-pattern. Lin28, a repressor cell marker, activated β-catenin. expression β-catenin regulated GSK-3β/TGF-β1 signaling. To understand the true RILF, we freshly isolated primary directly from thoracically irradiated lungs. We...
Transdifferentiation of type II alveolar cells (AECII) is a major cause for radiation-induced lung fibrosis (RILF). Cell differentiation phenotype determined by Lin28 (undifferentiated marker) and let-7 (differentiated in see-saw-pattern. Therefore, can be extrapolated based on Lin28/let-7 ratio. activated β-catenin. To the best our knowledge this study was first to use single primary AECII freshly isolated from irradiated lungs fibrosis-resistant C3H/HeNHsd strain further confirm RILF...
Objective: To assess the relationship between Helicobacter pylori (Hp) infection and primary open-angle glaucoma (POAG); meantime, to explore possible mechanism of POAG induced by Hp. Methods: 30 consecutive patients, angle-closure (PACG) cataract patients were recruited divided into three groups according different diseases. The sera aqueous humor samples collected used detect Hp-specific IgG antibody (Hp-Ab) with dot immunogold filtration assay (DIGFA). 14C-urea breath test (14C-UBT) was...
Objective To study the effects of indomethacin on proliferation and invasion hepatocellular carcinoma (HCC) cell line MHCC97L with metastatic potential effect growth metastasis HCC. Methods (1) In vitro; Proliferation, Transwell assay, motility vascular endothelial factor (VEGF) matrix metalloproteinase-2 (MMP-2) protein activity were evaluated after cells treated 0. 2 mmol/L indomethacin. (2)In vivo: Mice bearing xenografts in liver randomly divided into control groups. At end sixth week,...
To explore the drug resistance of Isolated From Blood Culture Escherichia coli (
e15102 Background:FBI-1 is a recently characterized proto-oncoprotein of the POZ domain Krüppel-like (POK) family transcription factors. Although several studies provide evidence that FBI-1 an important gene regulator in CRC, no analysis any correlation between expression and preoperative radiotherapy (RT) has been studied rectal cancers. Methods: This study included patients with cancer participated Swedish clinical trial RT 1987 1990. Patients were divided into (62) non-RT (77) groups....
3574 Background: CPGJ602 is a recombinant anti-EGFR human-mouse chimeric monoclonal antibody. plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) may have efficacy in KRAS/NRAS/BRAF wild-type metastatic colorectal cancer. Methods: In this open-label, randomized trial, patients who had received no previous treatment were randomly assigned (2:2:1) to receive CPGJ60（325mg/m 2 , q2w) mFOLFOX6 (biweekly group), (400 mg/m initial dose followed by 250 /week thereafter) (weekly group)...
ABSTRACT The microbiota hosted in the pig gastrointestinal tract are important for productivity of livestock. However, individual species and functional repertoires that make up gut microbiome remain largely undefined. Here we comprehensively investigated genomes functions piglet using culture-based metagenomics approaches. A collection included 266 cultured 482 metagenome-assembled (MAGs) were clustered to 428 across 10 phyla was established. Among these species, 333 represent potential new...