A5074373116- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Hybrid Renewable Energy Systems
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Immune cells in cancer
Xinxiang Medical University
2020-2024
Air Force Medical University
2021-2023
Abstract N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the of m6A macrophages are still unknown. Here, we discover ablation Mettl3 myeloid cells promotes tumour growth and metastasis vivo. In contrast wild-type mice, Mettl3-deficient mice show increased M1/M2-like tumour-associated macrophage regulatory T cell infiltration into tumours. sequencing reveals loss METTL3 impairs YTHDF1-mediated...
Enhancer of Zeste Homolog 2 (EZH2), a key epigenetic regulator, is involved in breast cancer progression and metastasis. LOXL4 increasingly recognized as an important player progression. To date, how EZH2 regulates the remains unclear. Methods: We evaluated association between LOX family proteins invasive carcinoma through starBase v2.0 analysis, its correlation with tumorigenesis using Oncomine dataset. then applied miRcode data combined gene expression omnibus (GEO) to screen candidate...
Alzheimer's disease (AD) is a heterogeneous with complex clinicopathological characteristics. To date, the role of m6A RNA methylation in monocyte-derived macrophages involved progression AD unknown. In our study, we found that methyltransferase-like 3 (METTL3) deficiency improved cognitive function an amyloid beta (Aβ)-induced mouse model. The mechanistic study showed METTL3 ablation attenuated modification DNA methyltransferase 3A (Dnmt3a) mRNAs and consequently impaired YTH...
Abstract Hepatic glycogen is the main source of blood glucose and controls intervals between meals in mammals. storage mammalian pups insufficient compared to their adult counterparts; however, detailed molecular mechanism poorly understood. Here, we show that, similar pattern, N6-methyladenosine (m6A) modification mRNAs gradually increases during growth mice liver. Strikingly, hepatocyte-specific Mettl3 knockout mice, loss m6A disrupts liver storage. On mechanism, mRNA Gys2, liver-specific...
Abstract Background Tumor-associated macrophages (TAMs) significantly influence the progression, metastasis, and recurrence of esophageal squamous cell carcinoma (ESCC). The aberrant expression long noncoding RNAs (lncRNAs) in ESCC has been established, yet role lncRNAs TAM reprogramming during progression remains largely unexplored. Methods TAM-related were identified by intersecting differentially expressed with immune-related performing immune infiltration analysis. profile clinical...
Abstract Hepatic glycogen is the main source of blood glucose and controls intervals between meals in mammals. storage mammalian pups insufficient compared to their adult counterparts; however, detailed molecular mechanism poorly understood. Here, we showed that, similar pattern, N6-methyladenosine (m6A) modification mRNAs gradually increases during growth mice liver. Strikingly, liver-specific Mettl3 knockout mice, loss m6A disrupts liver storage. On mechanism, screened identified that...