A5046980371- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Mass Spectrometry Techniques and Applications
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- Renal and related cancers
- Gastric Cancer Management and Outcomes
- Urinary Bladder and Prostate Research
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Hippo pathway signaling and YAP/TAZ
- Urological Disorders and Treatments
- Eosinophilic Esophagitis
- TGF-β signaling in diseases
- Opportunistic and Delay-Tolerant Networks
Shanghai Jiao Tong University
2007-2025
Renji Hospital
2004-2025
Fudan University
2013-2024
Sun Yat-sen University
2022-2024
Zhejiang University
2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Inner Mongolia Agricultural University
2024
Shanghai Ninth People's Hospital
2016-2024
Zhongshan Hospital
2019-2024
Guilin Medical University
2023-2024
Study Type – Therapy (RCT) Level of Evidence 1b OBJECTIVE To present 2‐year follow‐up data a randomized clinical trial comparing bipolar transurethral resection in saline (TURIS) with monopolar the prostate (TURP). PATIENTS AND METHODS In all, 100 consecutive patients benign prostatic hyperplasia (BPH) were to TURIS or TURP. The breath ethanol test was used before and every 10 min during surgery assess fluid absorption. Complications treatment efficacy evaluated after surgery. RESULTS...
Single-cell proteome analysis has always been an exciting goal because it provides crucial information about cellular heterogeneity and dynamic change. Here we presented integrated device (iPAD) for 100 living cells (iPAD-100) that might be suitable single-cell analysis. Once were cultured, the iPAD-100 could applied to inject cells, transform into peptides, produce protein identification results with total automation. Due major obstacle detection limit of mass spectrometry, analyze cells....
Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability MDR cells strengthened compared their parental cells. However, mechanisms underlying have not been fully elucidated. We found that CD44 and cellular prion protein (PrPc) were both overexpressed (MCF7/Adr H69AR). Subsequently, we chose human cancer cell line MCF7/Adr, which resistant adriamycin, for further research. discovered...
The high prevalence of Helicobacter pylori (H pylori) infection in China results a substantial public health burden. Medical experts have not agreed on the best solution population intervention for this problem. We presented economic evaluation population-based H screen-and-treat strategy preventing gastric cancer, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD).Decision trees Markov models were developed to evaluate cost-effectiveness screening followed by eradication treatment...
Sphingolipid dysregulation is often associated with insulin resistance, while the enzymes controlling sphingolipid metabolism are emerging as therapeutic targets for improving sensitivity. We report herein that sphingosine kinase 2 (SphK2), a key enzyme in catabolism, plays critical role regulation of hepatic signaling and glucose homeostasis both vitro vivo. Hepatocyte-specific Sphk2 knockout mice exhibit pronounced resistance intolerance. Likewise, SphK2-deficient hepatocytes resistant to...
Therapeutic aptamers targeting vascular endothelial growth factor A (VEGFA) have advanced the development of antiangiogenic drugs for treating choroidal neovascularization (CNV) diseases. However, despite FDA approval use in neovascular age-related macular degeneration (nAMD), effective vivo delivery therapeutic is hindered by ocular barriers and rapid degradation biofluids. Here, we demonstrated a microinvasive VEGFA-targeted to fundus using tetrahedral framework nucleic acids (tFNAs). Upon...
To compare the peri-operative and early renal functional outcomes of robot-assisted partial nephrectomy (RAPN) laparoscopic (LPN) for kidney tumours.A total 237 patients fulfilling selection criteria were included, whom 146 91 treated with LPN RAPN, respectively. adjust potential baseline confounders, propensity-score matching was performed. A favourable outcome defined as a warm ischaemia time (WIT) ≤20 min, negative surgical margins, no conversion, Clavien ≥3 complications postoperative...
Helicobacter pylori (H. pylori) infection and its related diseases are substantial public health burden for highly infected areas. Recently, a novel family-based H. control management (FBCM) strategy is introduced prevention control. However, cost-effectiveness has not been evaluated. We conducted this economic evaluation to investigate the of FBCM, screen-and-treat, no-screen strategies in Chinese population.Cost-effectiveness analysis was performed using decision tree Markov model....
BackgroundActivation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all which are crucial for progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed multiple tumours plays a role development, but the underlying mechanisms has not been fully investigated.MethodsWe employed ovarian cervical cancer mouse models detect OVA66 growth, metastasis cells. Immunofluorescence western blot were used...
Obesity is a well-known risk factor for developing endometrial cancer. However, the incidence and survival rate of cancer are associated with ethnicity geographical area. In addition, whether menopausal status in obese women obesity subtypes have not been fully investigated. Here, we investigated effect BMI on Chinese taking into account subtypes.Data 1,127 including body mass index (BMI), age at diagnosis, parity, subtype were collected from largest obstetrics & gynaecology hospital China...
Interplay between cell polarity module Scribble‐Lethal Giant Larvae‐Discs Large 1 (DLG1) and Yes‐associated protein (YAP) appears critical in tumor metastasis. We identified zinc finger 191 (ZNF191) as a metastasis suppressor acting through DLG‐YAP crosstalk hepatocellular carcinoma (HCC). Overexpression of ZNF191 HCC cells impaired motility, while depletion promoted migration vitro vivo triggering YAP signaling. Chromatin immunoprecipitation‐sequencing revealed that specifically bound to...
Purpose . We evaluated the effect of sulforaphane (SFN) treatment on function and changes expression Nrf2‐ARE pathway in bladder rats with outlet obstruction (BOO). Materials Methods A total 18 male Sprague‐Dawley at age 8 weeks were divided into 3 groups (6 each): sham operated group, BOO BOO+SFN group. examined histological alterations oxidative stress markers protein pathway. Results found that SFN could prolong micturition interval increase capacity compliance. However, peak voiding...
Abstract Ovarian cancer poses a significant threat to women’s health, with conventional treatment methods encountering numerous limitations, and the emerging engineered bacterial anti-tumor strategies offer newfound hope for ovarian treatment. In this study, we constructed VNP20009-Abvec-Igκ-MIIP (VM) strain conducted initial assessments of its in vitro growth performance expression capability migration/invasion inhibitory protein (MIIP). Subsequently, ID8 cells mouse models were investigate...
Benign prostatic hyperplasia (BPH), characterized by the non-malignant enlargement of prostate, exhibits a pronounced association with inflammation resulting from androgen receptor (AR) deficiency. Ferroptosis, cell death mechanism triggered iron-dependent lipid peroxidation and closely linked to inflammation, has yet be fully understood in context BPH. Using RNA sequencing, we observed significant elevation taurine-upregulated gene 1 (TUG1) long noncoding (lncRNA) BPH tissues compared...
<i>Background:</i> Multidrug-resistant cancer cells overexpressing P-glycoprotein (P-gp) display variations in invasive and metastatic ability through the upregulation of extracellular matrix metalloproteinase (MMP) inducer (CD147). However, direct linkage between these two proteins is still unclear. <i>Methods:</i> We used immunoprecipitation, immunofluorescence analysis, migration invasion assays, drug sensitivity assay Western blot to measure physical functional...
Abstract The incidence of benign prostatic hyperplasia (BPH) is increasing among obese individuals, but few studies have fully explained the underlying mechanisms. We aimed to elucidate relationship between obesity and BPH. Herein, we show that in epithelial stromal cells, adiponectin exerts multifunctional effects including anti-proliferation, blocking G1/S-phase progression promotion apoptosis via inhibiting MEK-ERK-p90RSK axis. Furthermore, found a high-fat diet (HFD) led deficiency...
Abstract LIM and SH3 protein 1 (LASP1) is a specific focal adhesion that promotes metastasis in variety of tumours. However, its role head neck squamous cell carcinoma (HNSCC) has not been fully validated. The purpose this study was to analyse the interaction LASP1 binding partner HNSCC. expression HSPA1A HNSCC analysed by real‐time PCR Western blot. effects on biology behaviour lines were observed vivo vitro. Co‐immunoprecipitation analysis performed confirm between HSPA1A. highly expressed...
Extracellular vesicles (EVs) have emerged as a unique mediator of interorgan communications, playing important roles in the pathophysiologic process various diseases, including diabetes and other metabolic diseases. Here, we reported that EVs released by steatotic hepatocytes exerted detrimental effect on pancreatic β cells, leading to β-cell apoptosis dysfunction. The was profoundly attributable an up-regulation miR-126a-3p hepatocyte-derived EVs. Accordingly, overexpression promoted,...