A5102793894- Immune cells in cancer
- Autophagy in Disease and Therapy
- Chemokine receptors and signaling
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Caveolin-1 and cellular processes
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Berberine and alkaloids research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Nanoplatforms for cancer theranostics
- Telomeres, Telomerase, and Senescence
- Peptidase Inhibition and Analysis
- Biochemical and Molecular Research
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
University of Kentucky
2019-2025
Markey Cancer Center
2019-2025
Aerospace Center Hospital
2024-2025
Sichuan University
2013-2024
Vanderbilt University
2011-2024
Northeast Forestry University
2024
VA Tennessee Valley Healthcare System
2014-2024
Vanderbilt University Medical Center
2015-2024
Chongqing University of Science and Technology
2024
Guangzhou Medical University
2019-2024
beclin 1, the mammalian homologue of yeast Atg6, is a key autophagy-promoting gene that plays critical role in regulation cell death and survival various types cells. However, recent studies have observed expression 1 altered certain diseases including cancers. The causes underlying aberrant remain largely unknown. We report here microRNAs (miRNAs), class endogenous, 22–24 nucleotide noncoding RNA molecules able to affect stability translation mRNA, may represent previously unrecognized...
Abstract Invasion and metastases of cancer cells the development resistance to anticancer therapies are main causes morbidity mortality from cancer. For more than two decades, these important but not clearly related aspects in biology have been extensively studied. Specifically, P-glycoprotein CD44 characterized known be determinants multidrug (MDR) metastases. Despite this body knowledge, few reports linked phenotypes only recently there reasons suspect a direct connection. In report, we...
Abstract Purpose: Constitutive activation of inhibitor κB kinase (IKK) confers melanoma resistance to apoptosis and chemotherapy. Whether IKK is able serve as a therapeutic target in unknown. We explored the possibility exploiting by using BMS-345541, novel compound with highly selective IKKβ inhibitory activity, trigger cell apoptosis. Experimental Design: Three human lines (SK-MEL-5, Hs 294T, A375), all which have high constitutive activities, served vitro vivo models for treatment...
Gefitinib, a small molecule inhibitor of the epidermal growth factor receptor tyrosine kinase, has been shown to induce autophagy as well apoptosis in tumor cells. Yet, how use and improve therapeutic efficacy this drug against cancer remains be explored. We reported here that MK-2206, potent allosteric Akt currently phase I trials patients with solid tumors, could reinforce cytocidal effect gefitinib glioma. found cotreatment MK-2206 increased cytotoxicity glioma cells, CompuSyn...
Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through apoptosis autophagy were modulated in cells subjected inhibition by MK-2206, first allosteric small molecule inhibitor enter clinical development. human glioma cells, MK-2206 or siRNA-mediated attenuation strongly activated whereas silencing eukaryotic elongation factor-2 (eEF-2) kinase, a...
Abstract Purpose: Metastatic breast cancers continue to elude current therapeutic strategies, including those utilizing PI3K inhibitors. Given the prominent role of PI3Kα,β in tumor growth and PI3Kγ,δ immune cell function, we sought determine whether inhibition altered antitumor immunity. Experimental Design: The effect on growth, metastasis, response was characterized mouse models orthotopic implants 4T1 or PyMT mammary tumors into syngeneic PI3Kγ-null mice, patient-derived cancer...
The study aims to elucidate the anti-inflammatory effect and mechanism of Roseburia intestinalis (R. intestinalis) in Crohn's disease (CD).16S-rRNA genome sequencing technique is used detect characteristics intestinal microbiota untreated CD patients healthy controls. Then investigates effects R. on activity index score, pathology, differentiation Treg cells, expressions Thymic stromal lymphopoietin (TSLP), TGF-β IL-10 by using TNBS colitis models. At cellular level, uses LPS stimulate...
CDK4/6 inhibition becomes effective in preclinical models of melanoma when combined with MDM2 antagonism.
Abstract In this study, it is found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1 (DDIT4‐AS1), highly expressed in triple‐negative breast cancer (TNBC) cell lines and tissues due to H3K27 acetylation promoter region, promotes proliferation, migration, invasion of TNBC cells via activating autophagy. Mechanistically, shown DDIT4‐AS1 induces autophagy by stabilizing DDIT4 mRNA recruiting RNA binding protein AUF1 promoting interaction between AUF1, thereby inhibiting mTOR...
The therapy of solid tumors is often hindered by the compact and rigid tumoral extracellular matrix (TECM). Precise reduction TECM hyaluronidase (HAase) in combination with nanotechnology promising for tumor therapeutics, yet remains an enormous challenge. Inspired treatment iron poisoning, here a remotely unwrapping strategy proposed metal-polyphenol-packaged HAase (named PPFH) sequentially injecting PPFH clinically used iron-chelator deferoxamine (DFO). situ dynamic disassembly can be...
Topoisomerase I (Top I)-DNA covalent complexes represent a unique type of DNA lesion whose repair and processing remain unclear. In this study, we show that Top I-DNA transiently arrest RNA transcription in normal nontransformed cells. Arrest is coupled to activation proteasomal degradation the large subunit polymerase II. Recovery occurs gradually depends on both functional transcription-coupled (TCR). These results suggest elongation complex by triggers 26S proteasome-mediated signaling...
Abstract Elongation factor-2 kinase (eEF-2 kinase), also known as Ca2+/calmodulin–dependent III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity eEF-2 is increased in glioblastoma and other malignancies, yet its role neoplasia uncertain. Recent evidence suggests that autophagy plays an important oncogenesis this can be regulated mammalian target rapamycin (mTOR). Because lies downstream mTOR, we studied using human cell lines. Knockdown RNA...