A5100602529- Neuroinflammation and Neurodegeneration Mechanisms
- Liver physiology and pathology
- Nitric Oxide and Endothelin Effects
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Signaling Pathways in Disease
- Reproductive System and Pregnancy
- Polyamine Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Endometriosis Research and Treatment
- interferon and immune responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Respiratory Support and Mechanisms
- Alzheimer's disease research and treatments
- Pleural and Pulmonary Diseases
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Nuclear Structure and Function
- Autophagy in Disease and Therapy
- Synthesis and Reactions of Organic Compounds
- Pharmacological Receptor Mechanisms and Effects
China Pharmaceutical University
2001-2024
Chengdu University of Traditional Chinese Medicine
2024
China-Japan Friendship Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Emory University
2018
Soochow University
2011
Pennsylvania State University
2011
Central South University
2005-2010
Xiangya Hospital Central South University
2010
University of Ottawa
2009
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark the amyotrophic lateral sclerosis frontotemporal dementia disease spectrum (ALS/FTD). However, composition aggregates their contribution to process remain unknown. Here we used proximity-dependent biotin identification (BioID) interrogate interactome detergent-insoluble TDP-43 found them enriched for components nuclear pore complex nucleocytoplasmic transport...
Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through apoptosis autophagy were modulated in cells subjected inhibition by MK-2206, first allosteric small molecule inhibitor enter clinical development. human glioma cells, MK-2206 or siRNA-mediated attenuation strongly activated whereas silencing eukaryotic elongation factor-2 (eEF-2) kinase, a...
Abstract DNA damage is a critical component of neuronal death underlying neurodegenerative diseases and injury. Neuronal evoked by characterized inappropriate activation multiple cell cycle components. However, the mechanism regulating this not fully understood. We demonstrated previously that division (Cdc) 25A phosphatase mediates cyclin‐dependent kinases damaging agent camptothecin. also showed Cdc25A blocked constitutive checkpoint kinase 1 activity under basal conditions in neurons....
Objective To investigate the expression of 5-lipoxygenase (5-LOX) in endometriosis and analyze relationship 5-LOX angionesis endometriosis. Methods Immunochemical method was used to determine 5-LOX, VEGF, value MVD ectopic endometrium (ec-topic group) eutopic (eutopic 32 patients with EMs ( control 25 without EMs. Result The expressions VECF groups were 0. 43 ± 0.09,0. 39 ±0.07 0.40 0.09, respectively, which higher than that group group. VEGF 35 08, 0.30 06 33 P <0.05). In group, stage...