A5082461403- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Cancer therapeutics and mechanisms
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Fibroblast Growth Factor Research
- PI3K/AKT/mTOR signaling in cancer
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Bioactive Compounds and Antitumor Agents
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Diet and metabolism studies
- Phagocytosis and Immune Regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Wnt/β-catenin signaling in development and cancer
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
Xiamen University
2009-2025
General Hospital of Shenyang Military Region
2025
Shanghai Jiao Tong University
2024
Shanghai Ninth People's Hospital
2024
Sichuan University
2023-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Taizhou People's Hospital
2020
Nantong University
2020
Zhejiang Hospital
2019
Tianjin Medical University
2015-2018
Background: More than one-fifth of the world’s population consumes Chinese cuisines regularly, but no evidence-based healthy diets fitting food culture are available for implementation. Methods: A multicenter, patient- and outcome assessor–blind, randomized feeding trial was conducted among 265 participants with 130 to 159 mm Hg baseline systolic blood pressure (SBP) 4 major (Shangdong, Huaiyang, Cantonese, Szechuan). After a 7-day run-in period on control diet matching usual local diets,...
UHRF1, an epigenetic factor, is implicated in various cellular processes of tumorigenesis. However, the modulation UHRF1 expression human bladder cancer at post-transcriptional levels remains unclear. Here, we report that miR-124 suppresses to affect progression through competitive binding same region its 3'-UTR. We show compared with corresponding normal tissues, upregulated and downregulated demonstrating inverse correlation UHRF1. Quantitative PCR western blot assay demonstrated...
Significance Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Most studies have focused on epigenetic gene-silencing events; therefore, the mechanism that promotes activation HCC is not well established. We identify an whereby menin Yes-associated protein (Yap1) transcription, which a poor prognosis for patients. Substantial overexpression of menin–mixed-lineage leukemia complex increased histone 3 lysine 4 trimethylation...
Alterations of polycomb group (PcG) genes directly modulate the trimethylation histone H3 lysine 27 (H3K27me3) and may thus affect epigenome hepatocellular carcinoma (HCC), which is crucial for controlling HCC cell phenotype. However, extent downstream regulation by PcGs in not well defined. Using cDNA microarray analysis, we found that target gene network contains well-established genes, such as cyclin-dependent kinase inhibitors (CDKN2A), were previously undescribed their PcG, including...
Previous studies reported that miR-433 exerts function widely in human tumorigenesis and development. Here, we further investigate the potential role of glioma. Quantitative real-time PCR demonstrated miR-433-3p miR-433-5p were low expressed glioma tissues cell lines. Functional suggested overexpression suppressed proliferation, induced apoptosis inhibited invasion migration cells. But growth metastasis cells not significantly influenced by miR-433-5p. In a xenograft model, also showed had...
The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, biological importance of this NE-type lung cancer vivo remains unclear. Here, we established an ATII-specific KrasG12D/+/Men1-/- driven genetically engineered mouse model and show deficiency menin results accumulation DNA damage antagonizes oncogenic Kras-induced senescence epithelial-to-mesenchymal transition during tumorigenesis. loss expression...
Menin is a scaffold protein encoded by the Men1 gene, and it interacts with variety of chromatin regulators to activate or repress cellular processes. The potential importance menin in immune regulation remains unclear. Here, we report that myeloid deletion results development spontaneous pulmonary alveolar proteinosis (PAP). This strongly correlated impaired macrophages (AM) through inactivation granulocyte-macrophage colony-stimulating factor (GM-CSF/CSF2) pathway caused deficiency....
Abstract Background Uterine corpus endometrial carcinoma (UCEC) is one of the most frequent female genital malignant tumors. Targeting DNA damage and cell apoptosis are regarded as effective ways for UCEC therapy. Celastrol a natural anti-cancer product from Celastraceae plant family, while its role in has not been investigated. Methods lines Ishikawa HEC-1-A were applied treated with different concentrations Celastrol. The appropriate nontoxic used subsequent experiments. Functional...
Abstract Lysosome-mediated autophagy (including mitophagy) is crucial for cell survival and homeostasis. Although the mechanisms of lysosome activation during stress are well recognized, epigenetic regulation lysosomal gene expression remains largely unexplored. Menin, encoded by MEN1 gene, a chromatin-related protein that widely involved in transcription via histone modifications. Here, we report menin regulates specific genes, such as CTSB , CTSE TFE3 through MLL-mediated H3K4me3...
Tumor suppressor menin, the product of MEN1 gene, plays a key role in controlling histone 3 lysine 4 trimethylation (H3K4me3) and gene transcription, which can regulate proliferation, apoptosis, differentiation. However, little is known as to whether menin controls expression cell proliferation survival via regulating Polycomb group (PcG) protein complex/H3K27me3. Here we show that specifically represses transcription factor Paired box 2 (Pax2) through PcG-mediated H3K27me3 Wilms tumor...
Objective To clarify the role of long non-coding RNA (lncRNA) SND1-IT1 in accelerating proliferative and migratory abilities osteosarcoma (OS) via sponging miRNA-665 to upregulate POU2F1. Patients methods The relative level OS tissues was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). target gene predicted bioinformatics verified Dual-Luciferase reporter assay. Similarly, identified. Correlation among SND1-IT1, POU2F1 evaluated through linear regression test....
Hypertrophic scar (HS) and keloid (KD) are common dermal fibroproliferative growth caused by pathological wound healing. HS's prevalence is currently undetermined in China. Though it primarily occurs dark-skinned individuals, KD can develop all races, its among Chinese people poorly documented.To explore the present epidemiological status of them college students.We conducted a university-based cross-sectional study at one university Fujian, A total 1785 participants aged 16-34 years (mean...
Benign prostatic hyperplasia (BPH), characterized by the non-malignant enlargement of prostate, exhibits a pronounced association with inflammation resulting from androgen receptor (AR) deficiency. Ferroptosis, cell death mechanism triggered iron-dependent lipid peroxidation and closely linked to inflammation, has yet be fully understood in context BPH. Using RNA sequencing, we observed significant elevation taurine-upregulated gene 1 (TUG1) long noncoding (lncRNA) BPH tissues compared...
Growth inhibition in the Chinese hamster cell line V79 and human lymphoid Raji induction of sister chromatid exchange(s) (SCE) cells after treatment with six anticancer drugs [harringtonine (HRT), homoharringtonine (HHRT), camptothecin (CPT), hydroxycamptothecin (HCPT), lycobetaine (LBT), oxalysine (OXL)] developed People's Republic China were studied. OXL is a new antibiotic; all other are plant extracts. All caused dose-dependent growth both types, as evidenced by decreases plating...
Abstract Menin is necessary for the formation of menin/mixed lineage leukemia (MLL) complex and recruited directly to chromatin. an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated role MLL menin-regulated tumorigenesis. Ablation suppressed KrasG12D-induced tumorigenesis a genetically engineered mouse model. deficiency decreased histone H3 lysine 4 trimethylation (H3K4me3) subsequently expression Ras protein-specific guanine...
Substantial genetic evidence suggests that chromosome 11q is involved in regulating initiation and progression of malignant melanomas. Mutations the MEN1 gene, located 11q13, predispose individuals to multiple endocrine neoplasia type 1 (MEN1) familial syndrome. patients develop primary melanoma, suggesting a potential link between syndrome development melanomas, but precise molecular mechanism poorly understood. Here we show gene suppresses phenotypes melanoma cells through signalling...
Fms-related tyrosine kinase 1 (Flt1), the receptor of VEGF/PIGF, is associated with cancer angiogenesis and tumorigenesis. Although high expression Flt1 in glioma identified, its regulatory mechanism remains unclear. In present study, we demonstrate that miR‑139‑5p inhibits mediated by binding 3' untranslated region (3'UTR) to regulate progression human glioma. We found was downregulated tissues compared normal brain whereas a converse level observed. Additionally proved directly integrated...
Transforming growth factor-beta (TGF-β) functions in fibrogenesis as a profibrotic mediator, regulating cell proliferation, migration, apoptosis and collagen production of fibroblasts. microRNA-155 (miR-155), the expression which has been related to bleomycin-induced idiopathic pulmonary fibrosis, involved TGF-β induced epithelial-mesenchymal transition. Here, we found that miR-155 was decreased human fibroblasts by treatment. We overexpressed investigate functional impact on TGF-β-induced...
To establish a universally applicable logistic risk prediction model for diabetes mellitus type 2 (T2DM) in the middle-aged and elderly populations based on results of Meta-analysis, to validate confirm efficacy using follow-up data medical check-ups National Basic Public Health Service.
Expression of microRNA(miR)-142-3p has been implicated to be associated with several cancers, whereas its function in bladder cancer (BC) remains unknown. The present study aimed explore the correlation between expression miR-142-3p and proliferation, migration invasion cells by activating Rac1. qRT-PCR was used measure miR-142- 3p tissues cell lines. RNA transfection silence accelerate cells. CCK-8 trans-well assays were detect before after transfection. direct interaction Rac1 demonstrated...