A5007916150- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Microbial Natural Products and Biosynthesis
- Genomics and Chromatin Dynamics
- Plant Pathogens and Fungal Diseases
- Traditional Chinese Medicine Studies
- Traditional and Medicinal Uses of Annonaceae
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Traditional Chinese Medicine Analysis
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Protein Degradation and Inhibitors
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Hepatitis C virus research
- Chromatography in Natural Products
- Phytochemistry and Bioactive Compounds
- Radiomics and Machine Learning in Medical Imaging
- Dermatologic Treatments and Research
- Hippo pathway signaling and YAP/TAZ
- Bioactive Natural Diterpenoids Research
- Calcium signaling and nucleotide metabolism
Sun Yat-sen University
2024
Xiamen University
2008-2023
Anhui Medical University
2021
Shanghai University of Traditional Chinese Medicine
2021
Sichuan University
2017-2020
West China Hospital of Sichuan University
2017-2020
University of Science and Technology of China
2020
College of Medical Sciences
2013
Zhongshan Hospital of Xiamen University
2012
Significance Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Most studies have focused on epigenetic gene-silencing events; therefore, the mechanism that promotes activation HCC is not well established. We identify an whereby menin Yes-associated protein (Yap1) transcription, which a poor prognosis for patients. Substantial overexpression of menin–mixed-lineage leukemia complex increased histone 3 lysine 4 trimethylation...
Alterations of polycomb group (PcG) genes directly modulate the trimethylation histone H3 lysine 27 (H3K27me3) and may thus affect epigenome hepatocellular carcinoma (HCC), which is crucial for controlling HCC cell phenotype. However, extent downstream regulation by PcGs in not well defined. Using cDNA microarray analysis, we found that target gene network contains well-established genes, such as cyclin-dependent kinase inhibitors (CDKN2A), were previously undescribed their PcG, including...
The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, biological importance of this NE-type lung cancer vivo remains unclear. Here, we established an ATII-specific KrasG12D/+/Men1-/- driven genetically engineered mouse model and show deficiency menin results accumulation DNA damage antagonizes oncogenic Kras-induced senescence epithelial-to-mesenchymal transition during tumorigenesis. loss expression...
Although the genotype–phenotype for familial medullary thyroid carcinoma (FMTC) is well studied, only few low susceptibility risk loci were identified non‐medullary (FNMTC). The aim of this study to screen and identify high‐penetrate genes FNMTC. A total 34 families with more than two first‐degree relatives diagnosed as papillary cancer without other syndrome recruited. Whole exome target gene sequencing performed candidate variants. These variants screened analyzed ESP6500, ExAC, 1000...
Cervical cancer is induced by persistent infections with high‐risk human papillomaviruses (HPVs), which produce the early protein 6 of HPVs (E6)/E7 that involved in cell transformation interacting several oncoproteins or tumor suppressors. However, role noncoding RNA mediating pathogenesis cervical remains unclear. Here, we report novel signal transducer and activator transcription 3 (STAT3)‐microRNA‐223‐3p (miR‐223)‐TGFBR3/HMGCS1 axis regulated E6 controls carcinogenesis. miR‐223 was highly...
Tumor suppressor menin, the product of MEN1 gene, plays a key role in controlling histone 3 lysine 4 trimethylation (H3K4me3) and gene transcription, which can regulate proliferation, apoptosis, differentiation. However, little is known as to whether menin controls expression cell proliferation survival via regulating Polycomb group (PcG) protein complex/H3K27me3. Here we show that specifically represses transcription factor Paired box 2 (Pax2) through PcG-mediated H3K27me3 Wilms tumor...
Abstract Menin is necessary for the formation of menin/mixed lineage leukemia (MLL) complex and recruited directly to chromatin. an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated role MLL menin-regulated tumorigenesis. Ablation suppressed KrasG12D-induced tumorigenesis a genetically engineered mouse model. deficiency decreased histone H3 lysine 4 trimethylation (H3K4me3) subsequently expression Ras protein-specific guanine...
Abstract From the fermentation extract of Xylarialean sp. A45, an endophytic fungus Annona squamosa L., three new triterpenes, namely xylariacins A–C ( 1 – 3 , resp.) were obtained. Their structures determined by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments HR‐ESI‐Q‐TOF mass spectrometry. The in vitro cytotoxic activities compounds tested against human tumor cell line HepG2, these showed modest activity.
One new metabolite 3,7-dimethyl-9-(-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)nona-1,6-dien-3-ol, together with nine known compounds, were isolated from the strain Xylaria sp., an endophytic fungus of Taxus mairei. Their structures deduced 1D and 2D NMR data. In vitro cytotoxicity antibacterial activity these compounds evaluated. Some them exhibited substantial activity.
Abstract Background Type 2 diabetes mellitus (T2DM) increases the risk of liver cancer among people living with hepatitis B virus (HBV). Our study aimed to estimate global burden and trends attributable comorbid T2DM HBV from 1990 2019. Methods We calculated population fractions (PAFs) HBV-related cancer. applied PAFs derived Global Burden Disease (GBD) 2019 database obtain HBV–T2DM comorbidity. The prevalence, disability-adjusted life year (DALY), deaths comorbidity were assessed at global,...
Local or distant relapse is the key event for overall survival of early-stage breast cancer after initial surgery. A small subset cells, which share similar properties with normal stem has been proven to resist clinical therapy contributing recurrence.In this study, we aimed develop a prognostic model predict recurrence based on prevalence cells (BCSCs) in cancer. Immunohistochemistry and dual-immunohistochemistry were performed quantify patients. The performance Cox proportional hazard...
Four new metabolites, named pyrenochaetamide A (1), pyrenochaetolide (2), pyrenochaetoxy (3) and B (4), together with five known compounds (5–9), were isolated from strain Pyrenochaeta sp. B36, an endophytic fungus of Annona squamosa L. Their structures elucidated by spectroscopic analyses including 1D- 2D-NMR (HMQC, HMBC, 1H–1H COSY NOESY) HRFT-MS. The cytotoxic activities these evaluated some them showed substantial effect.
Ductal carcinoma in situ (DCIS) contributes to 20%-30% of newly diagnosed cases breast cancer China. Although the cancer-specific mortality DCIS is extremely low, a small proportion patients still show relapse or metastasis, leading poor prognosis. Little known about molecular mechanism for partly due limited number prognosis patients. This study analyzed clinicopathological features and screened key microRNAs (miRNAs) contributing local distant recurrence.The were evaluated survival...
Due to the limitation of science and technology in ancient times, traditional Chinese medicines (TCMs) could have prepared only dosage forms, such as pills, powders, ointments pellets. Though studies on multi-component TCMs become one major development orientations TCM, druggability their preparations has always been neglected. On basis two key difficulties--the integration TCM theory well evaluation druggability, essay proposes methods technologies that can be adopted preparations,...
Chemotherapy and targeted therapies are increasingly used as conventional means to control tumor growth prolong survival. Patient treated with anti-neoplastic agents experience severe side effects, especially those cytotoxic chemotherapies. Exploring chemo less effects is the hot spot of anticancer research. In this study, three azaphilone derivatives (chaetoviridin A (1), chaetoviridin E (2) chaetomugilin D (3)) were isolated from endophyte plant Anoectochilus roxburghii (Wall.) Lindl,...