A5100389961- Dietary Effects on Health
- Gut microbiota and health
- Immune cells in cancer
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- T-cell and B-cell Immunology
- Probiotics and Fermented Foods
- Oral health in cancer treatment
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- Ginseng Biological Effects and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Childhood Cancer Survivors' Quality of Life
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Digestive system and related health
- Autophagy in Disease and Therapy
Xiamen University
2025
Zhongshan Hospital
2025
Sun Yat-sen University
2025
Guangzhou University of Chinese Medicine
2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Beijing University of Chinese Medicine
2024
Second Affiliated Hospital of Nanchang University
2019-2024
Nanchang University
2014-2024
Shenzhen Bao'an District People's Hospital
2024
Stem cell aging underlies aging-associated disorders, such as steeply increased incidences of tumors and impaired regeneration capacity upon stress. However, whether how the intestinal stem cells age remains largely unknown. Here we show that derived from 24-month-old mice hardly form typical organoids with crypt-villus structures, but rather mainly big, rounded cysts devoid differentiated types, which mimics culturing heterozygous APC-deficient APCmin mouse line. Further analysis showed...
Menin is a scaffold protein encoded by the Men1 gene, and it interacts with variety of chromatin regulators to activate or repress cellular processes. The potential importance menin in immune regulation remains unclear. Here, we report that myeloid deletion results development spontaneous pulmonary alveolar proteinosis (PAP). This strongly correlated impaired macrophages (AM) through inactivation granulocyte-macrophage colony-stimulating factor (GM-CSF/CSF2) pathway caused deficiency....
Epithelial–mesenchymal transition (EMT) is a crucial pathological process in the pathogenesis of fibrosis. 3,5,6,7,8,3′,4′-hepmethoxyflavone (HMF), main active ingredient extracted from Chinese herb Breynia fruticosa (L.) Hook. f., has been shown to have beneficial effects on regulating apoptosis and inhibiting collagen deposition. However, it remains unclear whether how HMF alleviates transforming growth factor-β1 (TGF-β1)-induced EMT. The objective this study was investigate impact...
The world's aging population is growing rapidly. Incidences of multiple pathologies, such as abdominal obesity, cardiovascular and cerebrovascular diseases, type 2 diabetes, malignant neoplasms, increase sharply with age. Aged individuals possess a significantly shifted composition gut microbiota, which suggested to play important roles in associated pathologies. Whether the existing structural microbiota aged populations can be reverted non-pharmacologically has not been studied so far....
Methotrexate (MTX) is a typical chemotherapeutic drug that widely used in the treatment of various malignant diseases as well autoimmune diseases, with gastrointestinal toxicity being its most prominent complication which could have significant effect on prognosis patients. Yet effective ways to alleviate such complications remains be explored. Here we show 30% dietary restriction (DR) for 2 weeks dramatically increased survival rate 2-month-old female mice after lethal-dose MTX exposure. DR...
Hepatitis B virus (HBV) infection is a major risk factor which can lead to development of hepatocellular carcinoma (HCC). In this study, we aimed explore the effects toll-like receptor 4 (TLR4) downregulation on growth and survival HBV-related HCC cells examine molecular mechanisms been involved.The expression levels TLR4 were examined in panel cell lines (HepG2, SMMC7721, Huh7, HepG2.2.15 Hep3B). The proliferation, apoptosis, tumorigenicity determined. multiple signaling pathways also...
Abstract Currently, the world's aging population is expanding rapidly, leading to a rise in aged hematopoietic cell transplantation (HCT) recipients and donors. However, age of donors negatively related prognosis after due functional decline stem cells (HSCs) during aging. Previously, we showed that an early‐onset dietary restriction (DR) significantly retards early HSCs. effects mid‐onset DR on HSCs remain unknown. In current study, performed 30% 15‐ 18‐month‐old mice (equivalent 50–60...
Ultraviolet B (UVB) radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic disorders. Dietary restriction (DR) is a well-known regimen that can retard aging-associated pathologies, and shown by us others it significantly inhibit inflammation under various conditions, including in both undisturbed stressed settings. It unknown whether DR could act as nonpharmacological factor protect skin against UVB-induced damage. In this study, we...
Dietary restriction (DR) is one of the most robust interventions shown to extend health-span and remains on forefront anti-aging intervention studies, though conflicting results have been its effect lifespan both in rodents primates. The severe inhibitory effects lymphoid lineage by DR major negative downsides which reduces overall beneficial organismal health. Yet, underlying mechanism how suppresses system be explored. Here, we show that antibiotic ablation gut microbiota significantly...
Hematopoietic cell transplantation (HCT) is an important therapy for many hematological malignancies as well some non-malignant diseases. Post-transplant hematopoiesis affected by multiple factors, and the mechanisms of delayed post-transplant remain poorly understood. Patients undergoing HCT often suffer from significantly reduced food intake due to complications induced preconditioning treatments. Here, we used a dietary restriction (DR) mouse model study effect reduction on hematopoietic...
Introduction Bladder cancer (BCa) is a common malignancy in the urinary tract. It has high recurrence rates and often requires microscopic examination, which presents significant challenges clinical treatment. Previous research shown that circular TAF4B (circTAF4B) significantly upregulated BCa associated with poor prognosis. However, specific targets molecular mechanisms by circTAF4B functions are still not well - understood. Methods In this study, an RNA pull down assay mass spectrometry...
Abstract Aging is characterized by the accumulation of DNA damage and a decrease in stem cell functionality, yet molecular mechanisms that limit maintenance cells response to remain be delineated. Here we show mouse models leads transient over-activation Wnt signaling hematopoietic (HSCs), high activity canonical Wnt/β-catenin sensitizes HSCs induced X-irradiation which results preferential with low levels signaling. The study shows genetic or chemical activation enhances radiosensitivity...