A5101859329- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Effects of Radiation Exposure
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Pediatric Pain Management Techniques
- RNA modifications and cancer
- CNS Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis B Virus Studies
- Microtubule and mitosis dynamics
- Pain Management and Placebo Effect
- Lung Cancer Diagnosis and Treatment
- Pain Management and Opioid Use
- Cancer-related molecular mechanisms research
Nanchang University
2013-2025
Second Affiliated Hospital of Nanchang University
2013-2025
Jiujiang First People's Hospital
2024
Tianjin Medical University Cancer Institute and Hospital
2024
First Affiliated Hospital of Jinan University
2024
Shenzhen Second People's Hospital
2022
Jiangxi Provincial Cancer Hospital
2019
Shanghai University of Traditional Chinese Medicine
2011
Second Military Medical University
2011
Yueyang Hospital
2011
Abstract Purpose: Mitogen-activated protein kinase 4 (MAP4K4) is overexpressed in many types of cancer. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function hepatocellular carcinoma (HCC). Experimental Design: MAP4K4 was examined 20 fresh HCCs corresponding nontumor liver tissues. Immunohistochemistry for performed on additional 400 HCCs, which 305 (76%) were positive hepatitis B surface antigens. The significance analyzed. downregulation HCC...
Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients. These include exon 14 skipping mutations (MET skipping), amplifications, point (primarily kinase domain mutations), and protein overexpression. Accurate identification these appropriate selection patient populations targeted...
Hepatitis B virus (HBV) infection is a major risk factor which can lead to development of hepatocellular carcinoma (HCC). In this study, we aimed explore the effects toll-like receptor 4 (TLR4) downregulation on growth and survival HBV-related HCC cells examine molecular mechanisms been involved.The expression levels TLR4 were examined in panel cell lines (HepG2, SMMC7721, Huh7, HepG2.2.15 Hep3B). The proliferation, apoptosis, tumorigenicity determined. multiple signaling pathways also...
In order to prepare functional Au nanoparticles with low toxicity and high antitumor properties, we have used fruit waste (banana peel) synthesize a new dendrite-shaped gold nanoparticle it for the treatment of tumors.Dendrite-shaped (Au-dendrite) was synthesized through facile hydrothermal process. The banana peel as both reducing agent protective chloroauric acid obtain Au-dendrite. safety assessment Au-dendrite conducted by H&E staining mouse's eyelid skin CCK-8 assay. effects were...
White adipose tissue wasting plays a critical role in the development and progression of cancer cachexia. However, mechanism behind loss remains ill-defined. In this study, we found that cell-derived exosomes highly expressed miR-425-3p. Administration significantly inhibited proliferation differentiation human preadipocytes-viscereal (HPA-v) cells. mature adipocytes, activated cAMP/PKA signalling lipophagy, leading to adipocyte lipolysis browning white adipocytes. These exosomes-induced...
Small molecular inhibitors or drugs targeting specific alterations are widely used in clinic cancer therapy. Despite the success of targeted therapy, development drug resistance remains a challenging problem. Identifying mechanisms for therapy is an area intense investigation, and recent evidence indicates that cellular polyploidy may be involved. Here, we demonstrate cell cycle kinase inhibitor, Oxindole-1 (Ox-1), induces mitotic slippage, causing resistant acute myeloid leukemia (AML)...
Extranodal natural killer/T-cell lymphoma (NKTCL), nasal type, is an aggressive malignancy with poor prognosis. Currently, there no recommended standard therapy for relapsed NKTCL. A 37-year-old woman lymphadenopathy was diagnosed NKTCL by biopsy of enlarged lymph node on the right side her neck. Enhanced computed tomography revealed metastasis. For this patient, we performed continuous chemotherapy followed radiotherapy; however, nodule showed metastases in lower limbs 3 months after...
Abstract Background: D3S-001 is a second-generation (2G) GDP-bound KRAS G12C inhibitor (G12Ci). Its high covalent potency and rapid target engagement kinetics correlated with robust anti-tumor activity preclinically translated into promising clinical in phase 1 first-in-human trial (FIH). Here we report data from FIH (NCT05410145). Methods: was administered as monotherapy to patients (pts) mutated advanced solid tumors at 6 planned dose levels (50-900mg QD) 3 countries. The key objectives...
Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene are being approved clinical application. At present, tyrosine receptor kinase (TRK) inhibitors neurotrophic (NTRK) among the first "tumor agnostic" pan-cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy same time, several second-generation designed to overcome first-generation drug resistance undergoing development. Due rarity...
Derlin-1 is involved in the elimination of misfolded proteins and has been implicated progression human cancers. However, its prognostic value biological function breast cancer remain unknown. Here, we show that overexpressed exhibits oncogenic activities via interaction with UBE2C. Increased expression correlated lymph node metastasis, advanced clinical stage, unfavorable overall survival two cohorts containing over 1,000 patients. Multivariate analyses by Cox regression model suggest an...
We explored the role and mechanism of circular RNAcircNRD1 in gastric cancer (GC) progression, aiming to identify new bio-markers for treatment prognosis GC patients. The RNA expression was examined by reverse transcription-quantitative polymerase chain reaction. Cell proliferation, migration invasion were analyzed 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 5-ethynyl-2'-deoxyuridine (EdU) incorporation scratch assay transwell assay. Western blot conducted...
In this study, we aimed to investigate the expression and function of interleukin-4 receptor (IL-4R) in hepatocellular carcinoma (HCC).We collected 40 pairs human HCC adjacent normal tissue specimens examined levels IL-4R. After IL-4R knockdown cell lines, proliferation invasion ability were examined. Cell cycle apoptosis analyzed by flow cytometry. The activity multiple signaling pathways was Western blot.IL-4R overexpressed tumors compared with control tissues associated tumor...
With the inspiration of shape loquat fruit, here, we developed a similarly shaped Janus carrier. This peculiar gold rod-partially exposed structure not only significantly increased drug loading capability but also improved its infrared response efficiency. A better effect drug-photothermal treatment thus could be realized. aid an external 3D printed guiding device, this carrier accurately reach different affected areas. The subsequent triggered multiple tumor therapy, thus, conducted in...
e21123 Background: Upregulation of CD73 results in the adenosine overproduction, which suppresses immune responses tumoral microenvironment. Uliledlimab (ULI), a differentiated anti-CD73 antibody, inhibits generation non-competitive manner and tumor growth when combined with PD-(L)1 inhibitor. Methods: The dose-escalation dose expansion phase I/II study (NCT04322006) was designed to evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD), preliminary efficacy ULI alone, or toripalimab...
Abstract Background Early screening and diagnosis of radiation‐induced heart disease (RIHD) is difficult in patients with chest radiation exposure. sST‐2 involved myocardial stress or injury. We evaluated the relationship between dose parameters changes malignant tumor who received radiation. Methods prospectively collected thoracic malignancy cancer had radiotherapy. Heart dosimetry were extracted from treatment planning system. was measured at baseline, middle stage, after radiotherapy...
Abstract LPCAT1 acts as an oncogene in a variety of cancers, but its effect on lung squamous cell carcinoma (LUSC) has not been reported. This study aimed to determine the prognostic value by bioinformatics analyses and confirm LUSC functions vitro experiments. The expression data clinical information were obtained from public database. was evaluated Kaplan-Meier curves, nomogram analysis, Cox regression analyses. relationships immune features also estimated. Then, expressions PTEN/Akt...