A5100732273- Bone Metabolism and Diseases
- Diet and metabolism studies
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Curcumin's Biomedical Applications
- Bone health and osteoporosis research
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Urinary Bladder and Prostate Research
- Bipolar Disorder and Treatment
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Kruppel-like factors research
- Family Caregiving in Mental Illness
- Ovarian function and disorders
- Skin Protection and Aging
- Cancer-related gene regulation
- Gut microbiota and health
- Inflammasome and immune disorders
- Medicinal Plant Pharmacodynamics Research
- Clostridium difficile and Clostridium perfringens research
- Plant Toxicity and Pharmacological Properties
- Pharmacological Effects of Natural Compounds
- Bone and Joint Diseases
Air Force Medical University
2017-2025
Chengdu Medical College
2025
Sichuan University
2015-2016
FHNW University of Applied Sciences and Arts
2016
Luoyang Central Hospital Affiliated to Zhengzhou University
2011
Background: More than one-fifth of the world’s population consumes Chinese cuisines regularly, but no evidence-based healthy diets fitting food culture are available for implementation. Methods: A multicenter, patient- and outcome assessor–blind, randomized feeding trial was conducted among 265 participants with 130 to 159 mm Hg baseline systolic blood pressure (SBP) 4 major (Shangdong, Huaiyang, Cantonese, Szechuan). After a 7-day run-in period on control diet matching usual local diets,...
Depression is a frequent and serious comorbidity associated with diabetes which adversely affects prognosis quality of life. Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used in the treatment diabetes, are reported to exert neuroprotective effects central nervous system. Thus, we aim evaluate whether GLP-1R agonist exendin-4 (EX-4) could alleviate depression-like behaviors diabetic mice explore its underlying mechanism. The antidepressant EX-4 were evaluated using behavioral...
Abstract The human gut, with a complex community of microbes, is essential for maintaining overall health. This gut microbiota engages in two‐way communication the central nervous system, collectively known as microbiota−brain axis. Alterations have been associated various neurological disorders, and disruptions to blood–brain barrier (BBB) may be crucial, though exact mechanisms remain unknown. In current study, we investigated impacts short‐chain fatty acids (SCFAs) on integrity BBB, which...
The purpose of the study was to determine roles interleukin-6 (IL6) in fat and bone communication. Male wild-type (WT) mice IL6 knockout (IL6(-/-)) were fed with either regular diet (RD) or high-fat (HFD) for 12 weeks. Bone mass microstructure evaluated by micro-computed tomography. Gene expression related lipid metabolisms assayed real-time quantitative polymerase chain reaction. marrow cells from both genotypes induced differentiate into osteoblasts osteoclasts, treated palmitic acid (PA)....
Hormone therapy (HT) is reported to be deficient in improving learning and memory older postmenopausal women according recent clinical studies; however, the reason for failure unknown. A "window of opportunity" estrogen treatment proposed explain this deficiency. Here, we found that facilitation extinction long-term depression by 17β-estradiol (E2) was normal mice 1 week after ovariectomy (OVXST), but it impaired 3 months (OVXLT). High-throughput sequencing revealed a decrease miR-221-5p,...
Hormone replacement therapy (HRT) is not recommended for treating learning and memory decline in menopausal women because it exerts adverse effects by activating classic estrogen receptors ERα ERβ. The membrane receptor G protein-coupled 30 (GPR30) has been reported to be involved modulation; however, the underlying mechanisms are poorly understood. Here, we found that GPR30 deletion astrocytes, but neurons, impaired female mice. Astrocytic depletion induced A1 phenotype transition,...
ABSTRACT Long‐term inflammation can cause chronic pain and trigger patients' anxiety by sensitizing the central nervous system. However, effective drugs with few side effects for treating pain‐induced are still lacking. The anxiolytic anti‐inflammatory of ruscogenin (RUS), an important active compound in Ophiopogon japonicus , were evaluated a mouse model inflammatory N9 cells. RUS (5, 10, or 20 mg/kg/day, i.g.) was administered once daily 7 days after CFA injection; pain‐ anxiety‐like...
Background: Cervical cancer is the fourth most common among women worldwide. The zinc finger transcription factor 281 (ZNF281)/ZBP-99 protein specifically binds to GC-rich DNA sequences and regulates gene expression, it has been shown promote tumor progression. In this study, we aim investigate function molecular mechanism of ZNF281 in uterine cervical carcinoma. Methods: We conducted immunohistochemistry Western blot assays determine expression eight human tissues. And, xenograft...
This study aimed to investigate the expression and function of BKCa channels in Sphincter Oddi (SO) a rabbit model hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into 2 groups: control group was fed standard chow (n = 18) whereas high-cholesterol cholesterol-enriched containing 1.5% cholesterol 18). The serum level significantly greater HC groups than group, but there no significant difference body weight between groups. Although total protein α- β1-subunit not...
To investigate the predict value of interleukin-18 (IL-18) combine with kidney injury molecule-1 (KIM-1) on 28-day mortality in patients acute (AKI) undergoing continuous renal replacement therapy (CRRT) intensive care unit (ICU), and to look for start time CRRT.A prospective observational study was conducted. The consecutive AKI critical who underwent CRRT from June 2017 February 2018 admitted ICU Fourth Hospital Hebei Medical University were enrolled. Patients divided into 2 stage 3 groups...