A5100356332- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Temporomandibular Joint Disorders
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Tracheal and airway disorders
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Intestinal Malrotation and Obstruction Disorders
- Metastasis and carcinoma case studies
- Vascular Anomalies and Treatments
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Mental Health Treatment and Access
- Berberine and alkaloids research
- Cardiovascular Health and Disease Prevention
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- COVID-19 and Mental Health
Hangzhou First People's Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Nanjing Agricultural University
2023-2025
Westlake University
2025
Peking University
2007-2024
Second Affiliated Hospital of Zhejiang University
2024
Renji Hospital
2009-2023
Shanghai Jiao Tong University
2009-2023
State Key Laboratory of Oncogene and Related Genes
2013-2023
Guangdong Medical College
2021-2023
BackgroundRheumatoid arthritis is a chronic autoimmune disorder that affects life expectancy. Accelerated biological ageing thought to be major risk factor for age-related diseases, but its role in rheumatoid remains uncertain. We aimed assess the associations between and of genetic susceptibility disease. also effect on expectancy people with arthritis.MethodsWe calculated chronological age-adjusted age—by both Klemera-Doubal method (KDMAge) phenotypic age (PhenoAge)—as surrogate measure...
// Ya-Nan Yu 1, 2, * , Ta-Chung Hui-Jun Zhao 1 Tian-Tian Sun Hui-Min Chen Hao-Yan Hui-Fang An 3 Yu-Rong Weng Jun 4 Min Li 5 Wen-Xin Qin 6 Xiong Ma Nan Shen 7 Jie Hong Jing-Yuan Fang State Key Laboratory of Oncogenes and Related Genes, Division Gastroenterology Hepatology, Renji Hospital, School Medicine, Shanghai Jiaotong University, Cancer Institute, Institute Digestive Disease, Shanghai, China 2 Department Gastroenterology, the Affiliated Hospital Qingdao Qingdao, Shandong Province,...
In recent years, the application of functional genetic immuno-oncology screens has showcased striking ability to identify potential regulators engaged in tumor-immune interactions. Although these have yielded substantial data, few studies attempted systematically aggregate and analyze them.In this study, a comprehensive data collection tumor immunity-associated was performed. Large-scale genomic sets were exploited conduct integrative analyses.We identified 105 regulator genes that could...
Background Gastric peroral endoscopic pyloromyotomy (G-POEM) and gastric electrical stimulation (GES) have been reported as treatment options for refractory gastroparesis. In this study, we compared the long term clinical outcomes of G-POEM versus GES in such patients. Methods We retrospectively evaluated 111 consecutive patients with gastroparesis between January 2009 August 2018. To overcome selection bias, used propensity score matching (1:1) treatment. The primary outcome was duration...
Background. Cluster of differentiation 86 (CD86), also known as B7-2, is a molecule expressed on antigen-presenting cells that provides the costimulatory signals required for T cell activation and survival. CD86 binds to two ligands surface cells: antigen CD28 cytotoxic lymphocyte-associated protein 4 (CTLA-4). By binding CD28, CD86—together with CD80—promotes participation in presentation process. However, interrelationships among CD86, immunotherapy, immune infiltration acute myeloid...
Myocardial infarction (MI) and subsequent ischaemic cardiomyopathy (ICM) are the primary causes of heart failure. Inter-α trypsin inhibitor heavy chain 5 (ITIH5) is an extracellular matrix (ECM) protein has been identified as a myocardial marker ICM. However, its diagnostic value in patients with ICM function molecular mechanism regulating cardiac repair remodelling after MI remain unknown. Three microarray datasets including 117 152 non-failing (NF) tissue samples were merged analysed....
Heat stress (HS) can inhibit the growth performance of broilers and cause substantial economic losses. Alterations in bile acid (BA) pools have been reported to be correlated with chronic HS, yet specific mechanism whether it is related gut microbiota remains unclear. In this study, 40 Rugao Yellow chickens were randomly selected distributed into two groups (20 each group) when reaching 56-day age: a heat group (HS, 36 ± 1 °C for 8 h per day first 7 days 24 last days) control (CN, within 14...
Annexin A10 (ANXA10) belongs to a family of membrane-bound calcium-dependent phospholipid-binding proteins, but its precise function remains unclear. Further research is required understand role in sessile serrated lesions (SSL) and colorectal cancer (CRC). We conducted transcriptome sequencing on pairs SSL corresponding normal control (NC) samples. Bioinformatic methods were utilized assess ANXA10 expression CRC. knocked down overexpressed CRC cells examine effects cell malignant ability....
Interferons‐α/β, which are produced upon viral infection, key soluble factors for the establishment of an antiviral state, but also at low levels in absence infection. Herein, we demonstrate that a weak signal by these constitutively IFN‐α/β show preventive role cellular transformation. Ifnar1 ‐deficient ( −/– ) MEF, devoid signal, undergo spontaneous transformation during long‐term cell culture. Similar to Irf1 primary MEF become tumorigenic nude mice expression activated c‐Ha‐Ras...
Abstract DNA methyltransferase inhibitors (MTIs) have recently emerged as promising chemotherapeutic or preventive agents for cancer, despite their poorly characterized mechanisms of action. The present study shows that methylation is integral to the regulation SH2‐containing protein tyrosine phosphatase 1 (SHP1) expression, but not suppressors cytokine signalling (SOCS)1 SOCS3 in colorectal cancer (CRC) cells. SHP1 expression correlates with down‐regulation Janus kinase/signal transducers...
Abstract Colorectal adenoma (CRA) is the precursor lesion of colorectal cancer (CRC). Several agents have been shown to be effective in chemoprevention CRA recurrence, but there has little research on its primary prevention. Participants older than 50 years with no adenomas were recruited for our study and randomized receive either 1 mg/day folic acid supplement or treatment without acid. After 3 follow-up, plasma folate colonoscopy evaluated. Seven hundred ninety-one participants (91.98%)...
According to the WHO, compared before COVID-19 pandemic, young people showed a significant increase in depressive symptoms. In light of recent coronavirus pneumonia this study was conducted determine how social support, coping style, parent-child relationships, and depression are associated. We investigated these factors interacted affected prevalence during challenging unheard-of time. Our research may help both individuals healthcare professionals better comprehend assist those who with...
IL-6 is reported to be the main upstream activator, instead of downstream target JAK2/STAT3. This study intended explore correlation and JAK2/STAT3 signaling pathway with clinicopathological features prognosis in nasopharyngeal carcinoma (NPC). First, NPC tissues normal epithelial were obtained from 117 patients. Next, we detected expression levels serum those STAT3, p-STAT3, JAK2, p-JAK2 CyclinD1 tissues. A follow-up was conducted all patients survival analyzed. To verify pathway, CNE-1...
The phenylpyrazole insecticide fipronil blocks resistance to dieldrin (RDL) γ-aminobutyric acid (GABA) receptors in insects, thereby impairing inhibitory neurotransmission. Some insect species, such as the diamondback moth (Plutella xylostella), possess more than one Rdl gene. involvement of multiple Rdls toxicity and remains largely unknown. In this study, we investigated roles two genes, PxRdl1 PxRdl2, P. xylostella action. Xenopus oocytes, PxRDL2 were 40 times less sensitive PxRDL1. also...
PTPRZ1–MET (ZM) proteins are a group of fusion identified in human gliomas by high‐throughput transcriptome sequencing. ZM fusions associated with poor prognosis afflicted glioma patients and mediate oncogenic effects assays. In this study, we show that ZM‐carrying have increased hepatocyte growth factor receptor (MET) mRNA expression levels induced receptor‐type tyrosine‐protein phosphatase zeta (PTPRZ1). Furthermore, preserve fundamental properties wild‐type MET respect to processing...