A5101508973- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Berberine and alkaloids research
- Diet and metabolism studies
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Phytochemical Studies and Bioactivities
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Food Quality and Safety Studies
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cancer, Stress, Anesthesia, and Immune Response
- Congenital heart defects research
- Alcohol Consumption and Health Effects
- Pharmacological Effects of Natural Compounds
- Tea Polyphenols and Effects
- Biliary and Gastrointestinal Fistulas
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Gastrointestinal Bleeding Diagnosis and Treatment
Tianjin Medical University General Hospital
2013-2025
Zhongda Hospital Southeast University
2025
Tianjin Medical University
2012-2024
Tianjin International Joint Academy of Biomedicine
2020
Vanderbilt University Medical Center
2015-2017
Institute of Molecular Biology and Biophysics
2013
Jiangsu Province Hospital
2009
Nanjing Medical University
2009
The gut microbiota plays an important role in maintaining intestinal homeostasis. Dysbiosis is associated with tumorigenesis. Deoxycholic acid (DCA), a secondary bile increased by western diet, correlates carcinogenesis. However, evidence relating acids, and tumorigenesis are limited. In our study, we investigated the effect of DCA on induction dysbiosis its roles Alteration composition was induced DCA-treated APCmin/+ mice, which accompanied impaired barrier, low grade inflammation tumor...
High-fat diet (HFD) has long been recognized as risk factors for the development and progression of ulcerative colitis (UC), but exact mechanism remained elusive. Here, HFD increased intestinal deoxycholic acid (DCA) levels, DCA further exacerbated colonic inflammation. Transcriptome analysis revealed that triggered ferroptosis pathway in mice. Mechanistically, upregulated hypoxia-inducible factor-2α (HIF-2α) divalent metal transporter-1 (DMT1) expression, causing ferrous ions accumulation...
Hox gene clusters play an important role during cardiac septation to valve formation in different species, and the miR-196a-HOXB8-Sonic hedgehog signaling pathway is of particular interest. Recently, we found that a genetic variant rs11614913 miR-196a2 sequence could alter mature miR-196a expression target mRNA binding; this observation led us hypothesize might influence susceptibility sporadic congenital heart disease (CHD). We conducted three-stage case-control study CHD Chinese test our...
Abstract High‐fat diet (HFD) is a well‐known risk factor for gut microbiota dysbiosis and colorectal cancer (CRC). However, evidence relating HFD, carcinogenesis limited. Our study aimed to demonstrate that HFD‐induced promoted intestinal adenoma‐adenocarcinoma sequence. In clinical study, we found HFD increased the incidence of advanced neoplasia (AN). The expression monocyte chemoattractant protein 1 (MCP‐1), CC chemokine receptor 2 (CCR2) CD163 in CRC patients with was significantly...
Resident cardiac fibroblasts (CFs) play crucial roles in sensing injury signals and regulating inflammatory responses post-myocardial infarction (MI). Damaged mitochondria can be transferred extracellularly via various mechanisms, including extracellular vesicles (EVs). In this study, we aimed to investigate whether CFs could transfer damaged mitochondrial components small EVs (sEVs) elucidate their role post-MI. Left anterior descending coronary artery ligation was performed mice....
Inflammatory bowel disease (IBD), characterized by sustained inflammation, is a latent risk factor of colon tumorigenesis. Silibinin has been reported to be anti-inflammatory and antineoplastic, but its efficacy on colitis-associated cancer (CAC) not reported. Interlukin-6/signal transducer activator transcription 3 (IL-6/STAT3) the key signaling pathway involved in CAC. We evaluated chemopreventive effect silibinin CAC mouse model determined impact IL-6/STAT3 signaling. Intestinal tumor...
Antitumor effect of berberine has been reported in a wide spectrum cancer, however, the mechanisms which are not fully understood. The aim this study was to investigate hypothesis that suppresses tumorigenesis familial adenomatous polyposis (FAP) by regulating macrophage polarization Apc (min/+) mouse model. Berberine given mice for 12 weeks. Primary macrophages were isolated; after treatment, change signaling cascade determined. total number and size polyps reduced remarkably group,...
Background Gastric polyps, such as adenomas and hyperplastic can be found in various colonic polyposis syndromes. Unlike sporadic gastric adenomas, which the increased risk of colorectal neoplasia has been well characterized, information polyps was limited. Aim To evaluate association with synchronous a large cohort. Methods Patients who underwent colonoscopy simultaneously or within six months were consecutively enrolled. Each patient compared two randomly selected age sex matched controls...
AIMTo analyse the clinical features of patients with serrated lesions in upper gastrointestinal tract (UPGI) tract. METHODSPatients who underwent routine esophagogastroduodenoscopy (EGD) at Digestive Endoscopy Centre General Hospital, Tianjin Medical University between january 2011 and December 2015 were consecutively recruited.Patients UPGI identified.The patients' demographics histopathology recorded.The colorectal findings for colonoscopy simultaneously or within six months also extracted...
Polymorphisms of serotonin transporter (5-HTT) gene were hypothesized to be associated with ventricular septal defects (VSD) related ultrasonographic pulmonary arterial hypertension (PAH) susceptibility. To test this hypothesis, we performed a case-case study in Chinese population and genotyped two polymorphisms (5-HTTLPR 5-HTTVNTR). The LL homozygote 5-HTTLPR 10/10 5-HTTVNTR both significantly increased risk VSD-related PAH. Haplotype analysis showed haplotype L-10 also significant...
A 59-year-old man was hospitalized with acid reflux and diarrhea. Colonoscopy performed while the patient under propofol anesthesia, no abnormalities were observed. However, at 3.5 hours following colonoscopy, had persistent dull pain in lower abdomen.
Alcohol abuse constitutes a significant health hazard, leading to various organ damage, notably the liver and brain. Shanxi aged vinegar (SAV) is one of famous fermented functional foods containing variety bioactive ingredients with beneficial effects on human body. This study aimed explore potential protective effect SAV in alleviating acute alcohol intoxication (AAI) mice. It was found that at 2.5 mg/kg BW effectively ameliorated decline behavioral abilities following consumption,...
Accumulating evidence indicates that the gut microbiota is intricately involved in initiation and progression of human diseases, forming a multidirectional regulatory axis centered on intestinal microbiota. This article illustrates challenges exploring role inflammatory digestive such as metabolic dysfunction-associated steatotic liver disease (MASLD) bowel (IBD), summarizes existing microbiome-focused treatment strategies (probiotics, prebiotics, symbiotics, fecal transplantation,...
Objective To assess the results of colonoscopy surveillance in 5 years after polypectomy non-advanced colorectal adenoma and to identify its risk factors. Methods Patients undergoing followed up with within between January 2003 December 2013 were retrospectively analyzed.No substance or only small quantity clear water left intestinal tract colonoscopes accessing ileocecus regarded as complete examination. The initial was baseline colonoscopy. Patients adenomas assigned case group...
Objective To evaluate the association of gastric hyperplastic polyps with colorectal neoplasia. Methods Data consecutive patients who underwent esophagogastroduodenoscopy(EGD) and colonoscopy between January 2011 December 2013 were reviewed retrospectively. They compared without also EGD in same period. The relationship neoplasia was analyzed. Results The incidence group higher than that control group[24.0%(46/192) VS 10.4%(40/384), P=0.000]. An increased adenomas found, but...