ABSTRACT Scope: Alzheimer's disease (AD) is the most prevalent form of dementia, lack effective therapeutic interventions. In this study, we investigate impact intermittent fasting (IF), an alternative strategy calorie restriction, on cognitive functions and AD‐like pathology in a transgenic mouse model AD. Methods results: APP/PS1 mice at 6 months were randomly allocated to two dietary groups: one receiving ad libitum (AL) feeding other undergoing IF for 1 month. Y maze, Barnes western...

High-fat diet (HFD) intake is commonly related to a substantial risk of cognitive impairment for senior citizens over 65 years age, which constitutes profound global health burden with several economic and social consequences. It critical investigate the effects long-term HFD consumption on function inspect potential underlying mechanisms. In present study, 9-month-old male C57BL/6 mice were randomly assigned either normal (ND, 10 kcal% fat) or an (60 months. Then series behavioral tests,...

Abstract Alzheimer's disease (AD) is the most prevailing form of dementia, with long‐term high‐fat diet (HFD) consumption being a pivotal contributor to AD pathogenesis. As microglial dysfunction crucial factor in onset, it becomes imperative explore effects HFD on function and In present study, 3xTg‐AD model mice at age 9‐month are subjected random allocation, one group receiving standard (ND) other an for 3 months. Subsequently, transcriptomic profiling microglia unveils that alters fatty...

Tangeretin (TAN) exhibits many bioactivities, including neuroprotective effects. However, the efficacy of TAN in Alzheimer's disease (AD) has not been sufficiently investigated. In present study, we integrated behavioral tests, pathology assessment, and biochemical analyses to elucidate antidementia activity APPswe/PSEN1dE9 transgenic (Tg) mice. At supplementation levels 100 mg/kg body weight per day, significantly attenuated cognitive impairment Tg mice tests. These effects were associated...

The insulin-like androgenic gland hormone (IAG) is mainly produced in the (AG) of male crustaceans, and a crucial regulator sexual differentiation. In current study, full-length cDNA IAG swimming crab, Portunus trituberculatus (Pt-IAG), was cloned characterized. Similar to other reported IAGs, deduced amino acid sequence Pt-IAG consist signal peptide, B chain, C peptide A containing 6 conserved cysteines that form two inter-chain disulfide bonds one intra-B chain bond. Tissue distribution...

Alzheimer's disease (AD) is the most common form of dementia in older adults and extracellular accumulation amyloid-β (Aβ) one two characterized pathologies AD. Obesity significantly associated with AD developing factors. Several studies have reported that high fat diet (HFD) influenced Aβ cognitive performance during pathology. However, underlying neurobiological mechanisms not yet been elucidated.The objective this study was to explore HFD pathology.2.5-month-old male APP/PS1 mice were...

Objective Obesity-related diseases such as diabetes, hypertension, dyslipidemia, and cardiovascular have increased due to the obesity epidemic. Early intervention for through lifestyle nutrition plays an important role in preventing obesity-related diseases. Therefore, purpose of this study is explore leucine exercise adiposity, systemic insulin resistance, inflammation provide theoretical guiding basis early prevention treatment obesity. Methods C57BL/6J male mice were randomly divided into...

<b>Objective</b> To analyze the morphological parameters of small intracranial aneurysms using two-dimensional digital subtraction angiography (DSA) and to identify their relationship with rupture risk. <b>Methods</b> Clinical radiologic data from patients DSA-confirmed who received intravascular treatment were retrospectively analyzed. Morphological such as maximum height, transverse diameter, aneurysm neck width, aspect ratio (AR) compared between ruptured unruptured aneurysms. Logistic...

Alzheimer's disease (AD) is the most common neurodegenerative disorder and negative lifestyle factors may contribute to its etiopathogenesis. Substantial evidence from humans murine models reveals that Insulin Resistance (IR) associated with a high fat diet (HFD) increases risk of developing AD age-related amyloidogenesis.The aim study was corroborate clarify influence HFD on amyloidogenesis cognitive deficits in model mice.We here show four months HFD-feeding IR both periphery brain APP/PS1...

Previous studies examining whether autophagy has a protective or deleterious role during ischemia/reperfusion (I/R) injury have reported varying in different organs and remains matter of debate. The aim the current study was to explore hindlimb I/R murine model. An increase apoptosis observed vitro, C2C12 myoblast cells, following hypoxia/reoxygenation (H/R), while downregulation autophagic flux induced by chloroquine as compared with vehicle group under hypoxia H/R conditions. In vivo, an...

Polymorphisms of serotonin transporter (5-HTT) gene were hypothesized to be associated with ventricular septal defects (VSD) related ultrasonographic pulmonary arterial hypertension (PAH) susceptibility. To test this hypothesis, we performed a case-case study in Chinese population and genotyped two polymorphisms (5-HTTLPR 5-HTTVNTR). The LL homozygote 5-HTTLPR 10/10 5-HTTVNTR both significantly increased risk VSD-related PAH. Haplotype analysis showed haplotype L-10 also significant...

It has been determined through extensive studies that autophagy, the Nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome and apoptotic responses in macrophages jointly contribute to atherogenesis its development presence of lipid abnormalities. Few have investigated full-scale if intervention time for lipids abnormality or NLRP3 activation a significant effect on status macrophages.Human THP-1 monocyte-derived were established by challenging...

Background: Alzheimer’s disease (AD), with cognitive impairment as the main clinical manifestation, is a progressive neurodegenerative disease. The assembly of amyloid-β (Aβ) senile plaques one most well-known histopathological alterations in AD. Several studies reported that training reduced Aβ deposition and delayed memory loss. However, long-term benefits spatial underlying neurobiological mechanisms have not yet been elucidated. Objective: To explore effects on AD-related pathogenic...

The hepatopancreas of Procambarus clarkii provides lipids and other nutrients for ovarian development contains hormones such as estradiol related to development. During the P. ovary, hepatopancreas’ tissue structure fatty acid content undergo corresponding changes. A controlled indoor experiment was conducted investigate effects exogenous injection on in clarkii. consists three experimental groups one control group. group were injected with 5, 0.5, 0.05 μg/(g body weight) once every 5 days...

The usage of common alumina supports brings the uncertain and undesirable aluminum transformation into high-silica zeolite membranes thus reduces Si/Al ratio in framework. In this current study, a novel aluminum-free silica carbide (SiC) monolithic support is selected for synthesis SSZ-13 with increased first time. Moreover, high-porosity SiC enables membrane to increase gas permeance surface-to-volume ratio. High-quality were prepared after rational optimization parameters such as...

This trial investigated the effect of dietary Ginkgo biloba leaf (GBL) on growth performance and nonspecific immunity red swamp crayfish Procambarus clarkii. 180 Crayfishes were randomly divided into three groups. One group was fed with basic diet, whereas other two groups diets containing 1% 3% GBL. After 32 days feeding, GBL addition tended to increase body weight gain rate compared control. In group, bodyweight male higher than that female crayfish. While advantageous in terms meat yield....

The present study was conducted to investigate the association between gastric cardiac adenocarcinoma (GCA) and four functional single‑nucleotide polymorphisms (SNPs), including interleukin 18 (IL18) rs360719 A>G, IL18 receptor 1 (IL18R1) rs13015714 G>T, accessory protein (IL18RAP) rs917997 C>T 28B (IL28B) rs8099917 T>G variants. a hospital‑based case‑control performed evaluate genetic effects of these SNPs. A total 243 GCA cases 476 controls were enrolled in this study. custom‑by‑design...

Reverse osmosis (RO) alone has a low water recovery efficiency because of membrane fouling and limited operating pressure. In this study, for the first time, combined reverse osmosis-forward (RO-FO) process was used to improve secondary effluent in printing dyeing wastewater. Effects pressure pH on RO-FO’s removal efficiencies were investigated. Results showed that optimum conditions 1.5 MPa feed solution 9.0. Under optimal conditions, most organic inorganic substances wastewater can be...