A5101525573- Biochemical Analysis and Sensing Techniques
- Autophagy in Disease and Therapy
- Regulation of Appetite and Obesity
- Plant Molecular Biology Research
- Pain Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience and Neuropharmacology Research
- Plant nutrient uptake and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Medicinal Plants and Neuroprotection
- Heme Oxygenase-1 and Carbon Monoxide
- Circadian rhythm and melatonin
- Plant Stress Responses and Tolerance
- Adipokines, Inflammation, and Metabolic Diseases
- melanin and skin pigmentation
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- Memory and Neural Mechanisms
- Vestibular and auditory disorders
- Anesthesia and Neurotoxicity Research
- Seaweed-derived Bioactive Compounds
Qingdao University
2015-2025
Affiliated Hospital of Qingdao University
2015-2025
Peking University
2024
Institute of Molecular Medicine
2024
Center for Life Sciences
2024
Shanghai University of Traditional Chinese Medicine
2018-2023
Shandong University
2016-2023
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023
Guangxi University
2020-2023
Qilu Hospital of Shandong University
2023
Mild hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine, a non-protein amino acid, formed from S-adenosylhomocysteine and partially secreted into plasma. A potential source homocysteine methylation of the lipid phosphatidylethanolamine to phosphatidylcholine by N-methyltransferase in liver. We show that mice lack have plasma levels are approximately 50% those wild-type mice. Hepatocytes isolated methyltransferase-deficient secrete less homocysteine....
MicroRNAs (miRNA/miR) are short non-coding RNAs that function in the endogenous regulation of genes. miRNAs serve important roles cellular events such as apoptosis, cell proliferation, migration, invasion, autophagy and cycle. They also control genesis progression tumors. Autophagy is a self-digestive process occurs response to stress, serves two opposite tumor promotion or inhibition may result resistance therapy. A number studies have revealed autophagic activity by targeting...
High salinity adversely affects crop production. Pyruvic acid is the precursor of abscisic (ABA) and other chemicals that are synthesized in chloroplast, some which involved response to salt. The transportation pyruvic into chloroplast mediated by pyruvate transporters. However, whether transporters salt has not been studied so far. Here, we answered this issue assessing function a wheat transporter response.A TaBASS2 was isolated from salt-tolerant cultivar Shanrong 3. expression induced...
In order to overcome the inflammatory response bacterial infection during wound healing, we have fabricated an antibacterial and anti-inflammatory dressing based on polysaccharide riclin silver nanoparticles (AgNPs).The riclin-AgNPs nanocomposite was developed by borohydride method characterized UV-Vis, TEM, XRD, Zeta potential, DLS. vitro, assessed cumulative release, activities cytotoxicity. vivo, examined healing in mice experiment mediators using histological observations gene expression...
Traditional chemical control methods pose a damaging effect on farmland ecology, and their long-term use has led to the development of pest resistance. Here, we analyzed correlations differences in microbiome present plant soil sugarcane cultivars exhibiting different insect resistance investigate role played by crop We evaluated stems, topsoil, rhizosphere soil, striped borers obtained from infested as well parameters. Results showed that diversity was higher stems insect-resistant plants,...
The mechanism of remimazolam, a benzodiazepine that activates γ-aminobutyric acid (GABAa) receptors, in cerebral ischemia/reperfusion (I/R) injury is not well understood. Therefore, we explored whether remimazolam protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β)/nuclear factor erythroid 2-related 2 (NRF2) to attenuate brain I/R transcerebral I/R-injured rats and transoxygenic glucose deprivation/reperfusion (OGD/R)-injured SY5Y cells. Remimazolam was added at the beginning cell...
Oxidized low-density lipoprotein (ox-LDL) is a major and critical mediator of atherosclerosis, the underlying mechanism thought to involve ox‑LDL‑induced dysfunction endothelial cells (ECs). MicroRNAs (miRNAs), which are group small non‑coding RNA molecules that post‑transcriptionally regulate expression target genes, have been associated with diverse cellular functions pathogenesis various diseases, including atherosclerosis. miRNA-98 (miR‑98) has demonstrated be involved in regulation...
Metabolism serves mammalian feeding and active behavior, is controlled by circadian clock. The molecular mechanism which clock factors regulate metabolic homeostasis under oxidative stress unclear. Here, we have characterized that the daily oxygen consumption rhythm was deregulated in Per1 deficient mice. deficiency impaired mitochondrial dynamics cellular GPx-related ROS fluctuations peripheral organs. We identified PER1 enhanced GPx activity through PER1/GPX1 interaction cytoplasm,...
Autophagy is promoted as a response to such environmental stress conditions ATP depletion and excessive accumulation of reactive oxygen species (ROS). Multiple signalling pathways, including AMP-activated protein kinase (AMPK), are indicated promote autophagy in ischaemic/hypoxic (I/R) heart. However, it's far more clarify the orchestrated cross-talk between AMPK other pathways autophagy. In present study, we investigated induction by hypoxia Rat H9C2 cardiomyocytes with LC3-EGFP reporter,...
Abstract The biological clock is an endogenous timing system, which controls metabolic functions in almost all organs. Nutrient metabolism, substrate processing, and detoxification are circadian controlled livers. However, how the genes respond to toxins influence toxicity keeps unclear. We identified gene Per1 was specifically elevated mice exposed such as carbon tetrachloride (CCl 4 ). Mice lacking slowed down rate of including CCl , capsaicin, acetaminophen, exhibiting relatively more...
Abstract The hormone gibberellin (GA) is crucial for internode elongation in sugarcane. DELLA proteins are critical negative regulators of the GA signaling pathway. ScGAI encodes a protein that was previously implicated regulation sugarcane culm development. Here, we characterized ScGAI-like (ScGAIL) sugarcane, which lacked N-terminal region but otherwise homologous to ScGAI. ScGAIL differed from its chromosomal location, expression patterns, and cellular localization. Although transgenic...
Abstract Genetically modified conditional lethal strains have been created to improve the control of insect pest populations damaging human health and agriculture. However, understanding potential for genetic breakdown lethality systems by rare spontaneous mutations, or selection inherent suppressors, is critical since field release studies are in progress. This knowledge gap was addressed a Drosophila tetracycline-suppressible embryonic system analyzing frequency structure primary-site...
Previous studies have demonstrated that the Wnt/β‑catenin signaling pathway is critical to induction and maintenance of chronic neuropathic pain caused by peripheral inflammation nerve damage. Emerging evidence from recent suggests epigenetic mechanisms may also be pathogenesis pain. The present study aimed elucidate underlying altered Wnt their involvement in CCI‑induced rat sciatic nerves. results a significant increase expression levels Wnt3a dorsal horn rats with CCI. In addition,...
Neuroinflammation is considered as one of the crucial pathogenesis in promoting neurodegenerative progress Alzheimer’s disease (AD). As complementary and alternative therapy, electroacupuncture (EA) stimulation has been widely used clinical practice for anti-inflammation. However, whether EA promotes cognitive deficits resulting from neuroinflammation AD remains unclear. In this study, presenilin 1 2 conditional double knockout (PS cDKO) mice, exhibited a series AD-like pathology, robust...
Epidemiological studies have demonstrated that hypercholesterolemia is associated with an elevated risk of atherosclerosis and cardiovascular diseases. In addition to the available cholesterol-lowering drugs, nutritionally balanced diets containing functional foods attracted much interest as potential candidates improve hypercholesterolemia. study, we dietary succinoglycan riclin effectively alleviated diet-induced Compared high-cholesterol-diet (HCD) group, high-riclin group significantly...