A5052981865- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Acupuncture Treatment Research Studies
- Neuroscience and Neuropharmacology Research
- Advanced Surface Polishing Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Laser Material Processing Techniques
- Pain Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
- Amino Acid Enzymes and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Heat shock proteins research
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Myofascial pain diagnosis and treatment
- Circadian rhythm and melatonin
- Laser-induced spectroscopy and plasma
- Neuroscience of respiration and sleep
- Angiogenesis and VEGF in Cancer
- Metabolism and Genetic Disorders
Shandong University of Traditional Chinese Medicine
2021-2025
China Academy of Engineering Physics
2024-2025
Fujian University of Traditional Chinese Medicine
2024
Guangzhou University of Chinese Medicine
2017-2023
Beijing University of Chinese Medicine
2020-2022
Dalian Medical University
2019
Chongqing Medical University
2018-2019
Second Affiliated Hospital of Chongqing Medical University
2019
Augusta University
2010-2017
Georgia Regents Medical Center
2013-2016
Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due L-arginine depletion. Excessive also can drive metabolism towards the production ornithine, polyamines, proline, promoting proliferation smooth muscle cells collagen formation, leading perivascular fibrosis. We hypothesized that there is specific involvement 1 expression within endothelial this pathology.
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious pathology. Abnormal activation RhoA/Rho kinase (ROCK) pathway has been found to elevate tone through unbalancing production vasodilating vasoconstricting substances. Inhibition RhoA/ROCK can prevent endothelial variety pathological conditions. This review, based on recent molecular, cellular, animal studies, focuses current understanding ROCK its roles dysfunction.
Rationale: Disruption of the circadian clock in mice produces vascular dysfunction as evidenced by impairments endothelium-dependent signaling, vasomotion, and blood vessel remodeling. Although altered function endothelial NO synthase overproduction reactive oxygen species are central to endothelium, date, impact on coupling production is not known. Objective: The goals present study were determine whether deletion a critical component clock, Bmal1, can influence levels arteries from...
We determined the role of Rho kinase (ROCK) isoforms in diabetes-induced vascular endothelial dysfunction and enhancement arginase activity expression. Studies were performed aortic tissues from haplo-insufficient (H-I) ROCK1 ROCK2 mice wild-type (WT) rendered diabetic with streptozotocin bovine cells (BAECs) treated high glucose (HG, 25 mM). Protein expression both ROCK was substantially elevated aortas WT after 8 weeks diabetes BAECs 48 h HG. Impairment endothelium-dependent vasorelaxation...
The suprachiasmatic nucleus of the brain is circadian center, relaying rhythmic environmental and behavioral information to peripheral tissues control physiology. As such, central clock dysfunction can alter systemic homeostasis consequently impair physiology in a manner that secondary malfunction. To determine impact function organ transplantation dissect influence intrinsic tissue clocks versus extrinsic clocks, we implemented blood vessel grafting approach surgically assemble chimeric...
Maternal separation (MS), a stressful event in early life, has been linked to neuropsychiatric disorders later especially depression. In this study we investigated whether treatment with electroacupuncture (EA) could ameliorate depression-related manifestations adult animals that had adverse life experiences. We demonstrated depression-like behavior deficiencies sucrose preference test and forced swimming rat model neonatal maternal separation. Repeated EA at the acupoints Baihui (GV20)...
Early life stress is thought to be a risk factor for emotional disorders, particularly depression and anxiety. Although the excitation/inhibition (E/I) imbalance has been implicated in neuropsychiatric whether early affects E/I balance medial prefrontal cortex at various developmental stages unclear. In this study, rats exposed maternal separation (MS) that exhibited well-established paradigm were used evaluate adolescence (postnatal day P43-60) adulthood (P82-100) by behavior tests,...
Abstract Neuronal nitric oxide synthase (nNOS, gene name Nos1) orchestrates the synthesis of (NO) within neurons, pivotal for diverse neural processes encompassing synaptic transmission, plasticity, neuronal excitability, learning, memory, and neurogenesis. Despite its significance, precise regulation nNOS activity across distinct types remains incompletely understood. Erb-b2 receptor tyrosine kinase 4 (ErbB4), selectively expressed in GABAergic interneurons activated by ligand neuregulin 1...
Dynamic speckle illumination-based quantitative phase microscopy (QPM) offers the capability to eliminate coherent noise and achieve depth selection; however, low coherence of illumination restricts flexibility in objective lens selection. An asymmetric reflective method is proposed this Letter. The field correlation maintained through identical exit pupil diameters objectives both interference arms. Moreover, a light source system with delay line compensates for optical path difference...
Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. This condition increases the of developing coronary, cerebrovascular, peripheral arterial disease fourfold. Endothelial dysfunction contributor to pathogenesis vascular in diabetes patients has recently received increased attention. In this review article, some recent developments that could improve knowledge diabetes-induced endothelial are discussed.
Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide production and impairs endothelial function in vascular pathologies. Using gene deletion model, we investigated involvement of isoforms 1 2 (ARG1 ARG2) hypertension dysfunction mineralocorticoid-salt mouse model. Hypertension was induced wild type (WT), partial ARG1(+/-) knockout (KO), complete ARG2(-/-) KO mice by uninephrectomy deoxycorticosterone acetate (DOCA)-salt treatment for 6-weeks. (Control...
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, associated with endothelial dysfunction. Chronic supplementation l-arginine (l-arg), the substrate for nitric oxide synthase (eNOS), failed to improve vascular function. l-Citrulline (l-cit) not only increases l-arg synthesis, but also inhibits cytosolic arginase I, competitor eNOS use l-arg, in vasculature.To investigate whether l-cit treatment reduces DN streptozotocin (STZ)-induced type 1 diabetes (T1D) mice and rats...
Obesity-induced vascular dysfunction involves pathological remodeling of the visceral adipose tissue (VAT) and increased inflammation. Our previous studies showed that arginase 1 (A1) in endothelial cells (ECs) is critically involved obesity-induced dysfunction. We tested hypothesis EC-A1 activity also drives obesity-related VAT utilized wild-type knockout (KO) mice made obese by high-fat/high-sucrose (HFHS) diet. HFHS diet induced increases body weight, fasting blood glucose, expansion....
Background . Doxorubicin (DOX) is a commonly used chemotherapeutic drug but limited in clinical applications by its cardiotoxicity. Neiguan acupoint (PC6) well‐recognized for the treatment of cardiothoracic disease. However, whether acupuncture at PC6 could be effective preventing DOX‐induced cardiotoxicity still unknown. Methods A set experiments were performed with myocardial cells, wild type, inducible nitric oxide synthase knockout (iNOS‐/‐), and myocardial‐specific ablation arginase 2...
Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular endothelial dysfunction. It can reduce L-arginine availability nitric oxide (NO) synthase (NOS) and NO production. Akita mice, a genetic non-obese type 1 diabetes model, recapitulate human diabetes. We determined the role of Arg time-course diabetes-associated dysfunction aorta corpora cavernosa (CC) from mice.
Background Arterial stiffness (AS) is an independent risk factor for cardiovascular morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen synthesis are key features in development of AS. Arginase (ARG), enzyme implicated many diseases, can compete with nitric oxide (NO) synthase their common substrate, L-arginine. Increased arginase also provide ornithine polyamines via decarboxylase (ODC) proline/collagen aminotransferase (OAT), leading to vascular formation,...
The regulation of epigenetic factors is considered a crucial target for solving complex chronic diseases such as cardio-cerebrovascular diseases. HuangqiGuizhiWuwu Decoction (HGWWD), classic Chinese prescription, mainly used to treat various vascular Although our previous studies reported that HGWWD could effectively prevent dysfunction in diabetic rodent models, the precise mechanism still elusive.In this study, we investigated mechanisms modulating damage endothelial cells diabetes by...