A5091394591- Nanoplatforms for cancer theranostics
- Circadian rhythm and melatonin
- Salivary Gland Disorders and Functions
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Advanced Nanomaterials in Catalysis
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Pain Mechanisms and Treatments
- Cancer-related gene regulation
- Sexual function and dysfunction studies
- Nerve injury and regeneration
- Hydrogen embrittlement and corrosion behaviors in metals
- Welding Techniques and Residual Stresses
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Neurological Disease Mechanisms and Treatments
- Corrosion Behavior and Inhibition
- Coenzyme Q10 studies and effects
- Sleep and Wakefulness Research
- Acupuncture Treatment Research Studies
- Planarian Biology and Electrostimulation
- Rheumatoid Arthritis Research and Therapies
- Biochemical effects in animals
- Oral microbiology and periodontitis research
Zhongnan Hospital of Wuhan University
2018-2025
Wuhan University
2018-2025
Qilu Hospital of Shandong University
2024
Affiliated Hospital of Southwest Medical University
2019-2023
Lanzhou University
2017-2020
Huazhong University of Science and Technology
2010-2020
Lanzhou City University
2019-2020
Wuhan Union Hospital
2011-2020
Wenzhou Medical University
2010-2019
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2014-2019
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by invasive behavior and compromised immune response, presenting treatment challenges. Surgical debulking of GBM fails to address its infiltrative nature, leaving neoplastic satellites in an environment impaired surveillance, ultimately paving the way for recurrence. Tracking eradicating residual cells boosting antitumor immunity critical preventing postoperative relapse, but effective immunotherapeutic strategies...
How to accurately diagnose and treat bacterial infections in vivo remains a huge challenge. Therefore, we have developed targeted delivery nanosystem by coextruding the pretreated macrophage membrane of S. aureus with carbon dots (M@CD). The M@CD demonstrates potent antibacterial effects both vitro through generation reactive oxygen species (ROS). Furthermore, exhibits enhanced targeting ability stable fluorescence properties, addressing issues such as poor efficiency high immunogenicity...
Rationale: Disruption of the circadian clock in mice produces vascular dysfunction as evidenced by impairments endothelium-dependent signaling, vasomotion, and blood vessel remodeling. Although altered function endothelial NO synthase overproduction reactive oxygen species are central to endothelium, date, impact on coupling production is not known. Objective: The goals present study were determine whether deletion a critical component clock, Bmal1, can influence levels arteries from...
The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with β-diketonate two-photon-absorbing (TPA) ligand is rationally designed further functionalized by assembling photosensitizer molecule (methylene blue, MB) in...
The purpose of this study was to determine if consumption appropriate amounts carbohydrate during a period increased exercise training would protect the athletes from becoming over-trained. Eight male competitive cyclists were monitored and tested three periods: a) normal (moderate intensity, long duration, 7 d, NORM); b) overtraining (high intensity training, 15 OVER); c) recovery (minimal 6 REC). Throughout 160 g liquid consumed within first 2 h after daily bout. Mean dietary intake (NORM...
The suprachiasmatic nucleus of the brain is circadian center, relaying rhythmic environmental and behavioral information to peripheral tissues control physiology. As such, central clock dysfunction can alter systemic homeostasis consequently impair physiology in a manner that secondary malfunction. To determine impact function organ transplantation dissect influence intrinsic tissue clocks versus extrinsic clocks, we implemented blood vessel grafting approach surgically assemble chimeric...
P2X is a family of ligand‐gated ion channels that act through adenosine ATP. The 3 receptor plays key role in the transmission neuropathic pain at peripheral and spinal sites. Electroacupuncture (EA) has been used to treat effectively. To determine EA mediated dorsal root ganglion neurons cord, chronic constriction injury (CCI) model was used. Sprague‐Dawley rats were divided into four groups: sham CCI, CCI plus contralateral EA, ipsilateral EA. mechanical withdrawal threshold (MWT) thermal...
Cerium oxide (CeOx) with a reversible surface Ce3+/Ce4+ redox pair has played an important role in catalytic reactions, whereas catalase mimetics of CeOx have attracted little attention the field biotherapy. Herein, smart photosensitizer–cerium nanoprobe was developed to represent promising paradigm high-performance photodynamic therapy. The photosensitizer linked nanoparticles through substrate peptide (EGPLGVRGK) matrix metalloproteinase-2 (MMP-2). could be converted from "silent state"...
Establishing a prognostic risk model based on immunological and disulfidptosis signatures enables precise prognosis prediction of oral squamous cell carcinoma (OSCC). Differentially expressed immune genes were identified in OSCC normal tissues. We examined the model's clinical applicability its relationship to infiltration. Additionally, score, ssGSEA, ESTIMATE, CIBERSORT used evaluate intrinsic molecular subtypes, checkpoints, abundances tumor-infiltrating types proportions between two...
Lysyl oxidase (LOX) is an extracellular enzyme critical for the cross-linking of collagens and elastin. The LOX gene has also been shown to inhibit transforming activity Ras oncogene signaling. Recently, a single-nucleotide polymorphism (SNP) G473A (rs1800449) demonstrated be associated with increased risk breast cancer in African American women. In this hospital-based case–control study, association susceptibility Chinese Han population was investigated. total, 238 female patients 234...
Cardiomyocyte apoptosis is critical for the development of coxsackievirus B3- (CVB3-) induced myocarditis, which a common cardiac disease that may result in heart failure or even sudden death. Previous studies have associated CVB3-induced with downregulation antiapoptotic proteins. Here, attempts were made to examine whether nicotinic acetylcholine receptors (nAChRs), especially α3β4-nAChRs, novel therapeutic target via activation survivin, strong protein, viral myocarditis (VMC). In present...
High fasting plasma glucose (HFPG) is the leading risk factor contributing to increase of stroke burden in past three decades. However, global distribution specifically attributable HFPG was not studied depth. Therefore, we analyzed HFPG-attributable and its subtypes 204 countries territories from 1990 2019.Detailed data on were obtained Global Burden Disease Study 2019. The numbers age-standardized rates disability-adjusted life years (DALYs), deaths, lived with disability, lost between...
Abstract Background Ubiquitination, small ubiquitin‐related modifiers, and NEDDylation are now found to function in cancer biology; however, its role the oral patients remains unclear. Methods A set of bioinformatic tools was integrated analyze expression prognostic significance ubiquitin ubiquitin‐like (UB/UBL) genes. UB/UBL‐related risk score developed via correlation analyses, univariate Cox regression, multivariate regression. Nomogram analysis evaluates model's prediction performance....
To determine whether m6A/m1A/m5C/m7G/m6Am/Ψ-related genes influence the prognosis of a patient with oral squamous cell carcinoma.
Elevated polyamine levels are required for tumor transformation and development; however, expression patterns of polyamines their diagnostic potential have not been investigated in oral squamous cell carcinoma (OSCC), its impact on prognosis has yet to be determined. A total 440 OSCC samples clinical data were obtained from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Consensus clustering was conducted classify patients into two subgroups based the 17 regulators....
(1) Background: The molecular mechanism of oxidative stress-related genes (OSRGs) in myocardial ischemia–reperfusion injury (MIRI) has not been fully elucidated. (2) Methods: Differential expression analysis, enrichment and PPI analysis were performed on the MIRI-related datasets GSE160516 GSE61592 to find key pathways hub genes. OSRGs obtained from Molecular Signatures Database (MSigDB). pattern time changes them studied basis their raw data. Corresponding online databases used predict...
The orphan nuclear receptors retinoic acid-related receptor α and γt (RORα RORγt) are critical in the development of T helper 17 (Th17) cells, ROR-specific synthetic ligands have proven efficacy several mouse models autoimmunity. However, pathological significance RORα primary Sjögren's syndrome (pSS) remains to be elucidated. present study was designed clarify pathogenesis pSS. expression labial salivary gland (LSG) determined by immunohistochemical analysis using a quantitative scoring...
In this work, a smart nanoprobe was designed not only to strengthen cells uptake capacity and modulate tumor hypoxic, but also achieve efficient combination therapy.