A5102010365- Nitric Oxide and Endothelin Effects
- Helicobacter pylori-related gastroenterology studies
- Neuroscience and Neuropharmacology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- Gastric Cancer Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sepsis Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Adipose Tissue and Metabolism
- Digestive system and related health
- Diverse Aspects of Tourism Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hernia repair and management
- Alzheimer's disease research and treatments
- HIV/AIDS drug development and treatment
- Amyotrophic Lateral Sclerosis Research
- Infectious Diseases and Tuberculosis
- Atherosclerosis and Cardiovascular Diseases
- Gut microbiota and health
- Nosocomial Infections in ICU
- Sex work and related issues
- Mycobacterium research and diagnosis
- Syphilis Diagnosis and Treatment
First Hospital of China Medical University
2023-2025
China Medical University
2023-2025
Air Force Medical University
2012-2023
Xijing Hospital
2012-2023
Center for Excellence in Brain Science and Intelligence Technology
2022
Zigong First People's Hospital
2022
Augusta University Health
2018
Augusta University
2017
Gansu Provincial Center for Disease Control and Prevention
2011
Fanjingshan National Nature Reserve
2000
Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due L-arginine depletion. Excessive also can drive metabolism towards the production ornithine, polyamines, proline, promoting proliferation smooth muscle cells collagen formation, leading perivascular fibrosis. We hypothesized that there is specific involvement 1 expression within endothelial this pathology.
Abstract Background Gastric intestinal metaplasia (GIM) represents an important precancerous lesion in intestinal-type gastric cancer, triggered by persistent Helicobacter pylori ( H. ) infection. In a previous study, we unveiled SlyD as novel virulence factor of , establishing its role GIM induction through TPT1. However, the underlying mechanism remains undetermined. Methods epithelial cells were stimulated with 26695, inactivated mutant (ΔSlyD), and purified HpSlyD protein, respectively....
Helicobacter pylori (H. pylori) antibiotic resistance poses a global health threat. Accurate identification of resistant strains is essential for the control infection. In present study, our goal to leverage whole-genome data H. develop practical and interpretable machine learning (ML) models comprehensive assessment. A total 296 isolates with genome-wide were downloaded from Bacterial Viral Bioinformatics Resource Center (BV-BRC) National Biotechnology Information (NCBI) databases. By...
Obesity-induced vascular dysfunction involves pathological remodeling of the visceral adipose tissue (VAT) and increased inflammation. Our previous studies showed that arginase 1 (A1) in endothelial cells (ECs) is critically involved obesity-induced dysfunction. We tested hypothesis EC-A1 activity also drives obesity-related VAT utilized wild-type knockout (KO) mice made obese by high-fat/high-sucrose (HFHS) diet. HFHS diet induced increases body weight, fasting blood glucose, expansion....
THE changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS was assayed by conversion [3H]L-arginine to [3H]L-citrulline, a sensitive fluorometric assay for quantification used. Compared with sham-trained rats, hippocampus cortex, also the cerebellum, elevated significantly one day rats had learnt water-rewarded alteration task. These results suggest memory-related endogenous NO brain, support idea that participates...
Aims To investigate the indicators affecting early outcome of patients with sepsis and to explore its prognostic efficacy for sepsis. Methods We collected clinical data from 201 admitted emergency department Xijing Hospital between June 2019 2022. The were categorized into groups (survival or fatality) based on their 28-day prognosis. characteristics, biochemical indexes, organ function-related indicators, disease scores analyzed both groups. Risk factor analysis was conducted significant...
Gastric cancer is a significant and growing health problem in China. Studies have revealed differences gastric microbiota between patients with non-cancerous patients, suggesting that may play role tumorigenesis. In this meta-analysis, existing 16S rRNA microbial data were analyzed to find combinations consisting of five genera, which had good efficacy distinguishing from multiple types samples. These results lend support the use markers detecting cancer. Moreover, these biomarkers are...
Objective Define the molecular mechanisms underlying obesity‐induced endothelial dysfunction with an emphasis on role of arginase (ARG) as a target for better management disease progression. Introduction Arginase is expressed in cells (EC) 2 isoforms (ARG1 and ARG2) can contribute to vascular by limiting arginine availability nitric oxide (NO) synthesis. Obesity important factor several cardiovascular comorbidities associated dysfunction. characterized adipose tissue dysregulation resulting...
Acute lung injury (ALI) is a clinical syndrome characterized by hyperosmotic pulmonary edema and increased alveolar fluid. Phospholipase C epsilon-1 (PLCE1), identified as member of phospholipase family, the relationship between PLCE1 not clear.To assess possible role Epsilon 1 (PLCE1) in progression related mechanisms.The effects LPS on cell viability apoptosis were examined MTT flow cytometry. Also, level was controlled transfection its plasmid shRNA. The inflammatory response to...
Background: Alzheimer’s disease (AD) is the most seen cause of dementia. Biomarker tests will be essential to improve early diagnosis AD, as treatment more effective in stage. The biomarkers AD are divided into two main classes: amyloid β-peptide (Aβ) accumulation, and tau-related neuronal degeneration. Peripheral blood represents an alternative sample for reflecting pathological events occurring body. Blood samples a possible cerebrovascular fluid samples. potential advantages obvious: less...
BackgroundSevere acute pancreatitis (SAP) is defined as in the context of organ dysfunction, mortality rate which still high.The present study was undertaken to investigate risk factors SAP. MethodsData 312 patients SAP admitted our hospital from January 2010 May 2012 were reviewed.All divided into 2 groups, death group and survival group.The related analyzed with Logistic regression analysis. ResultsSixty-seven (24.48%) died.There significant differences between two groups age, body mass...
Introduction: Obesity is a major contributor to cardiovascular disorders, for which endothelial cell (EC) dysfunction hallmark. Obesity-induced EC has been linked dysregulation of the visceral adipose tissue (VAT) resulting in increased secretion pro-inflammatory cytokine resistin and alterations nitric oxide (NO) producing capacity. However, mechanisms underlying this pathology are not well understood. Hypothesis: Resistin impairs vascular function via upregulation arginase1 (ARG1)...
Purpose We have recently shown that the mitochondrial, ureahydrolase enzyme arginase 2 (A2) mediates retinal neurovascular degeneration after ischemia‐reperfusion (IR) injury by increasing oxidative stress and inflammation. This project aimed to examine role of cytosolic isoform, 1 (A1) in IR injury. specifically focused on endothelial myeloid cells because A1 competes with nitric oxide synthase (NOS) enzymes these for common substrate L‐arginine. L‐arginine depletion reduces NO formation....
Objective To explore the difference of curative effect between traditional surgical treatment and laparoscopic high ligation hernia sac combined with umbilical median repair in children indirect inguinal hernia. Methods A total 100 First Affiliated Hospital People's Liberation Army Air Force Military Medical University were enrolled this study. The clinical data retrospectively analyzed. According to different methods, patients divided into two groups (50 cases each) experiment group...