A5028789700- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Pain Mechanisms and Treatments
- Heat shock proteins research
- Urinary Bladder and Prostate Research
- Neuroendocrine regulation and behavior
- Renin-Angiotensin System Studies
- Advanced Glycation End Products research
- Healthcare and Venom Research
- Eicosanoids and Hypertension Pharmacology
- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Thermoregulation and physiological responses
- Heart Rate Variability and Autonomic Control
- Atherosclerosis and Cardiovascular Diseases
- Diabetes and associated disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuropeptides and Animal Physiology
- Cardiovascular Health and Disease Prevention
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Hypothalamic control of reproductive hormones
- Protein Kinase Regulation and GTPase Signaling
Florida Institute of Technology
2016-2025
Universidade Federal de Minas Gerais
2007-2020
Instituto de Ensino e Pesquisa Santa Casa
2020
Grupo Santa Casa de Belo Horizonte
2020
Augusta University
2008-2017
University of Wisconsin–Madison
2014-2016
Georgia Regents Medical Center
2013-2015
Universidade São Francisco
2015
Augusta University Health
2007-2013
Centro Universitário de Belo Horizonte
2008
Purpose of review Erectile dysfunction is recognized as a quality-of-life disorder that needs to be treated. Currently, it estimated affect many 30 million American men. Thirty percent hypertensive patients complain erectile dysfunction. The understanding common mechanisms involved in the cause associated with hypertension, and investigation antihypertensive drugs impact dysfunction, will provide important tools toward identifying new therapeutic targets improve quality life for these...
A diagnostic of hypertension increases the risk erectile dysfunction (ED); likewise, ED can be an early sign hypertension. In both cases, there is evidence that endothelial a common link between 2 conditions. During hypertension, sustained and widespread release procontractile factors (e.g., angiotensin II, endothelin 1, aldosterone) impairs balance vasoconstrictors vasodilators and, in turn, detrimentally impacts vascular structures. This prohypertensive state associates with enhancement...
Antiretrovirals (ARVs) have become one of the most prescribed groups drugs, and these residues are found in environment. Among them, widely used HIV treatment tenofovir (TDF), lamivudine (3TC), dolutegravir (DTG). This study aimed to evaluate toxicity ARVs TDF, 3TC, DTG on cyanobacterium Microcystis novacekii estimate their environmental risk. showed highest among drugs tested, inhibiting cyanobacteria cell growth metabolic activity at low concentrations. TDF 3TC alone were less toxic, with...
Type 2 diabetes (T2D) is a chronic disease that damages blood vessels and increases the risk of cardiovascular (CVD). Heat-shock protein 70 (HSP70), family chaperone proteins, has been recently reported as key player in vascular reactivity affects large like aorta. Hyperglycemia, hallmark diabetes, correlates with severity damage circulating HSP70 levels. In often show impaired contractility, contributing to dysfunction. However, HSP70’s specific role T2D-related contraction remains unclear....
Diabetic bladder dysfunction (DBD) is a common urological complication of diabetes. Innate immune system activation via Toll-like receptor 4 (TLR4) leads to inflammation and oxidative stress was implicated in diabetes pathophysiology. We hypothesized that hypertrophy hypercontractility DBD mediated by TLR4 activation. Wild-type (WT) knockout (TLR4KO) mice were made diabetic streptozotocin (STZ) treatment, contractile function pathway expression evaluated. Immunohistochemistry confirmed the...
Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide production and impairs endothelial function in vascular pathologies. Using gene deletion model, we investigated involvement of isoforms 1 2 (ARG1 ARG2) hypertension dysfunction mineralocorticoid-salt mouse model. Hypertension was induced wild type (WT), partial ARG1(+/-) knockout (KO), complete ARG2(-/-) KO mice by uninephrectomy deoxycorticosterone acetate (DOCA)-salt treatment for 6-weeks. (Control...
We designed a peptide, PnPP-19, comprising the potential active core of Phoneutria nigriventer native toxin PnTx2-6. investigated its role on erectile function, and toxicity immunogenicity.Erectile function was evaluated by intracavernous pressure-to-mean arterial pressure ratio during electrical field stimulation rat pelvic ganglia. Cavernous strips were contracted with phenylephrine relaxation induced or without PnPP-19 (10(-8) M). Activity sodium channels electrophysiological screening...
Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular endothelial dysfunction. It can reduce L-arginine availability nitric oxide (NO) synthase (NOS) and NO production. Akita mice, a genetic non-obese type 1 diabetes model, recapitulate human diabetes. We determined the role of Arg time-course diabetes-associated dysfunction aorta corpora cavernosa (CC) from mice.
ABSTRACT Infection by nematode parasites with a pulmonary migration in their life cycle and allergic asthma are two highly prevalent diseases humans; therefore, one may expect both occur concomitantly. There is predominant essential role of Th2 lymphocytes the mechanisms underlying control parasite elimination as well pathology observed asthmatic lung. The consequences such situations have been explored, controversial results, justifying development experimental models which relationship...
OPINION article Front. Physiol., 29 May 2019Sec. Vascular Physiology Volume 10 - 2019 | https://doi.org/10.3389/fphys.2019.00655
While precise mechanisms underlying cardiovascular diseases (CVDs) are still not fully understood, previous studies suggest that the innate immune system, through Toll-like receptor 4 (TLR4), plays a crucial part in pathways leading to these diseases, mainly because of its interplay with endogenous molecules. The Heat-shock protein 70 family (HSP70-70kDa) is particular interest tissues as it may have dual effects when interacting TLR4 pathways. Although hypothesis HSP70 members acting...