A5102835393- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Gout, Hyperuricemia, Uric Acid
- Pharmacological Effects of Natural Compounds
- CRISPR and Genetic Engineering
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Renal Diseases and Glomerulopathies
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Berberine and alkaloids research
- Pneumonia and Respiratory Infections
- Hepatocellular Carcinoma Treatment and Prognosis
- Pluripotent Stem Cells Research
- Respiratory viral infections research
- Esophageal Cancer Research and Treatment
- Immune Response and Inflammation
- Drug-Induced Hepatotoxicity and Protection
- Acupuncture Treatment Research Studies
- Ferroptosis and cancer prognosis
Shanghai Tenth People's Hospital
2014-2025
Tongji University
2014-2025
Southern Medical University
2014-2025
Zhengzhou Children's Hospital
2021-2024
Zhengzhou University
2014-2024
Anhui University of Traditional Chinese Medicine
2024
Shanghai Jiao Tong University
2020-2022
Shanghai Children's Hospital
2020-2022
Chinese PLA General Hospital
2022
Weifang Medical University
2021-2022
Dysregulated host-microbial interactions play critical roles in initiation and perpetuation of gut inflammation Crohn's disease (CD). However, the spatial distribution interaction network across intestine its accessory tissues are still elusive. Here, we profile host proteins tissue microbes 540 samples from intestinal mucosa, submucosa-muscularis-serosa, mesenteric adipose tissues, mesentery, lymph nodes 30 CD patients spatially decipher interactions. We observe aberrant antimicrobial...
Combination drugs have been used for several diseases many years since they produce better therapeutic effects. However, it is still a challenge to discover candidates form combination drug. This study aimed investigate whether using comprehensive in silico approach identify novel from Chinese herbal formula an appropriate and creative strategy. We, therefore, Toujie Quwen Granules the main protease (Mpro) of SARS-CoV-2 as example. We first molecular docking components which may inhibit...
Background The etiology of inflammatory bowel disease (IBD) remains unclear. However, intestinal metabolism is known to be critical in the pathogenesis IBD. Bile acid one main metabolites, and its role IBD worthy investigation. This study investigated deoxycholic (DCA), a bile acid, Methods Peripheral serum metabolomics, fecal microbiome analyses were performed on patients with healthy controls. Flow cytometry, real-time quantitative polymerase chain reaction, western blotting, enzyme-linked...
Introduction Hyperuricemia (HUA) is a metabolic disorder caused by purine metabolism dysfunction in which the increasing levels can be partially attributed to seafood consumption. Perillae Folium (PF), widely used plant functional food, has been historically mitigate seafood-induced diseases. However, its efficacy against HUA and underlying mechanism remain unclear. Methods A network pharmacology analysis was performed identify candidate targets potential mechanisms involved PF treating HUA....
A 39-year-old man presented with intermittent vomiting and abdominal pain for 13 years was aggravated by fever, weight loss, diarrhea 2 months. Abdominal computed tomography showed wall thickening of jejunum enlarged retroperitoneal lymph nodes (Figure 1a). Oesophagogastroduodenoscopy revealed rough mucosa in the descending part duodenum 1b). Colonoscopy a patchy erythema (1.2 × 1.5 cm) on sigmoid colon slightly concave surface 1c). Capsule endoscopy significant atrophy small intestinal...
Abstract Mycoplasma pneumoniae necrotizing pneumonia (MPNP) has a long and severe disease course, which seriously threatens to jeopardize patients' lives health. Early prediction is essential for good recovery prognosis. In the present study, we retrospect 128 children with MPNP 118 e combined pulmonary consolidation explore predictive value of lactate dehydrogenase (LDH) in by propensity score matching method, multiple logistic regression analysis, dose–response analysis decision curve...
Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.The study investigated whether azithromycin (AZT) could promote high-fat diet (HFD)-induced Moreover, effect of citrus reticulata pericarpium (CRP) extract on via regulation microbiome exposed antibodies early life were...
The aim of this study was to evaluate the diagnostic performance strain elastography, acoustic radiation force impulse (ARFI) imaging and point shear wave elastography (p-SWE) for assessment predominant types intestinal stenosis in Crohn disease.Twenty-five patients were enrolled study, among whom 25 suspicious stenoses segments studied using gray scale ultrasonography. All 3 methods performed, all underwent endoscopy within 24 hours with pathologic biopsy. sensitivity, specificity,...
Nano-biosynthesis for gold nanoparticle (AuNP) using bacteria can produce the tailored functional AuNP because of different bioactive molecules coating on derived from bacteria. However, biosynthesis biocompatible harmful is still challenging, and extensive application bacteria-derived in tissue repair lacking. In this study, without other auxiliary chemical molecules, gradient centrifugation was used to successfully remove toxic part pristine AuNPs biosynthesized Staphylococcus aureus (S....
Oncostatin M (OSM) is a pleiotropic cytokine of the interleukin-6 family. The role OSM in sepsis remains unknown.Serum level was determined and analyzed septic patients on day intensive care unit (ICU) admission. Furthermore, effects polymicrobial induced by cecal ligation puncture (CLP) were assessed.On ICU admission, had significantly higher serum levels when compared with patient controls healthy volunteers, which related to severity sepsis, including parameters such as sequential...
Abstract Context Qi‐dan‐dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. Objective This study reveals mechanism by which QDD ameliorates DKD. Materials and Methods The compounds in were identified high‐performance liquid chromatography quadrupole‐time‐of‐flight tandem mass spectrometry (HPLC‐Q‐TOF‐MS). Key targets signaling pathways screened through bioinformatics. Nondiabetic Lepr db/m mice as control group,...
The presence of interstitial cells Cajal (ICC) has been described throughout the digestive tract. In this study, we investigated whether ICC also exist in gallbladder wall CD1 mice.Immunofluorescent confocal microscopy was used to identify morphology and distribution either whole-mount flat preparations or enzyme-dispersed from mice. Methylene blue staining transmission electron were performed detect ICC, reverse transcription-polymerase chain reaction (RT-PCR) Western blot confirm...
Abstract Background Paclitaxel induced fatigue still remains underrecognized and undertreated, partly because of limited understanding its pathophysiology lack effective treatments. This study is aim to evaluate the anti-fatigue effects mechanism Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel. Methods Breast established cells randomly repectively divided into five groups: negative control group (NC), tumor (TC), paclitaxel (PTX), (BZYQ) plus (BZYQ + PTX)....
Rationale: Corticosteroid resistance (CR) is a serious drawback to steroid therapy in patients with ulcerative colitis (UC); the underlying mechanism incompletely understood. Twist1 protein (TW1) an apoptosis inhibitor and has immune regulatory functions. This study aims elucidate roles of TW1 inducing sustaining CR status UC. Methods: Surgically removed colon tissues (UC) were collected, from which neutrophils isolated by flow cytometry. The inflammation-related gene activities analyzed RNA...
Sudden cardiac death (SCD) caused by ventricular arrhythmias is the leading cause of mortality cardiovascular disease. Mutation in TECRL, an endoplasmic reticulum protein, was first reported catecholaminergic polymorphic tachycardia during which a patient succumbed to SCD. Using loss- and gain-of-function approaches, we investigated role TECRL murine human cardiomyocytes. Tecrl (knockout, KO) mouse shows significantly aggravated dysfunction, evidenced decrease ejection fraction fractional...
AIM:To detect the vascular endothelial growth factor (VEGF) and soluble splice variant 6 of CD44 (sCD44v6) levels in ascites to explore their role differentiating benign from malignant ascites. METHODS:Cirrhotic (n=36), tuberculosis (n=8) (n=23) were collected studied.Concentrations VEGF sCD44v6 various kinds (n=67) measured using a sandwich enzyme-linked immunoadsorbent assay. RESULTS:VEGF 640.74±264.81pg/ml 89.22±38.20 ng/ml, respectively, both which significantly higher than those...
Objectives: The aim of this study was to develop an ultrasound consolidated score (UCS) in determining the activity Crohn’s disease (CD) and evaluate it with reference simple endoscopic (SES). Methods: From June 2014 2017, 66 patients CD were retrospectively enrolled study. Each patient underwent endoscopy transabdominal (US) examination. morphological symmetry, echogenicity bowel wall, wall layer structure, peri-bowel fat, thickness (BWT), Limberg type on power Doppler US assessed US, UCS...
Lay Summary At present, the conventional therapies for acute severe ulcerative colitis (ASUC) mainly include corticosteroids, cyclosporin, and biological agents. However, treatment of patients with steroid-refractory remains a serious challenge to clinicians. This study reports case ASUC treated cyclosporin combined tofacitinib after failure infliximab.
The incidence of colorectal cancer (CRC) is increasing in young adults, but knowledge regarding the molecular features sporadic early-onset (SEOCRC) limited. objective present study was to investigate potential key tumorigenesis-associated genes and their regulatory microRNAs (miRNAs) SEOCRC. Using miRNA mRNA expression screening SEOCRC late-onset (SLOCRC) by next generation sequencing (NGS) bioinformatics, SEOCRC-associated miRNAome transcriptome were analyzed. In profiles, miRNAs analyzed...